DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1f

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_031747315.1 Gene:cacna1f / 100485906 XenbaseID:XB-GENE-1013840 Length:2034 Species:Xenopus tropicalis


Alignment Length:2156 Identity:1101/2156 - (51%)
Similarity:1363/2156 - (63%) Gaps:344/2156 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   613 EEEEDDTQAFSPFYSSSAELIDNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSGDVSRTAR 677
            |.||:|.....|:.|..||          .|.        ||.|...:              ..|
 Frog     3 EPEENDKGPAPPYSSEEAE----------PFM--------ASAEAALA--------------CWR 35

  Fly   678 YDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQ-----QRRG 737
            |     .:.||..:.|.|         |:|.|              |:..|.:|||     :.:|
 Frog    36 Y-----SMDGGPMMNGTD---------TLNST--------------ASSQAQKKRQYHSKHKNQG 72

  Fly   738 KPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQT 802
            .....|..||||||.:.||:|..||.|||||||:.|||:||||||:||.||.|:|..|||:.|..
 Frog    73 TGGVHRSPRALFCLYLSNPIRRACISIVEWKPFDILILMTIFANCVALGVYIPFPEDDSNIANHN 137

  Fly   803 LEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL---MKDA- 863
            ||:|||:||:|||.|..:||:|||.|||..||:|||||||||.|||||..|..|.|.   ..|| 
 Frog   138 LEQVEYIFLIIFTVESFLKIIAYGLVLHPSAYIRNGWNLLDFVIVVIGLFSVILEQFSHKQGDAH 202

  Fly   864 --------FDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGL 920
                    ||||||||||||||||||||||||.:|||||:||||||.||||||||||||||||||
 Frog   203 HMSGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKAMVPLLHIALLVLFVIIIYAIIGL 267

  Fly   921 ELFSGKLHKAC----RDEITGEYEENIRPC---GVGYQC-PPGYKCYGGWDGPNDGITNFDNFGL 977
            |||.|::||.|    .|.::   ||...||   |.|.:| ....:|.|.|:|||.||||||||..
 Frog   268 ELFIGRMHKTCFYIGSDLVS---EEEPAPCAFSGHGRECLLNNTECRGKWEGPNGGITNFDNFFF 329

  Fly   978 AMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAK 1042
            ||||||||:|:||||||||.:|||||.:..|:||:|:||.|:|||:||:||||||||||||.|||
 Frog   330 AMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 394

  Fly  1043 NRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGK---------GKQPNEMD---- 1094
            .||||||||||||:||||:|||||||||||:|||..   |.|.:         |::...:.    
 Frog   395 ARGDFQKLREKQQMEEDLKGYLDWITQAEDLEPDQE---IRDERHRLSLADITGRRKRRLQWLLH 456

  Fly  1095 -------------------STENLGEE--------MPEVQMTESRWRKMKKDFDRVNRRMRRACR 1132
                               :|||:.||        :.::..| ...||::    |.||..||.||
 Frog   457 ANHSTETHTSLPASETTSVNTENIDEEHANCCARCLSKLSQT-GCCRKIR----RWNRAFRRKCR 516

  Fly  1133 KAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGY 1197
            .||||..|||::::||||||..:|:|||.|.|||...|.|.|...:.|||.||||||||||...|
 Frog   517 LAVKSVTFYWMVLLLVFLNTLTIASEHYQQPDWLTEIQAYANKVLLSLFTLEMLLKMYSLGLHAY 581

  Fly  1198 FVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSI 1262
            |||.|||||||||.|.|.||:|....:|.|||:||||||||||:||||::|.||||||||||||:
 Frog   582 FVSFFNRFDCFVVCGGILETVLVEFDIMSPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSM 646

  Fly  1263 QSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVM 1327
            :|||||||||||||:||:|||||:||||||||..:.| |..||.|.|||||||||:|||||||||
 Frog   647 KSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDTFPQALLTVFQILTGEDWNAVM 710

