DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and Bicc1

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_113574.1	Gene:	Bicc1 / 83675	MGIID:	1933388	Length:	977	Species:	Mus musculus

Alignment Length:	1037	Identity:	316/1037 - (30%)
Similarity:	470/1037 - (45%)	Gaps:	232/1037 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSLSSLHALPSTTSVGSGAPSETQSEISSVDSD------------WSDIRAIAMKLGVQNPDDLH 86
            |.|::..:.|     ||.:...|.|.::..:.|            ||:
Mouse     8 GYLAAAQSDP-----GSNSERSTDSPVAGSEDDLVAAAPLLHSPEWSE----------------- 50

  Fly    87 TERFKVDRQKLEQLIKAESSIEGMNGAEYFFHDIMNTTDTYVSWPCRLKIGAKSKKDPHVRIVGK 151
             |||:|||:|||.:::|.:..:|.:| |.||..||..|:|.::||.:||||||||||||:::.||
Mouse    51 -ERFRVDRKKLEAMLQAAAEGKGRSG-EDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGK 113

  Fly   152 VDQVQRAKERILSSLDSRGTRVIMKMDVSYTDHSYIIGRGGNNIKRIMDDTHTHIHFPDSNRSNP 216
            .:.|:.|||.|:|.||::..||.:|||||:|:||::||:||||||::|:||..|||||||||:|.
Mouse   114 KEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEDTGCHIHFPDSNRNNQ 178

  Fly   217 TEKSNQVSLCGSLEGVERARALVRLSTPLLISFEMPVMGPNKPQPDHETPYIKMIETKFNVQVIF 281
            .|||||||:.|...|||.|||.:|...||::.||:|:.|..:|.||..||.|:.|...::|.|.|
Mouse   179 AEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGILQPVPDPNTPSIQHISQTYSVSVSF 243

  Fly   282 STRPKLHTSLVLVKGSEKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVKGKNNVN 346
            ..|.:::.:.|.|:||:..:..|::.|.:|:.....|:||.|.|:.|::|:.|||..:.|:|..|
Mouse   244 KQRSRMYGATVTVRGSQNNTNAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSN 308

  Fly   347 LLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDF-PDNHND 410
            :..||:||..:|.|||.|:    |.|||.|.:.|.|:.|.||||.|:|.||:.|:||. .|...|
Mouse   309 VKHIMQRTGAQIHFPDPSN----PQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEDIEVD 369

  Fly   411 ASEIMSLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRL-------ATPFVKPE 468
            ...|..|..:..|:|:::.|.:|.:.:::||.||:....:||||:.:|.|       ||......
Mouse   370 PQVIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLSPAS 434

  Fly   469 IPDYYFMPK-----------------------------DKDLNLAYRTQLTALLAGYVDSPKTPS 504
            .|.....|.                             ...|..|..|.::.|.:....:| :|:
Mouse   435 CPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSATPNSLLNALNTSVSPLQSSSSGTP-SPT 498

  Fly   505 LLPPSLA--GQLTPYANNNHLLLNANGLATPTGVC---APTQKY-----------MQLHNSFQQA 553
            |..|.:|  ...|.::...||:|.:...||.|.:.   .||..:           :.:|.:..|.
Mouse   499 LWAPPIANTASATGFSTIPHLMLPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQT 563

  Fly   554 QNRSMVAGGQSNNGNYLQVPGAVAPPLKPPTV------SPRNSCSQNTSGYQSFSSSTTSLEQSY 612
            :.:::.|   |.|| ::|.......||...::      |.....|..|:|.:..|..:.|:|...
Mouse   564 EGKNISA---SING-HVQPANMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSVEGCN 624

  Fly   613 PPYAQLPGTVSSTSSSTAGSQNRAHYSPDSTYGSEGGGVGGGGGGGARLGRRLSDGVLLGLSNSN 677
            ..:.::....|.:.|..||...:..                 |.......:|.:..:|.|..||:
Mouse   625 DAFVEVGMPRSPSHSGNAGDLKQML-----------------GASKVSCAKRQTVELLQGTKNSH 672

  Fly   678 GGGGNSGGAHLL-----------------PGS--------AESYRSLHYDLGGNKHSGH-RAFDF 716
            ..|.:    .||                 |||        |...:|....|.......| :|||:
Mouse   673 LHGTD----RLLSDPELSATESPLADKKAPGSERAAERAAAAQQKSERARLASQPTYVHMQAFDY 733

  Fly   717 DMKRALGYKAMERTPVAGELRTPTTAWMGMGLSSTSPAPAPLE---------------------- 759
            :.|:.|..|||.:.||..|:||||..|.|:|.|.:.||....|
Mouse   734 EQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTAYEGSSL 798

  Fly   760 -----NGENGAAGGGASSGWRLPPGLGSPYG---LSATTGLLDATPVNRRMQLAKH--------- 807
                 :.....|.|..|..||...|:| |.|   .||..|    :|..::.:..:|
Mouse   799 SLSRSSSREHLASGSESDNWRDRNGIG-PMGHSEFSAPIG----SPKRKQNKSREHYLSSSNYMD 858

  Fly   808 -------------------KDIQTLLTSLGLEHYIKIFVLNEIDLEVFTTLTEENLMELGIAAFG 853
                               .|:..|.:.|||..|..:|...||||:.|.|||:::|.||||..||
Mouse   859 CISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFG 923

  Fly   854 ARKKLLTAIHTLLANEAACSTMPSSSSSQNSSSPRFSGSAAPGAERRP----------SNQW 905
            ||:|:|.||..|..|.......|      |:|...|....|.|  |.|          |.:|
Mouse   924 ARRKMLLAISELSKNRRKLFEPP------NASCTSFLEGGASG--RLPRQYHSDIASVSGRW 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	43/65 (66%)
		vigilin_like_KH	327..393	CDD:239087	29/65 (45%)
		SAM_BICC1	805..868	CDD:188919	30/90 (33%)
		SAM	807..867	CDD:197735	30/87 (34%)
Bicc1	NP_113574.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		8/39 (21%)
		vigilin_like_KH	<80..125	CDD:239087	24/44 (55%)
		vigilin_like_KH	136..202	CDD:239087	43/65 (66%)
		vigilin_like_KH	288..351	CDD:239087	29/66 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..622		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..702		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..848		13/58 (22%)
		SAM_BICC1	875..938	CDD:188919	29/62 (47%)
		SAM	878..935	CDD:197735	28/56 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7119
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1936
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47604
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004093
OrthoInspector	1	1.000	-	-		oto91960
orthoMCL	1	0.900	-	-		OOG6_108156
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3867
SonicParanoid	1	1.000	-	-		X4464
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860