DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and scn3a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_012826714.1 Gene:scn3a / 100125099 XenbaseID:XB-GENE-5812330 Length:2019 Species:Xenopus tropicalis


Alignment Length:2037 Identity:490/2037 - (24%)
Similarity:833/2037 - (40%) Gaps:583/2037 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.|:..||||.:.|:|:....|..||:.||..||..:.:..|         .:..:.|||.|.
 Frog   109 ALYILTPFNPLRRISIKILVHSLFSMLIMCTILTNCFFMTMSNP---------PEWTKNVEYTFT 164

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.|.:..:||:.||.|||:::|:..::..:     |..:|.|||.|||||
 Frog   165 GIYTFESLVKILARGFCLESFTFLRDPWNWLDFSVIVMAYVTEFV-----DLGNVSALRTFRVLR 224

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEE 941
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|...| .....|||.
 Frog   225 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKC-VRWPPEYEP 288

  Fly   942 NIRP----------------------------------------CG----VGYQCPPGYKCYGGW 962
            ||..                                        ||    .| |||.||.|....
 Frog   289 NITSYFNETAGLYINVTLNPFNREEYILEETNFYFLPGTRDALLCGNSSDAG-QCPKGYVCLKTG 352

  Fly   963 DGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLIL 1027
            ..||.|.|:||.|..|.|::|:.:|.:.|.::......|.|..:. ::|:.::.||:|:::||||
 Frog   353 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLIL 416

  Fly  1028 GVL-------------------------------------------------------------- 1030
            .|:                                                              
 Frog   417 AVVAMAYEEQNQATLEEAEQKEAEFQLMMEQLKKHQEEIQAAALAAETMDGSREFSGGTGYGGLS 481

  Fly  1031 --SGEFSKERNK-AKNRGDFQKLREKQQIEED--------------------------------- 1059
              |.|.||..:| ||.|.:.:|.|::::..||                                 
 Frog   482 ESSSEASKPSSKSAKERRNRRKKRKQKEQGEDEKADDEKFHKSASETSIKRKGFRFSIEGNRLTY 546

  Fly  1060 -------------LRGYL-----------------------------DWITQAEDIEPDAVGGLI 1082
                         .||.|                             |..:..||.|.......:
 Frog   547 EKKYSSPHQSRLSFRGSLFFPRRDSRASLCSFRGRGKDVGSENDFADDEHSTFEDNESRRGSLFV 611

  Fly  1083 SDGKGKQPN--------------------EMDSTEN-----------------LGEEMPEVQM-- 1108
            ....|::.|                    :|.||.:                 .|..:|||.:  
 Frog   612 PHRHGERRNSNISQTSKASRTLPVLPVNGKMHSTVDCNGVVSLLGGPSGPTSPAGLLLPEVIIDK 676

  Fly  1109 ---------TESRWRK-------MKKDF--DRVNRR------------------MRRAC----RK 1133
                     ||:..||       :..||  |.:.|:                  .|..|    .|
 Frog   677 PASDDNGTNTENELRKRRLSSYHVSMDFLEDPILRQRALSIASNLTNTMEELEESREKCPPCWNK 741

  Fly  1134 AVKSQAFY-----WL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNV 1175
            ...:...:     ||                  |.:.:.|||..:|.|||...|.........|:
 Frog   742 FANTYLIWDCSDSWLKIKHVVNLIVMDPFVDLAITICIVLNTLFMAMEHYPITDEFAGALNVGNL 806

  Fly  1176 FFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLR 1240
            .|.|:||.||:.|:.:|....||...:|.||     |.|....|...|:....|:||||..||||
 Frog   807 VFTGIFTAEMVFKLIALDPYYYFQVGWNIFD-----GVIVSLSLMELGLSDVEGLSVLRSFRLLR 866

  Fly  1241 VFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKE-------- 1297
            |||:.|.|.:|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:    ||        
 Frog   867 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----KECVCKIAPD 927

  Fly  1298 --EKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILL 1360
              |..|.:.:.|:.:.|.||:::.|| |...|:..:...|     .|:....|:::.:.||.::|
 Frog   928 DCELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG-----QAMCLTVFMMVMVIGNLVVL 986

  Fly  1361 NVFLAIAV-----DNLADADSLSEVE-----------------------------------KEEE 1385
            |:|||:.:     ||||..:..:|:.                                   :|.:
 Frog   987 NLFLALLLSSFSSDNLAATEDDNEMNNLQIAVARMHEGIAYVKRKMREFIQNAFVKKQKALEETK 1051

  Fly  1386 PHDESAQKK----SHSPTPTIDGMDDHL----------SIDIDMEQQELDDEDKM---------- 1426
            |.::...:|    |:..|..|....|:|          .|...:|:..:|:.|.|          
 Frog  1052 PLEDMQNQKDSCISNHTTVEISKEYDYLKDGNVTTATSGIGSSVEKYIIDESDYMSFIHNPSLTV 1116

  Fly  1427 ---------DHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIP---------P 1473
                     |.|.|:.||.....:.||..::....::......::..|.:..|:|         |
 Frog  1117 TVPIAVGESDFENLNTEEFSSESDLEESKEKLNSSSSSEGSTVDIRPAGEGEPVPQVEVEEFQEP 1181

