DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1s

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_031752682.1 Gene:cacna1s / 100485035 XenbaseID:XB-GENE-5823874 Length:1689 Species:Xenopus tropicalis


Alignment Length:1665 Identity:978/1665 - (58%)
Similarity:1221/1665 - (73%) Gaps:121/1665 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   713 PSGAGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLT 777
            |||...::|       .||::::...|...||.|:||||.::||.|..||.||||||||.:||||
 Frog     3 PSGTTMEEG-------TQKKKKKPLVPPSPRPPRSLFCLGLQNPFRKSCINIVEWKPFEMIILLT 60

  Fly   778 IFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLL 842
            |||||||||:|.|.|..|:|..|..|||:||:||.|||.|..:||:||||:||:.|||||.||:|
 Frog    61 IFANCIALAIYLPMPEDDTNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNIL 125

  Fly   843 DFTIVVIGAISTALSQLMK---------DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAM 898
            |||||.:|..:..|.|:.|         ..|:|||||||||||||||||||||||||||||:|||
 Frog   126 DFTIVSVGLFTIVLEQINKVQGVTAPGGTGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAM 190

  Fly   899 VPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYE--ENIRPC---GVGYQCP-PGYK 957
            |||.||||||||:||||||:|.||||||:||.|..:.|....  |...||   |.|.||. .|.:
 Frog   191 VPLLHIALLVLFMIIIYAIVGKELFSGKMHKTCYYKATDVIATVEKPSPCSTTGQGRQCAINGSE 255

  Fly   958 CYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFV 1022
            |.|.|.|||:|||:|||||.|||||:||:|:||||:|||.:.||:|::|.|:||:|:::||:|||
 Frog   256 CRGWWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFV 320

  Fly  1023 MNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKG 1087
            :||:||||||||:|||.|||:||.||||||:|.::|||||||||||.||.::||...|   ||..
 Frog   321 LNLVLGVLSGEFTKEREKAKSRGAFQKLREQQAMDEDLRGYLDWITHAEVMDPDMEQG---DGFS 382

  Fly  1088 KQPNEMDSTENLGEEMPEVQMTES---RWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVF 1149
            :.......||:| .|:..:....|   :||..       :|.:||.||..|||:.|||.:|:::.
 Frog   383 QLEEGCSETESL-YELEGINKFISFLKQWRHW-------HRLLRRKCRDLVKSRFFYWFVILIIL 439

  Fly  1150 LNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1214
            .||..:||||:.|.:||...|:..|...:.:||.||:||:|:||||.||:|||||||||||...|
 Frog   440 FNTITIATEHHNQPEWLTKAQDIANQVLLAMFTLEMVLKIYALGFQSYFMSLFNRFDCFVVCTGI 504

  Fly  1215 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIF 1279
            .|.||.::.:|.|||:|||||:||||:||:|:||.||:|||||||||::||||||||||||::||
 Frog   505 LEILLVSSNIMSPLGISVLRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIF 569

  Fly  1280 ALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALA 1344
            ||||||:|||||:|:..|.: |..||.|.|:|:|||||:||||||:|||.||.||||.:..|...
 Frog   570 ALLGMQMFGGKFDFEDTEIR-RSTFDNFPQSLITVFQILTGEDWNSVMYNGIMAYGGPTFPGMFV 633

  Fly  1345 CIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDDH- 1408
            ||||||||:|||||||||||||||||||:|::|:..:|.:.  :|..:||.....|  |..::. 
 Frog   634 CIYFIILFVCGNYILLNVFLAIAVDNLAEAENLTSAQKAKA--EERKRKKLARAHP--DKSEEEK 694

  Fly  1409 --LSIDIDMEQQ----------ELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSE 1461
              |:..::|:.:          ::|:.:...:|........:...::||.:.|..|:.|||.::|
 Frog   695 LLLAKKLEMKAKGEGIPTTAKLKIDEFESNVNEIKDPYPSADFPGDDEEEEPEIPISPRPRPLAE 759

  Fly  1462 VNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDL 1526
            :....|.:|:|..:|||:|..||:|||.||.:.|.:.|.|.||..|:.||..||||:|:......
 Frog   760 LQLKEKAVPMPDASSFFIFGPTNKFRVLCHRIVNATTFTNFILLFILLSSISLAAEDPIEPESFR 824

