DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and scn2a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_031749252.1 Gene:scn2a / 100486750 XenbaseID:XB-GENE-6447552 Length:1970 Species:Xenopus tropicalis


Alignment Length:1954 Identity:469/1954 - (24%)
Similarity:808/1954 - (41%) Gaps:586/1954 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.|:..||:|...|:|:....|..||:.||..||:.:.:..|         .:..:.|||.|.
 Frog   107 ALYILTPFNPVRQAAIKILVHSLFNMLIMCTILTNCVFMTLSNP---------PEWTKNVEYTFT 162

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.|....:||:.||.|||:::|:..::..:     :..:|.|||.|||||
 Frog   163 GIYTLESLIKILARGFCLEKFTFLRDPWNWLDFSVIVLAYVTEFV-----NLGNVSALRTFRVLR 222

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------- 931
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|...|          
 Frog   223 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKCLLWPYNSSVD 287

  Fly   932 -------RDEITGEYEENIRP--CG----VGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVF 983
                   .:.:..:.|....|  ||    .| :||.||.|......||.|.|:||.|..|.|::|
 Frog   288 ISLYEHFNESLFYKLENQKDPLVCGNSSDTG-KCPEGYVCVKAGRNPNYGYTSFDTFNWAFLSLF 351

  Fly   984 QCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKA------K 1042
            :.:|.:.|.::......|.|..:. ::|:.::.||:|:::||||.|::..: :|:|:|      :
 Frog   352 RLMTQDCWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLVNLILAVVAMAY-EEQNQATIEEAVQ 414

  Fly  1043 NRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLG-EEMPEV 1106
            ...:||:|:::|:                  |..|:...::|..|:   ..:.:|.:| |:..|.
 Frog   415 KEAEFQRLKKQQE------------------EAQALAAAVADVFGE---SQELSEEVGLEDASEC 458

  Fly  1107 QMTESR-----------WRKMKK------------------------------DFDRVNRRM--- 1127
            ..|.|:           |||.:|                              :|.|..||:   
 Frog   459 SSTVSKLSSKSAKERRNWRKQRKQVAHCDGQEKGDKEKCYKSGSEDSIKRKGLNFTREGRRLEEY 523

  Fly  1128 ----------------------------------------------------------------- 1127
                                                                             
 Frog   524 RKSSMPHQSLLSIQGPVFSPRRNSKTSIFSFKDRAKDVGSENDFADDERSTFEEDSRRDPLFVPG 588

  Fly  1128 -RRACRKAVKSQ----------------------------------------------------- 1138
             .||.|.:..||                                                     
 Frog   589 RHRARRNSNISQTSRSSRILPLLSMNGKMHSTVDCNGVVSLVGGSSAPIGLFPEGTTTETDRKRR 653

  Fly  1139 -------------------------------------------AFY--------------WL--- 1143
                                                       .:|              ||   
 Frog   654 PSSYKISMDLMEDPSLRQRAQSIASILTNTMEELQESRRKCPSCWYKFANCFLIWDCCEAWLKVK 718

  Fly  1144 ---------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLG 1193
                           |.:.:.|||..:|.||.....:..:.....|..|.|:||.||:||:.:|.
 Frog   719 RIVKLIVMDPFVDLAITISIVLNTIFMAVEHAHMTPYFISVLTTGNQVFTGIFTAEMVLKLIALD 783

  Fly  1194 FQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASL 1258
            ...||...:|.||..:|..|:.|..|::||     |.||||..|||||||:.|.|.:|:.|:..:
 Frog   784 PYYYFQEGWNIFDGLIVSLSLMELGLSSTG-----GFSVLRSFRLLRVFKLAKSWPTLNKLIKII 843

  Fly  1259 LNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKE---------EKYRMNFDCFWQALLTV 1314
            .||:.::.:|.|:|.:.:.|||::|||:||..:    ||         |..|.:.:.|:.:.|.|
 Frog   844 GNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----KECVCKIAENCELPRWHMNDFFHSFLIV 904

  Fly  1315 FQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAV-----DNLADA 1374
            |:::.|| |...|:..:...|     .::..:.|:::.:.||.::||:|||:.:     |||:..
 Frog   905 FRVLCGE-WIETMWDCMEVAG-----QSMCLLVFMLVMVIGNLVVLNLFLALLLSSFSSDNLSAT 963

  Fly  1375 DSLSEVEKEE--------------------------EPHDESAQKKSHSPTPTIDGMDD-----H 1408
            |..||:...:                          :...:..:.|....||   |.:|     :
 Frog   964 DEDSEINNIQIAVGRIQRGVASGKIILREFFEKLFLQKQKDINETKQLEETP---GKNDTCVLGN 1025

  Fly  1409 LSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVN--TATKILPI 1471
            ..::|..|:.::.|.|.|..|..|  .|.:..|.|:|.            |:.:|  :.|..:||
 Frog  1026 AVVEILKEKNDVRDSDGMTSEIGS--SVEKSAENEKEY------------MTVINKTSLTVAVPI 1076