  Fly  1474 GTSFF-----------------LFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAEN-PL 1520
            ...|.                 .:.|....|..|..:..|:.|...|:..|:.||..||.|: .:
 Frog  1182 DACFTDGCIRRFPCCVVDVSHGKWKQWWNLRKTCFLIVEHNWFETFIIFMILMSSGALAFEDIYI 1246

  Fly  1521 RANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSS 1584
            .....:..:|...|..||.:|.:|::||.::|||..: ..|:|     .||.|:|.|||:||:::
 Frog  1247 EQRKTIKIILEYADKVFTYIFILEMLLKWVAYGFQKYFTNAWC-----WLDFLIVDVSLVSLIAN 1306

  Fly  1585 S---NAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQ 1646
            :   :.:..:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::       
 Frog  1307 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL------- 1363

  Fly  1647 LFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDD 1711
                                        :|:::||.:|.||:..|.:.:    |:....|.:.::
 Frog  1364 ----------------------------IFSIMGVNMFSGKYGYCVNYT----DDVVFDYTIVNN 1396

  Fly  1712 GDVHKPRLRERE---WSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRP 1773
            .......:.|.:   |.|.:.:||:|..|.|.|..|:||:||..::|.::||.|:...|.:....
 Frog  1397 RSQCMDLISENKTARWKNVKVNFDNVGFGYLALLQVATFKGWMEIMYAAVDSRKQEEQPKYEDNL 1461

  Fly  1774 IVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALK------ 1828
            .:..|::|:||..:||.:|:|:|.:|..|..:    |.|:....:..|...|    |:|      
 Frog  1462 YMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN----AMKKLGSKK 1522

  Fly  1829 -AKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFT 1892
             .|||.|  |.:..|..|:.||:...|:..|.|||.:|.||:.::..:|.:.....|..:|.:|.
 Frog  1523 PQKPVPR--PDNKFQGAVFDFVSKQPFDIAIMILICLNMVTMMIETDDQSIETENNLYWINAVFI 1585

  Fly  1893 AVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTK 1957
            .:|..|.|.||.:.| ..||...||:|||::|:.|.:.:..:             |::|     |
 Frog  1586 VLFTGECVLKLISLR-HYYFTIGWNIFDFVVVILSIVGMFLA-------------DLIE-----K 1631

  Fly  1958 KSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQ 2022
            ......|..:  .||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.||||:.||.
 Frog  1632 YFVSPTLFRV--IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1694

  Fly  2023 VFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSC--SAQPDVKCDMNSDTPGE- 2084
            .|..:..:.|  |....||:||..:::.||:..|...|..::...  |..||  ||..::..|. 
 Frog  1695 NFAYVKKEAG--IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPD--CDPKAEHSGSS 1755

  Fly  2085 ---PCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSEYD 2144
               .||: |:...:|:|:.::...:::|:::|||::||...|.:.: .||....:.|..:|.::|
 Frog  1756 VKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFD 1820

  Fly  2145 PDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSL 2209
            .:|...|:::.:......:.|||...|  |:.   .:|::|::|:.|...:.....|||..:..|
 Frog  1821 SNATQFIQYVKLTDFADALDPPLRMPK--PNN---AQLIAMDLPMVSGDRIHCLDVLFAFTKRVL 1880

  Fly  2210 SIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVT-----VGKFYATYLIQDYFR 2269
            .   :|   |....||..:::.:..:||.        ..:.:.:|     ..:..|..:||..:|
 Frog  1881 G---EG---DEMDNLRQPMEERFMASNPS--------KASYEPITSTLRRKQEELAAIVIQRCYR 1931

  Fly  2270 RFKKRK----------EQEGKEG------------HPDSNTVTLQAGLRTLHEVSPALKRAIS-- 2310
            .:..||          :::||:|            ..:.|:.|.:|.: |....||....:::  
 Frog  1932 CYALRKGIKHASFMYNQEKGKDGGSLLTRKDMLSDRLNGNSTTEKADI-TPSTTSPPSYDSVTKP 1995

  Fly  2311 ----GNLDELDQEPEPMHRRHH 2328
                ...|::::|......|.|
 Frog  1996 DKEKHEKDKIEKEDRGKDVREH 2017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 98/383 (26%)
Ion_trans 1137..1379 CDD:395416 84/279 (30%)
Ion_trans 1496..1809 CDD:395416 93/324 (29%)
Ion_trans 1851..2126 CDD:395416 83/281 (30%)
GPHH 2135..2188 CDD:407139 12/52 (23%)
Ca_chan_IQ 2199..2271 CDD:400901 15/76 (20%)
scn3aXP_012826714.1 Ion_trans 151..430 CDD:278921 86/295 (29%)
Na_trans_cytopl 512..627 CDD:288761 11/114 (10%)
Ion_trans 786..982 CDD:278921 67/210 (32%)
Na_trans_assoc 1008..1216 CDD:284034 28/207 (14%)
Ion_trans 1239..1496 CDD:278921 86/301 (29%)
Na_channel_gate 1488..1540 CDD:240441 14/57 (25%)
Ion_trans 1562..1800 CDD:278921 75/262 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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