DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BicC and YLL032C

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_013068.1	Gene:	YLL032C / 850627	SGDID:	S000003955	Length:	825	Species:	Saccharomyces cerevisiae

Alignment Length:	749	Identity:	141/749 - (18%)
Similarity:	238/749 - (31%)	Gaps:	267/749 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SFNKLMY-PS----AADVAKPPMVGLEVEAGSIGSLSSLHALPSTTSVGSGAPSETQSEISSVDS 65
            :|...:| ||    :.|:...|.:..   :|::.|||.|.......|:...:.|.....::::
Yeast   214 AFKTSIYAPSLITLSRDLKANPQIFF---SGAVHSLSLLARKTLRESISVNSKSFFYRRLTNI-- 273

  Fly    66 DWSDIRAIAMKLGVQNPDDLHTERFKVDRQKLEQLI-KAESSIEGMNGAEYF------------- 116
                           .|..|...| |..:||:.||| |.:|.|...|  ||.
Yeast   274 ---------------TPGKLLFIR-KYYQQKVNQLILKYQSLIRVTN--EYIEFQSISTNLLEMV 320

  Fly   117 --------FHDIMNT---------------TDTYVSWPCRLKIGAKSKKDP--HVRIVGKVDQVQ 156
                    .|:|:..               .|::........:....|:|.  .:.:||......
Yeast   321 IKNFTIQVLHEIVEVQISLNENCAMSPELIIDSFFGHTGNQIVVITPKEDSFNQLIVVGNQSSTD 385

  Fly   157 RAKE-RILSSLDS-------------RGTRVIMKMDVSYTDHSYIIGRGGNNIKRIM-------- 199
            .|.: .||..|..             |..:.|.::...:.|  :|.|:....:.|||
Yeast   386 EASDTSILHYLSDFIMGSNQVINPNLRQIKAIFEIHPDFED--FISGKKNGKLTRIMELSACLIQ 448

  Fly   200 -----DDTHTHIH-----FPDSNRS-------NPTEKSNQV-SLC--------GSL--EGVERAR 236
                 :|.:.:::     |||...|       .|.|:|..: .:|        |||  ..:.:..
Yeast   449 LEMEEEDDNLYLNLVSDSFPDFKESFKNVINEFPAEESFFIPEVCHRPIIGTGGSLIQATMRKHN 513

  Fly   237 ALVRLSTPLLISFEMPVMGPNKPQPDHETPYIKMIETKFNVQVIFSTRPKLHTSLVLVKGSEKES 301
            ..::.|.    ||.:|   .||         |.||...   .||.....|...::.|.|...|:.
Yeast   514 VFIQFSN----SFNLP---QNK---------ISMIRYD---NVIIRCPRKNKANICLAKNDLKQI 559

  Fly   302 AQVRDATQ--LLINFACESIASQILVNVQMEISPQHHEIVKGKNNVNLLSIMERTQTKIIFPDLS 364
            .|..|:.|  .||.|:                |.|:..|:......|::..:|:.:...|...|.
Yeast   560 VQEYDSLQSKTLIRFS----------------SGQYRHILHVNGQKNIIGQIEKNENVYIMIPLK 608

  Fly   365 DMNVKPLK-KSQVTISGRIDDVYLARQQLLGNLPVALIFDFP-DNHNDASEIMSLNTKYGVYITL 427
            :    ||. .||::|.|..::...|..:|: |......::|. |...|.      |.:|..|
Yeast   609 E----PLDGTSQLSIQGNDENASRAANELV-NSAFGYEYEFKIDQEIDP------NKEYEFY--- 659

  Fly   428 RQKQRQSTLAIVVKGVEKFIDKIYEARQEILRLATPFVKPEIPDYYFMPKDKDLNLAYRTQLTAL 492
                   .|.:|     .|:        :|:.:...|.|    |......:||.|....|:...|
Yeast   660 -------NLIVV-----PFL--------QIMNIIVTFEK----DLITFTFEKDTNENTLTKAIEL 700

  Fly   493 LAGYVDSPKT----PSLLPPSLAGQLTPYANNNHLLLNANGLATPTGVCAPTQKYMQLHNSFQQA 553
            |:.|:::.||    ..::...:.|..:..:|.:    |:|
Yeast   701 LSNYLETQKTKIIFKKIIKKFVLGSASSKSNTS----NSN------------------------- 736

  Fly   554 QNRSMVAGGQSNNGNYLQVPGAVAPPLKPPTVSPRNSCSQNTSGYQSFSSSTTSLEQSYPPYAQL 618
                       .|||:.               |..|:.|:.|       ...||...:.|...::
Yeast   737 -----------TNGNFR---------------SMNNAKSRTT-------IDNTSQSGASPQRHKM 768

  Fly   619 PGTVSSTSSSTAGSQNRAHYSPDSTYGSEGGGVG 652
            |     ..::..|:|....|.|::.|...|.|.|
Yeast   769 P-----VITTVGGAQAIKGYIPNTYYNGYGYGYG 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	19/101 (19%)
		vigilin_like_KH	327..393	CDD:239087	14/66 (21%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
YLL032C	NP_013068.1	COG5166	2..704	CDD:227495	115/587 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930