DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and Bicc1

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_038954757.1	Gene:	Bicc1 / 361832	RGDID:	1307459	Length:	980	Species:	Rattus norvegicus

Alignment Length:	1013	Identity:	307/1013 - (30%)
Similarity:	470/1013 - (46%)	Gaps:	221/1013 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSIGSLSSLHALPSTTSVGSGAPSETQSEISSVDSD------------WSDIRAIAMKLGVQNPD 83
            |..|.|::..:.|     ||.:...|.|.::..:.|            ||:
  Rat     5 GEPGYLAAAQSDP-----GSNSERSTDSPVAGSEDDLVAAAPLLHSPEWSE-------------- 50

  Fly    84 DLHTERFKVDRQKLEQLIKAESSIEGMNGAEYFFHDIMNTTDTYVSWPCRLKIGAKSKKDPHVRI 148
                |||:|||:|||.:::|.:..:|.:| |.||..||..|:|.::||.:||||||||||||:::
  Rat    51 ----ERFRVDRKKLEAMLQAAAEGKGRSG-EDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKV 110

  Fly   149 VGKVDQVQRAKERILSSLDSRGTRVIMKMDVSYTDHSYIIGRGGNNIKRIMDDTHTHIHFPDSNR 213
            .||.:.|:.|||.|::.||::..||.:|||||:|:||::||:||||||::|:||..|||||||||
  Rat   111 SGKKEAVKEAKEMIMAVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEDTGCHIHFPDSNR 175

  Fly   214 SNPTEKSNQVSLCGSLEGVERARALVRLSTPLLISFEMPVMGPNKPQPDHETPYIKMIETKFNVQ 278
            :|..|||||||:.|...|||.|||.:|...||::.||:|:.|..:|.||..||.|:.|...::|.
  Rat   176 NNQVEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGILQPVPDPNTPSIQHISQTYSVS 240

  Fly   279 VIFSTRPKLHTSLVLVKGSEKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVKGKN 343
            |.|..|.:::.:.|:|:||:..:..|::.|.:|:.....|:||.|.|:.|::|:.|||..:.|:|
  Rat   241 VSFKQRSRMYGATVIVRGSQNNTNAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRN 305

  Fly   344 NVNLLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFPDNH 408
            ..|:..||:||..:|.|||.|:    |.|||.|.:.|.|:.|.||||.|:|.||:.|:||..::.
  Rat   306 GSNVKHIMQRTGAQIHFPDPSN----PQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEDI 366

  Fly   409 N-DASEIMSLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRL-------ATPFV 465
            : |...|..|..:..|:|:::.|.:|.:.:::||.||:....:||||:.:|.|       ||...
  Rat   367 DVDPQVITQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLS 431

  Fly   466 KPEIPDYYFMPKDKDLNLAYRTQLTAL-LAG----YVDSPKTPSLLPPSLAGQLTPYANNN---- 521
            ....|.....| ..|:..:....||.| |.|    .:::..||:.|..:|...::|..:::
  Rat   432 PASCPAGLACP-SLDILASAGLGLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSSSSGTP 495

  Fly   522 -----------------------HLLLNANGLATPTGVC---APTQKY-----------MQLHNS 549
                                   ||::.:...||.|.:.   .||..:           :.:|.:
  Rat   496 SPTTLWASSIPNTASATGFSTIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHIN 560

  Fly   550 FQQAQNRSMVAGGQSNNGNYLQVPGAVAPPLKPPTV------SPRNSCSQNTSGYQSFSSSTTSL 608
            ..|.:.:::.|   |.|| ::|.|.....||...::      |.....|..|:|.:..|..:.|:
  Rat   561 SMQTEGKNISA---SING-HVQPPNMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSV 621

  Fly   609 EQSYPPYAQL--------------------PGTVSSTSSSTA----GSQNRAHYSPDSTYGSEGG 649
            |.....:.::                    |..||.....|.    |::|...:|.|
  Rat   622 EGCNDAFVEVGMPRSPSHSGNAGDLKQMLGPSKVSCAKRQTVELLQGTKNSHLHSTD-------- 678

  Fly   650 GVGGGGGGGARLGRRLSDGVLLG----LSNSNGGGGNSGGAHLLPGSAESYRSLHYDLGGNKHSG 710
                         |.|||..|..    |::....|..............|.|:   .|.......
  Rat   679 -------------RLLSDTELSATESPLADKKAPGSERAAERAAAAQQNSERA---RLASQPPYV 727

  Fly   711 H-RAFDFDMKRALGYKAMERTPVAGELRTPTTAWMGMGLSSTSPAPAPLE--------------- 759
            | :|||::.|:.|..|||.:.||..|:||||..|.|:|.|.:.||....|
  Rat   728 HMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTT 792

  Fly   760 ------------NGENGAAGGGASSGWRLPPGLGSPYG---LSATTGLLDATPVNRRMQLAKH-- 807
                        :.....|.|..|..||...|:| |.|   .||..|    :|..::.:..:|
  Rat   793 AYEGSSLSLSRSSSREHLASGSESDNWRDRNGIG-PMGHSEFSAPIG----SPKRKQNKSREHYL 852

  Fly   808 --------------------------KDIQTLLTSLGLEHYIKIFVLNEIDLEVFTTLTEENLME 846
                                      .|:..|.:.|||..|..:|...||||:.|.|||:::|.|
  Rat   853 SSSNYMDCISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKE 917

  Fly   847 LGIAAFGARKKLLTAIHTLLANEAACSTMPSSSSSQNS 884
            |||..||||:|:|.||..|..|.......|::.::..|
  Rat   918 LGITTFGARRKMLLAISELSKNRRKLFEPPNTPTTCTS 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	43/65 (66%)
		vigilin_like_KH	327..393	CDD:239087	29/65 (45%)
		SAM_BICC1	805..868	CDD:188919	30/90 (33%)
		SAM	807..867	CDD:197735	30/87 (34%)
Bicc1	XP_038954757.1	KH-I_BICC1_rpt1	48..128	CDD:411848	42/98 (43%)
		KH-I_BICC1_rpt2	133..202	CDD:411849	45/68 (66%)
		KH-I_BICC1_rpt3	286..351	CDD:411850	30/68 (44%)
		SAM_BICC1	876..939	CDD:188919	29/62 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6923
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2076
OMA	1	1.010	-	-		QHG47604
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004093
OrthoInspector	1	1.000	-	-		oto95531
orthoMCL	1	0.900	-	-		OOG6_108156
Panther	1	1.100	-	-	LDO	PTHR10627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4464
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830