  Fly  1328 YVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQ 1392
            |.||.||||....|.|.|:|||||||||||||||||||||||||||.|:::  .|:::.:::|.:
 Frog   711 YDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLADGDNIN--SKDKKVNNKSEK 773

  Fly  1393 KKSHSPTPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPR 1457
            |             |..|:.:..|::..:.|          ||..|..||||: ||..:..:...
 Frog   774 K-------------DENSVKVPCEEENENQE----------EEGSEASEEEED-DEGSLPESHLD 814

  Fly  1458 RMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRA 1522
            ::::.....|:||||.|::||:.|.||..||.||.|.:|..|.|:||..|:.||..||||:|:||
 Frog   815 KIADFAPKEKVLPIPEGSAFFILSNTNLLRVGCHKLIHHHIFTNLILVFIILSSISLAAEDPIRA 879

  Fly  1523 NDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNA 1587
            :...|.:|..|||.||::||:|::||:.:||..||.|:|||:.|||||||||.|||||....|:|
 Frog   880 HSFRNHILGYFDYAFTSIFTVEILLKMTAYGAFLHKGSFCRNWFNLLDLLVVSVSLISFGIHSSA 944

  Fly  1588 ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVV 1652
            ||||||||||||||||||||||||||||||||.                                
 Frog   945 ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF-------------------------------- 977

  Fly  1653 KCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKP 1717
                |||:||||||:||.|||||||.||||||||||:.|||.:|.:.:||.||:::|.:|||..|
 Frog   978 ----VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKRSPEECKGTFIIYKEGDVSHP 1038

  Fly  1718 RLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIY 1782
            .:|||.|.|:.|:||:|..||:.|||||||||||.|||.:||:..||.|||:|:|..::.::|:|
 Frog  1039 MVRERIWHNSDFNFDNVLSGMMALFTVSTFEGWPALLYKAIDAYGENVGPIYNYRVEISIFFIVY 1103

  Fly  1783 IIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWW 1847
            ||||||||:||||||||:||:.:||||||||:||||||.|:|:||||:|:|.||||...|||||:
 Frog  1104 IIIIAFFMMNIFVGFVIITFRAQGEQEYKNCELDKNQRQCVEYALKAQPLRLYIPKAKYQYKVWY 1168

  Fly  1848 FVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYF 1912
            .|.|:.|||.:|:||::|||.|||:.|.|...:...:|.|||:||.:|.:|.|.||.|||.|:||
 Frog  1169 MVNSTGFEYIMFVLILLNTVALAMQHYEQSKPFNYAMDILNMVFTGLFTVEMVLKLMAFRPKHYF 1233

  Fly  1913 GDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMR 1977
            .||||.||.:||:||.:||..:|:.:             |....:.|..|:.|||.|||||||||
 Frog  1234 CDAWNTFDALIVVGSLVDIAVTEVNN-------------GWHVGESSEDSSRISITFFRLFRVMR 1285

  Fly  1978 LVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQ 2042
            ||||||||||||||||||||||||||||||||.::||||||:|||.|||||:...:.|..|||||
 Frog  1286 LVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQTFGKIAMQDASQINRNNNFQ 1350

  Fly  2043 TFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSF 2104
            ||.||||:|||.|||||||:||:  ::.|..:||..|| .|||  .|||:.|..|||||::||:|
 Frog  1351 TFPQAVLLLFRCATGEAWQDIML--ASLPGKRCDSESDFGPGEEFTCGSNFAIVYFISFFMLCAF 1413

  Fly  2105 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGF 2169
            ||||||||||||||||||||||||||||||||.|:||||||:|||||||||||||||:|.|||||
 Frog  1414 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGF 1478

  Fly  2170 GKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKR 2234
            |||||||:||||||:||||||:||||.|||||||:|||||.|||:||::.||.||||.||:||||
 Frog  1479 GKLCPHRVACKRLVAMNMPLNADGTVTFNATLFALVRTSLKIKTEGNLETANEELRAVIKKIWKR 1543

