DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BicC and Hdlbp

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_742036.2	Gene:	Hdlbp / 64474	RGDID:	620962	Length:	1268	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	127/582 - (21%)
Similarity:	212/582 - (36%)	Gaps:	160/582 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SFNKLMYPSAADVAKPPMVGLEVEAGSIGSLSSLHALP-----STTSVGSGAPSETQSEISSVDS 65
            |..:::..:...|..||       :.||.....|...|     :.|.|.:.|.|.|.|.:|:  .
  Rat   317 SLQEILERTGVSVEIPP-------SDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVSA--P 372

  Fly    66 DWSDIRAIAMKLG------VQNPDDLHTERFKVDRQKL------EQLIKAESSIEGM-----NGA 113
            .|.. |.|..|.|      .|....:|.| |.....|:      |.:..|:..||||     |..
  Rat   373 SWLH-RFIIGKKGQNLAKITQQMPKVHIE-FTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRM 435

  Fly   114 EYF-------FH---------DIMNTTDTY-VSWPCRLKIGAKSKKDPHVRIVGKVDQVQRAKER 161
            :|.       ||         :|....|.| ||    ::|...|:|...:||.|....||:||..
  Rat   436 DYVEINIDHKFHRHLIGKSGANINRIKDQYKVS----VRIPPDSEKSNLIRIEGDPQGVQQAKRE 496

  Fly   162 IL---SSLDSRGTRVIMKMDVSYTDHSYIIGRGGNNIKRIMDD-THTHIHFPDSNRSNPTEKSNQ 222
            :|   |.:::..|:.::   :....|..|||:.|..|:.|.|. ....|:|||     |.:||..
  Rat   497 LLELASRMENERTKDLI---IEQRFHRTIIGQKGERIREIRDKFPEVIINFPD-----PAQKSEI 553

  Fly   223 VSLCGSLEGVERARALVR------------LSTPLLISFEMPVMGP----------------NKP 259
            |.|.|....||:....::            :|.|:...|...::|.                :.|
  Rat   554 VQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLP 618

  Fly   260 QPDHETPYIKMIETKFN------------------VQVIFSTRPKLHTSLVLVKGS--------- 297
            ..:..:..|.:...:.|                  .:|..|...|||.||:..||.
  Rat   619 AENSNSETIVITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEEC 683

  Fly   298 -------------------EKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVKGKN 343
                               ...|:.|..|.:.|::.|.|.......|:::.:  |::|:.:.||.
  Rat   684 GGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAK--PEYHKFLIGKG 746

  Fly   344 NVNLLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQL------LGNLPVALIF 402
            ...:..:.:.|..:||||...|.:     :..:||.|:.|.|..|:::|      |.|:....:.
  Rat   747 GGKIRKVRDSTGARIIFPAAEDKD-----QDLITIIGKEDAVREAQKELEALIQNLDNVVEDYML 806

  Fly   403 DFPDNHND-----ASEIMSLNTKY-GVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEIL 458
            ..|.:|..     ...:..:..:| ||.::..:...||. .:.:||.:..::...:..|||:
  Rat   807 VDPRHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSD-KVTLKGAKDCVEAAKKRIQEII 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	20/66 (30%)
		vigilin_like_KH	327..393	CDD:239087	17/71 (24%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
Hdlbp	NP_742036.2	vigilin_like_KH	152..213	CDD:239087
		vigilin_like_KH	224..283	CDD:239087
		vigilin_like_KH	297..357	CDD:239087	9/46 (20%)
		vigilin_like_KH	368..425	CDD:239087	13/60 (22%)
		vigilin_like_KH	438..498	CDD:239087	17/63 (27%)
		vigilin_like_KH	509..571	CDD:239087	21/69 (30%)
		vigilin_like_KH	583..644	CDD:239087	7/60 (12%)
		vigilin_like_KH	655..717	CDD:239087	12/61 (20%)
		vigilin_like_KH	729..791	CDD:239087	17/68 (25%)
		vigilin_like_KH	802..864	CDD:239087	9/62 (15%)
		vigilin_like_KH	875..968	CDD:239087
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..946
		vigilin_like_KH	974..1035	CDD:239087
		vigilin_like_KH	1055..1118	CDD:239087
		vigilin_like_KH	1129..1191	CDD:239087
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1214..1268
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740