  Fly  1527 NKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVV 1591
            |::|..|||.|||:||.|:.||:.:||..||.|:|||:.||:||||||.|||:|....|:|||||
 Frog   825 NQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLVSFGIQSSAISVV 889

  Fly  1592 KILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVV 1656
            ||||||||||||||||||||||||||||.||:||||||||||.||||||:            |  
 Frog   890 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTTLLQFMFS------------C-- 940

  Fly  1657 VAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLRE 1721
                                  ||||||||||:.|||.:|||::||.|.::|..|||..:.:|||
 Frog   941 ----------------------IGVQLFKGKFYSCTDTTKMTEEECRGYFIVAKDGDSTQIQLRE 983

  Fly  1722 REWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIII 1786
            |.|:::.||||:|..||::|||:|||||||.|||.:|||:.|:.|||:|:|..:|.::|||||:|
 Frog   984 RIWTHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILI 1048

  Fly  1787 AFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTS 1851
            ||||:||||||||||||.:||||||||:||||||.|:::||||:|:||||||:..|||:|:.|||
 Frog  1049 AFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRRYIPKNQHQYKIWYLVTS 1113

  Fly  1852 SSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAW 1916
            |.|||.:|.|||:||::|.|:.|.|...::.|.|.||:.||.:|.:|.|.|||||:.|.||||.|
 Frog  1114 SYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFKAKGYFGDPW 1178

  Fly  1917 NVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKL 1981
            |||||:||:||.||::.|||   ||   .|..:..|.:.|.:      |||.|||||||||||||
 Frog  1179 NVFDFLIVIGSIIDVILSEI---DT---PEPVVTPGSEDTSR------ISITFFRLFRVMRLVKL 1231

  Fly  1982 LSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQ 2046
            ||:|||:||||||||||||||||||||||:|||||||:|||||||||:..|..|..|||||||.|
 Frog  1232 LSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMVDGTQINRNNNFQTFPQ 1296

  Fly  2047 AVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSFLIIN 2108
            |||||||.|||||||||:::||.  ...||..|| .|||  .||:|.||.||||||:||:|||||
 Frog  1297 AVLVLFRCATGEAWQEILLACSY--GKLCDPKSDFLPGEEYTCGTSFAYFYFISFYMLCAFLIIN 1359

  Fly  2109 LFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLC 2173
            ||||||||||||||||||||||||||||.|:|:||||:|||||||||||||||:|.|||||||.|
 Frog  1360 LFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFC 1424

  Fly  2174 PHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPK 2238
            |||:||||||||||||||||||.||||||::|||:|.|||:||.:.:|.|||..||:|||||:.|
 Frog  1425 PHRVACKRLVSMNMPLNSDGTVTFNATLFSLVRTALKIKTEGNFEQSNEELRMIIKKIWKRTSMK 1489

  Fly  2239 LLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGH-PDSNTVTLQAGLRTL-HEV 2301
            |||||:||.| |||||||||||.:|||::||:||||  ||...|: |..|.|.:||||||: .||
 Frog  1490 LLDQVIPPIG-DDEVTVGKFYAIFLIQEHFRKFKKR--QEEYYGYRPKKNNVEIQAGLRTVEEEV 1551

  Fly  2302 SPALKRAISGNL---DELDQE------PEPMHRRHHTLFG 2332
            .|.::|||||:|   :||::.      .|.::||...|||
 Frog  1552 EPEMQRAISGDLTAEEELERAMVEAAIEEGIYRRTGGLFG 1591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 185/289 (64%)
Ion_trans 1137..1379 CDD:395416 156/241 (65%)
Ion_trans 1496..1809 CDD:395416 180/312 (58%)
Ion_trans 1851..2126 CDD:395416 182/277 (66%)
GPHH 2135..2188 CDD:407139 44/52 (85%)
Ca_chan_IQ 2199..2271 CDD:400901 49/71 (69%)
cacna1sXP_031752682.1 Ion_trans 50..340 CDD:395416 185/289 (64%)
Ion_trans 427..668 CDD:395416 156/241 (65%)
Ion_trans 794..1071 CDD:395416 180/312 (58%)
Ion_trans 1113..1377 CDD:395416 182/277 (66%)
GPHH 1386..1439 CDD:407139 44/52 (85%)
Ca_chan_IQ 1450..1521 CDD:400901 49/71 (69%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 377 1.000 Domainoid score I851
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1988 1.000 Inparanoid score I55
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 1 1.000 - - otm48359
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 1 1.000 - - X533
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.090

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