DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and hdlbpb

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_021335983.1	Gene:	hdlbpb / 555414	ZFINID:	ZDB-GENE-030131-6822	Length:	1259	Species:	Danio rerio

Alignment Length:	824	Identity:	173/824 - (20%)
Similarity:	304/824 - (36%)	Gaps:	216/824 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CASF-NKL---MYPSAADVAKPPMVGLEVEAGSIG-SLSSLHALPSTTSVGSGAPSE-TQSEISS 62
            ||.| .||   :..|:..::.|  :..:.....|| ..:::..:...|:.....|:| :.||:..
Zfish   563 CAKFLQKLIAELVESSFSISVP--IHKQFHKNIIGKGGANIKKIREETNTKIDLPTENSNSEVIV 625

  Fly    63 VDSDWSDIRAIAMKLGVQNPDDLHTERFKVDRQKLEQLI--KAESSIEGMNGAEYFFHDIM-NTT 124
            :....|:..|...::       |..|:.....:::|..|  |..:|:.|..|:  ....|| :..
Zfish   626 ITGKKSNCEAARERI-------LAIEKELASMKEVEVSIPAKLHNSLIGSKGS--LVRSIMEDCG 681

  Fly   125 DTYVSWPCRLKIGAKSKKDPHVRIVGKVDQVQRAKERILSSLDSRGTR---VIMKMDVSYTDHSY 186
            ..::.:|      |:......|.|.|..::|:||::::|...:.:...   |.::....|  |.|
Zfish   682 GVHIHFP------AEGSGLDRVTIRGPAEEVERARKQLLQLAEEKQVNNFSVELQAKPEY--HKY 738

  Fly   187 IIGRGGNNIKRIMDDTHTHIHFPDSNRSNPTEKSNQVSLCGSLEGVERA-RALVRLSTPL--LIS 248
            :|||||.||:|:.|.|...|.||.::    .::...:::.|..|.|..| |.|..|...|  :|.
Zfish   739 LIGRGGANIRRVRDRTGARIIFPSAD----DQEQEHITIMGKEEAVILAQRELETLIKNLDDVIE 799

  Fly   249 FEMPVMGPNKPQPDHETPYI--------KMIETKFNVQVIFSTRPKLHTSLVLVKGSEK--ESAQ 303
            ..|.|      :|.|...::        ::.|....|.|.| .|...|:..:.:||..:  ::|:
Zfish   800 DSMIV------EPRHHRHFVCRRGQVLRELAEEYGGVAVSF-PRTGTHSDSITLKGPRECVDAAK 857

  Fly   304 VRDATQLLINFACESIASQILVNVQMEISPQHHEIVKGKNNVNLLSIMERTQTKIIFPDL----- 363
            .|     :....|: :.||  |::::.|..::|..:.|.....:..|....:.:|.|||.
Zfish   858 KR-----IQEIVCD-LESQ--VSMEVLIPQRYHRAIMGPKGCRIQQITREHEVQIKFPDRDESAA 914

  Fly   364 --------SDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFP-DNH-----NDASEI 414
                    .|.::.|.|...:|::||.:...|||..||..:||.:..:.. |.|     ...|.|
Zfish   915 QEPTSQENGDTDLTPRKCDIITVTGRAEKCELARAALLALVPVTIDVEVSYDLHRYIIGQKGSGI 979

  Fly   415 MSLNTKYGVYITLRQKQRQSTLAIV---VKGVEK----FIDKIYE--ARQEILRLATPFVKPEI- 469
            ..:...|.|.|.:.|.::||.:..:   |..||:    .:|::.|  |.||...|.:..|...:
Zfish   980 RKMMEDYEVNIWVPQPEQQSDIIKITGQVASVERAKHGLLDRVKELQAEQEDRALRSYKVTLSVD 1044

  Fly   470 PDYY------------FMPKDKDLNLAY-----RTQLTALLAGYVDSPKTPSLLPPSLAGQLTPY 517
            |.|:            .:.|:.|:|:.:     ..|...:::||..:..........|...|...
Zfish  1045 PKYHPKIIGRKGAVISQIRKEYDVNVQFPDKGDEQQDVIVISGYERNANDAKSAIEQLVAALQEM 1109

  Fly   518 ANNN-------HL-LLNANGLATPTGVCAPTQKYMQ---LHNSFQQAQNRSMVAGGQSNNGNYLQ 571
            .:.:       |. ::.|.|.|        .:|.|:   :...|.|
Zfish  1110 VSEDVRLDRRVHARIIGARGKA--------IRKIMEEFKVDIRFPQ------------------- 1147

  Fly   572 VPGAVAPPLKPPTVSPRNSCSQNTSGYQSFSSSTTSLEQSYPPYAQLPGTVSSTSSSTAGSQNRA 636
             ||:..|.....|..|.|  ..||..:      ..:||:.|        .:|.|.:.|..:..:
Zfish  1148 -PGSEDPNKVTVTGLPEN--VDNTIDH------LLNLEEEY--------MLSVTETETMAAYMK- 1194

  Fly   637 HYSPDSTYGSEGGGVGGGGGGGARLGRRLSDGVLLGLSNSNGGGGNSGGAHLLPGSAESYRSLHY 701
              .|..|.|:         ||.....|.|:.|.::                         |...:
Zfish  1195 --PPSKTMGT---------GGNDEDNRALAKGFVV-------------------------RDAPW 1223

  Fly   702 DLGGNKHSGHRAFDFDMKRALGYKAMERTPVAGELRTP--TTAW 743
            :..|||             |....:.|..|..|...||  |:||
Zfish  1224 NAQGNK-------------APDVSSAEEFPTFGSGITPKQTSAW 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	22/66 (33%)
		vigilin_like_KH	327..393	CDD:239087	17/78 (22%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
hdlbpb	XP_021335983.1	vigilin_like_KH	149..210	CDD:239087
		vigilin_like_KH	228..282	CDD:239087
		vigilin_like_KH	294..354	CDD:239087
		vigilin_like_KH	365..414	CDD:239087
		vigilin_like_KH	436..495	CDD:239087
		vigilin_like_KH	506..568	CDD:239087	3/4 (75%)
		vigilin_like_KH	580..641	CDD:239087	10/69 (14%)
		vigilin_like_KH	652..714	CDD:239087	16/69 (23%)
		vigilin_like_KH	726..788	CDD:239087	22/67 (33%)
		vigilin_like_KH	799..861	CDD:239087	14/73 (19%)
		vigilin_like_KH	872..945	CDD:239087	14/72 (19%)
		vigilin_like_KH	958..1019	CDD:239087	13/60 (22%)
		vigilin_like_KH	1039..1100	CDD:239087	9/60 (15%)
		vigilin_like_KH	1111..1173	CDD:239087	16/97 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740