DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and Anks6

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001015028.2	Gene:	Anks6 / 362515	RGDID:	3334	Length:	885	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	174/844 - (20%)
Similarity:	293/844 - (34%)	Gaps:	252/844 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 IIGRGGN--NIKRIMDDTHTHIHFPDSNRSNPT--EKSNQVSLCGSLEGVERA-RALVRLS---- 242
            :..|||:  .:|.:::...|..|...|..|..:  .:...:.:...:..|:.. .|:|||.
  Rat   141 VASRGGHLGVVKLLLEAGATVDHRNPSGESTASGGSRDELLGITALMAAVQHGHEAVVRLLMEWG 205

  Fly   243 ------------TPLLISF---------EMPVMGPNKPQPDHETPYIKMIE-TKFNVQV------ 279
                        :||:::.         ::...|.|   |||    :.::| |.|.|.:
  Rat   206 ADPNHTARTVGWSPLMLAALLGKLSVVQQLVEKGAN---PDH----LGVLEKTAFEVALDRKHRD 263

  Fly   280 -------IFSTRPKLHTSLVLVKGSEKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHE 337
                   :.:.|||        ...||....:..|.: :.||       |::..:..| .|.|..
  Rat   264 LADYLDPLTTVRPK--------TDEEKRRPDIFHALK-MGNF-------QLVKEIADE-DPNHVN 311

  Fly   338 IVKGKNNVNLLSIMERTQ---TKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVA 399
            :|.|.....|:......|   .:::....:|||      .|.::.|     :.|..|.
  Rat   312 LVNGDGATPLMLAAVTGQLPLVQLLVEKHADMN------KQDSVHG-----WTALMQA------- 358

  Fly   400 LIFDFPDNHNDASEIMSLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRL---- 460
                   .::...||:......|..:|||.|...:...:|:        .:.:...|::||
  Rat   359 -------TYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM--------LLNDPDTELVRLLASV 408

  Fly   461 ---------ATPFVKPEIP--------DYYFMPKDKDLNLAYRTQLTALLAGYVDSPKTPSLLPP 508
                     ..|..:|.:|        ....:|.||....::.::    ::......|....||.
  Rat   409 CMQVNKDRGGRPSHRPPLPHSKARQPWSIPMLPDDKGGLKSWWSR----MSNRFRKLKLMQTLPR 469

  Fly   509 SL-AGQLTPYANNNHLLLNANGLATP---TGVCAPTQKYMQLHNSF----QQAQNRSMVAGGQSN 565
            .| |.|..|:::...|.|::...|.|   |....|.:......:|.    ::.::..::.....|
  Rat   470 GLAANQPLPFSDEPELALDSTMRAPPQDRTNHLGPPEAAHAAKDSGPGNPRREKDDVLLTTMLRN 534

  Fly   566 NGNYLQVPG----AVAPPLKPPTVSPRNSCSQNTSGYQSFSSS---TTSLEQSYPPYAQLPGTVS 623
            ...:.::|.    ||.||..||            |.::.:||.   |....::.|....||...|
  Rat   535 GAPFPRLPSDKLKAVIPPFLPP------------SSFELWSSDRSRTCPNGKADPMKTVLPPRAS 587

  Fly   624 STSSSTAGSQNRAHYSPDSTYGSEGGGVGGGGGGGARLGRRL-------------SDGVLLGLSN 675
                       |||  |....|::|..           ||.:             |.|......:
  Rat   588 -----------RAH--PVGCVGTDGAA-----------GRPVKFPSISRSPTSPASSGNFNHSPH 628

  Fly   676 SNGGGGNSGGAHLLPGSAESYRSLHYDLGGNKHSGHRAFDFDMKRALGYKAMERTPVAG--ELRT 738
            |:||....|....|.|      .||...||:..|           .|...|.:|...||  |.:.
  Rat   629 SSGGASGVGSMSRLGG------ELHNRSGGSVDS-----------VLSQIAAQRKKAAGLCEQKP 676

  Fly   739 PTTAWMGMGLSSTSPAPAPLENGENGAAGGGA---SSGWRLPPGLGSPYGLSATT---------- 790
            |......:| .:|..:|..|.....|:..|.:   ||..:|.||...|.|.|||:
  Rat   677 PCQQSSPVG-PATGSSPPELPASLLGSGSGSSNVTSSSKKLDPGKRPPSGTSATSKSTSPTLTPS 740

  Fly   791 ---------GLLDATPVNRRMQ---------LAKHKDIQTLLTSLGLEHYIKIFVLNEIDLEVFT 837
                     ..:.::..:|:.:         :....::..:|..|.||.|..||...|:|:|.|.
  Rat   741 PSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFL 805

  Fly   838 TLTEENLMELGIAAFGARKKLLTAIHTLLA-----NEAACSTMPSSSSSQNSSSPRFSGSAAPG 896
            |||:.:|.||||...|:|:::|.||..|.|     .:....|:.:..||..||:   |.:.|||
  Rat   806 TLTDGDLQELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFESSA---SNTRAPG 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	10/57 (18%)
		vigilin_like_KH	327..393	CDD:239087	14/68 (21%)
		SAM_BICC1	805..868	CDD:188919	26/67 (39%)
		SAM	807..867	CDD:197735	25/59 (42%)
Anks6	NP_001015028.2	ANK 1	8..37
		Ank_4	9..89	CDD:290365
		ANK repeat	9..66	CDD:293786
		ANK	63..202	CDD:238125	13/60 (22%)
		ANK 2	68..97
		ANK repeat	69..99	CDD:293786
		Ank_2	73..165	CDD:289560	6/23 (26%)
		ANK repeat	101..132	CDD:293786
		ANK 3	101..130
		ANK repeat	134..165	CDD:293786	6/23 (26%)
		ANK 4	134..163		5/21 (24%)
		Ank_2	139..243	CDD:289560	17/104 (16%)
		ANK repeat	167..210	CDD:293786	7/42 (17%)
		ANK 5	181..210		5/28 (18%)
		ANK	182..371	CDD:238125	41/237 (17%)
		ANK repeat	214..244	CDD:293786	5/32 (16%)
		ANK 6	215..244		5/31 (16%)
		ANK 7	282..312		8/38 (21%)
		Ank_2	287..380	CDD:289560	22/126 (17%)
		ANK repeat	316..347	CDD:293786	5/36 (14%)
		ANK 8	316..345		5/34 (15%)
		ANK	344..>422	CDD:238125	17/110 (15%)
		ANK repeat	350..380	CDD:293786	7/48 (15%)
		ANK 9	350..379		6/47 (13%)
		Ank_2	355..>415	CDD:289560	12/81 (15%)
		ANK 10	383..414		4/38 (11%)
		ANK repeat	383..411	CDD:293786	4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..439		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..522		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..775		52/253 (21%)
		SAM_ANKS6	771..835	CDD:188917	25/63 (40%)
		SAM	774..833	CDD:197735	24/58 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..885		6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10599
eggNOG	1	0.900	-	-		E1_KOG4374
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10627
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000