  Fly  2235 TNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQE--GKEGHPDSNTVTLQAGLRT 2297
            |..|:||:|:||| .::||||||||||:|||||||:|::|||:.  |.|..| .|:.|||||||:
 Frog  1544 TKQKILDEVIPPP-EEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGTENLP-CNSTTLQAGLRS 1606

  Fly  2298 LHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGAL- 2361
            |.::...::|.||   .||::|.:....|...|..|...|:..  |.|.   .:||.::.:|:: 
 Frog  1607 LQDLGSEIRRVIS---TELEEEEDISGFRALGLQVSEDKSLCE--NLTL---VQATENKISGSVV 1663

  Fly  2362 ----AIGGSASAAL-----------GVGGS--SLVLGSSDPAGGDYLYD----TLNRSVADGVNN 2405
                :|||.....|           .||||  ||::..:.|........    |..|..::| :.
 Frog  1664 SLTNSIGGGREEQLPMSRRSSLINRSVGGSKDSLLVPPTPPPNVSSSMKRRQMTTRRRSSEG-SG 1727

  Fly  2406 ITRNI------------MQARLAAAGKLQ-DELQGAGSGGELRTFGESISMR------PLA---- 2447
            ||..:            :::|..:.|..| :|:|...|..|.:....|...|      |.|    
 Frog  1728 ITPTVHEEEEESAAEHELRSRPPSPGYDQSNEIQRQSSLEESQQRSASPQERVKVLPPPAAPPSS 1792

  Fly  2448 --KNG---GGAATVAGTLPP-----EANAIN-----------------YDN----RNRGIL---- 2477
              .||   |.|......|||     .|.:|.                 :.|    |.||.:    
 Frog  1793 FRANGTLEGRATQRRRLLPPTPGTKSAFSIQCLKRQGSCDDIPIPGTYHQNAPPCRTRGQVYGST 1857

  Fly  2478 ------------LHPYNN-------VYAP------NGALP------GHERMIQSTPASPYDQRRL 2511
                        .|.:.|       :|||      :.|||      .::......|...|.|.|:
 Frog  1858 DSWQRNSYSTNGTHSWANPPKRGRLLYAPLILVEEDSALPTIPCTRWYQEEDSKAPYCHYTQLRV 1922

  Fly  2512 PTS--SDMNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMREALDMTPEEMNLAAHQILSNEH 2573
            |..  ::..|.|:||:..||.:||||.|. |.:||..|.||:.:|..||.:||..||..:||...
 Frog  1923 PGQRLAEKRGSADSLVEAVLISEGLGLYARDPKFVAFAKREIADACQMTIDEMESAASDLLSQSR 1987

  Fly  2574 SLSLIGSSNGS 2584
            ..|..|::..|
 Frog  1988 KGSWTGNNGHS 1998

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 192/294 (65%)
Ion_trans 1137..1379 CDD:395416 172/241 (71%)
Ion_trans 1496..1809 CDD:395416 180/312 (58%)
Ion_trans 1851..2126 CDD:395416 170/277 (61%)
GPHH 2135..2188 CDD:407139 45/52 (87%)
Ca_chan_IQ 2199..2271 CDD:400901 52/71 (73%)
cacna1fXP_031747315.1 Ion_trans 102..394 CDD:395416 192/294 (65%)
Ion_trans 524..756 CDD:395416 168/232 (72%)
Ion_trans 853..1090 CDD:395416 155/272 (57%)
Ion_trans 1175..1435 CDD:395416 169/274 (62%)
GPHH 1444..1497 CDD:407139 45/52 (87%)
Ca_chan_IQ 1508..1579 CDD:400901 52/71 (73%)
CAC1F_C 1602..2031 CDD:407123 102/406 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 377 1.000 Domainoid score I851
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1988 1.000 Inparanoid score I55
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45628
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X533
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.160

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