DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and anks6

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001005928.1	Gene:	anks6 / 449657	ZFINID:	ZDB-GENE-041010-213	Length:	739	Species:	Danio rerio

Alignment Length:	844	Identity:	186/844 - (22%)
Similarity:	278/844 - (32%)	Gaps:	266/844 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 RGGNNIKRIMDDTHTHI--------HFPDSNRSNPTEKSNQVSLCGSLEGVERARALVRLSTPLL 246
            |||          |||.        .|.|........:.|..:.| |...|:.||||:.:...|.
Zfish    11 RGG----------HTHTVKLLLENGAFVDDCEHACVSEGNTNTHC-SAGSVQEARALLEVRALLA 64

  Fly   247 ISFEMPVMGPNKPQPDHETPYIKMIETKFNVQVIFSTRPKLHT-----SLVLVKGSEKESAQVRD 306
            .:           |.........:::...:.:|       .||     :|:|.......|
Zfish    65 AA-----------QHGQGAAVALLLDWGSDARV-------CHTGTGWSALMLAAAGGSLS----- 106

  Fly   307 ATQLLINFACESIASQILVNVQMEISPQ--HHEIVKGKNNVNLLSIMERTQTKIIFPDLSDMNVK 369
            ..|.|:....:...:.:|.|..:|::.|  ..::.|..:|:.  |:..|       ||  |...:
Zfish   107 VCQQLVERGADPDHTNVLGNTALEVALQLRRRDVQKYLDNIT--SVRPR-------PD--DEKKR 160

  Fly   370 PLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFPD---------NHNDASEIM--SLNTKYGV 423
            |             ||:.|.:  |||  ..|:.:..:         |.:.||.:|  :::.:..|
Zfish   161 P-------------DVFHALK--LGN--AQLVKEIVEQDAAQVDVCNADGASPLMMAAVSGQLEV 208

  Fly   424 YITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRLA---------------TPFVKPEIPDYY 473
            ...|.:|:........|.|....:...|...:|:::..               |.|      |..
Zfish   209 VQLLVEKRADVDRQDSVHGWTALMQATYHGNKEVVKFLLSQGADVQLRAKNGYTAF------DLV 267

  Fly   474 FMPKDKDLNLAYRTQLTALLAG---YVDSPK----------------TPSLLPPSLAGQLTPYAN 519
            .:..|.|      |:|..|||.   .||..|                |||  ||.....|..:.|
Zfish   268 MLLNDPD------TELVRLLASVCMLVDKDKSKQRGKSALRRRASAGTPS--PPEDKTGLKSWWN 324

  Fly   520 N----------NHLL---LNANGLAT-PTGVCAPTQKYMQL-HNSFQQAQNRSMVAGGQS----- 564
            .          .|.|   |:.|.||. |.....|....|:. ....:.|...:..||.||
Zfish   325 RMSNRFRRLKLTHTLRHGLSTNRLAPFPDAADVPLDATMRAEEGGAEVASPTAPPAGAQSTACSR 389

  Fly   565 -----------------------NNGNYLQVPG----AVAPPLKPPTV----------SPRNSCS 592
                                   |.....::|.    ||.||..||:.          |.|::.|
Zfish   390 TEDCGLNGTGSGKEDFLITTMLRNGAPLARLPSEQLKAVIPPFLPPSCFEPWSSERCGSLRDARS 454

  Fly   593 QNT----SGYQSFSSSTTSLEQSYPPYAQLPGTVSSTSSSTAGSQNRAHYSPDSTYGSEG-GGVG 652
            .:|    .|..|..|.|.|:.:......:.|......|.|.:||.|.||    |:.||.| |||.
Zfish   455 THTHSQRPGRSSAGSDTASISRVVNRSIKFPSITKGPSPSNSGSYNSAH----SSGGSNGVGGVN 515

  Fly   653 GGGGGGARLGRRLSDGVL----------LGLSNSNGGGGNS-GGAHL-LPGSAESYRSLHYDLGG 705
            .......|.|...:|.||          .||.:|......: ..||. ||.|...     .:|..
Zfish   516 RHSDTHNRSGGSAADSVLSQIAAQRKRAAGLMDSRSPAVETPSPAHTPLPDSRPK-----LELQK 575

  Fly   706 NKHSGHRAFDFDMKRALGYKAMERTPVAGELRTPTTAWMGMGLSSTSPA--PAPLENGENGAAGG 768
            ...||:.:           ::...:|......:||.|      .:.:||  ||....|.:..:.|
Zfish   576 RPQSGNSS-----------RSKSTSPTLTPSPSPTPA------HTPAPAHTPAHRPTGASADSQG 623

  Fly   769 GASSGWRLPPGLGSPYGLSATTGLLDATPVNRRMQLAKHKDIQTLLTSLGLEHYIKIFVLNEIDL 833
            .||:..|.....||..|                 .:....::..:|..|.||.|..||...|:|:
Zfish   624 SASTQQRSRSSGGSSSG-----------------TITDEDELSGILRKLSLEKYQPIFEEQEVDM 671

  Fly   834 EVFTTLTEENLMELGIAAFGARKKLLTAIHTL---------LANEAACSTMPSSSSSQNSSSPR 888
            |.|.|||:.:|.||||...|.|:::|.||..|         :..|...:...|..||  :|:||
Zfish   672 EAFLTLTDGDLQELGIRTDGPRQQILAAISELNAGKGRERQILQETIINFQSSFGSS--ASTPR 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	16/57 (28%)
		vigilin_like_KH	327..393	CDD:239087	13/67 (19%)
		SAM_BICC1	805..868	CDD:188919	25/71 (35%)
		SAM	807..867	CDD:197735	25/68 (37%)
anks6	NP_001005928.1	ANK repeat	1..32	CDD:293786	8/30 (27%)
		ANK 1	1..30		7/28 (25%)
		ANK	2..144	CDD:238125	31/166 (19%)
		Ank_2	6..122	CDD:289560	26/144 (18%)
		ANK repeat	38..89	CDD:293786	11/69 (16%)
		ANK 2	57..86		2/39 (5%)
		ANK	91..247	CDD:238125	35/188 (19%)
		ANK 3	91..120		5/33 (15%)
		ANK repeat	92..122	CDD:293786	5/34 (15%)
		ANK 4	124..156		10/42 (24%)
		ANK 5	158..188		8/46 (17%)
		Ank_2	164..256	CDD:289560	16/95 (17%)
		ANK repeat	192..223	CDD:293786	6/30 (20%)
		ANK 6	192..221		6/28 (21%)
		ANK repeat	226..256	CDD:293786	3/29 (10%)
		ANK 7	226..255		3/28 (11%)
		Ank_2	231..>301	CDD:289560	15/81 (19%)
		ANK 8	259..290		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..320		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..645		55/238 (23%)
		CytochromB561_N	<532..>624	CDD:286826	22/113 (19%)
		SAM_ANKS6	641..705	CDD:188917	25/63 (40%)
		SAM	644..703	CDD:197735	24/58 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010