  Fly  1472 PPGTSFFLFSQTNRF-------------------------------------------------- 1486
            .||.|.|....|..|                                                  
 Frog  1077 APGESDFENPNTEEFSSESDPEETKEKIKVSSSSEGSTIDIRAPGVERIEEFLDYEYEETFDPEP 1141

  Fly  1487 ----------------------------RVFCHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRA 1522
                                        |..|:.:..||.|.:.|:..|:.||..||.|: .:..
 Frog  1142 CFTDDCVASFTCCQINIENGTGRDWWNLRKTCYTIVEHSWFESFIIFMILLSSGALAFEDIYVEQ 1206

  Fly  1523 NDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS- 1585
            ..::..:|...|..|..:|.:|::||.::|||:.: ..|:|     .||.::|.:||:||:::: 
 Frog  1207 RRNVKAILEYADKVFAYIFIMEMLLKWVAYGFIKYFTNAWC-----WLDFIIVDISLVSLIANAL 1266

  Fly  1586 --NAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLF 1648
              :.:..:|.||.||.||||||::|.:|::.||..:|.|:.:|.|::|| ||:.::         
 Frog  1267 GYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLV-CLIFWL--------- 1321

  Fly  1649 KYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC---TDGSKMTQDECYGTYLVYD 1710
                                      :|:::||.||.|||:.|   |.|......:...    |.
 Frog  1322 --------------------------IFSIMGVNLFAGKFYYCVNTTSGVPFPATDVNN----YS 1356

  Fly  1711 DGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIV 1775
            |..::........|.|.:.:||:|..|.|.|..|:||:||..::|.::||.:.|..|.:.....:
 Frog  1357 DCRMYINTTGAARWKNVKVNFDNVGAGYLALLQVATFKGWMPIMYAAVDSREINEQPKYENNTTM 1421

  Fly  1776 AAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALK-------A 1829
            ..|::.:||..:||.:|:|:|.:|..|..:    |.|:....:..|...|    |:|       .
 Frog  1422 YLYFVAFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN----AMKKLGSKKPQ 1482

  Fly  1830 KPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAV 1894
            ||:.|  |.:..|..::.|||..:|:..|.|||.:|.||:.::..:|.......|..:|.:|..:
 Frog  1483 KPIPR--PANCCQGLIFDFVTKQAFDIIIMILIFLNMVTMMIETDDQSQEMEMYLYRINAVFIIL 1545

  Fly  1895 FALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKS 1959
            |..||:.||.:.| :.||...||:||.::|:.|.:.:..:             ||:|     :..
 Frog  1546 FTGEFLLKLISLR-QYYFTIGWNIFDLVVVILSIVGMFLA-------------DIIE-----RYF 1591

  Fly  1960 AGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF 2024
            ....|..:  .||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.||||:.||..|
 Frog  1592 FSPTLFRV--IRLARIGRILRLIKAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1654

  Fly  2025 GKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIM--MSCSAQPDVKCDMNSDTPGE--- 2084
            ..:....|  |....||:||..:::.||:..|...|..::  :..|.:||  ||.|::.||.   
 Frog  1655 AYVKKQSG--IDDMFNFETFGNSMICLFQITTSAGWDLLLEPILNSGEPD--CDPNAEHPGSLFK 1715

  Fly  2085 -PCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSEYDPD 2146
             .||: |:...:|:|:.::...:::|:::|||::||...|.:.: .||....:.|..:|.::||.
 Frog  1716 GDCGNPSVGIFFFVSYIIISFLIVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDPS 1780

  Fly  2147 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSI 2211
            |...|::..:......:.|||...|  |:.:   :|::|::|:.|...:.....|||..:..|. 
 Frog  1781 ASQFIEYSKLSDFADALDPPLRVPK--PNNI---QLIAMDLPMVSGDRIHCLDILFAFTKRVLG- 1839

  Fly  2212 KTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGK---FYATYLIQDYFRRFKK 2273
             ..|.:|    .||..:::.:..:||..:      |......|:.:   ..:..:||..:|||:.
 Frog  1840 -EGGEMD----SLRQPMEERFMTSNPSKV------PYEPITTTLRRKQEEQSAVVIQRCYRRFRL 1893

  Fly  2274 RKEQ 2277
            :|.|
 Frog  1894 KKRQ 1897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 91/303 (30%)
Ion_trans 1137..1379 CDD:395416 87/383 (23%)
Ion_trans 1496..1809 CDD:395416 94/324 (29%)
Ion_trans 1851..2126 CDD:395416 84/281 (30%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 15/74 (20%)
scn2aXP_031749252.1 Ion_trans 127..408 CDD:395416 90/297 (30%)
Na_trans_cytopl 488..678 CDD:403218 9/189 (5%)
Ion_trans 727..940 CDD:395416 71/227 (31%)
Na_trans_assoc 966..1175 CDD:399489 31/225 (14%)
Ion_trans 1179..1454 CDD:395416 93/319 (29%)
Na_channel_gate 1446..1498 CDD:240441 12/57 (21%)
Ion_trans 1503..1758 CDD:395416 84/279 (30%)
GPHH 1770..1817 CDD:407139 13/51 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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