Protein Alignment BicC and HDLBP

DIOPT Version :10

• Sequence 1: NP_476865.1
• Gene: BicC / 34946
• FlyBaseID: FBgn0000182
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_005327.1
• Gene: HDLBP / 3069
• HGNCID: 4857
• Length: 1268
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 126/585 - (21%)
• Similarity: 216/585 - (36%)
• Gaps: 166/585 - (28%)

  Fly     6 SFNKLMYPSAADVAKPP------MVGLEVEAGSIG-SLSSLHALPSTTSVGS-GAPSETQSEISS 62
            |..:::..:...|..||      .|.|..|...:| :|:.::|..::.:|.| .|||
Human   317 SLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPS-------- 373

  Fly    63 VDSDWSDIRAIAMKLG------VQNPDDLHTERFKVDRQKL------EQLIKAESSIEGM----- 110
                |.. |.|..|.|      .|....:|.| |.....|:      |.:..|:..||||
Human   374 ----WLH-RFIIGKKGQNLAKITQQMPKVHIE-FTEGEDKITLEGPTEDVNVAQEQIEGMVKDLI 432

  Fly   111 NGAEYF-------FH---------DIMNTTDTY-VSWPCRLKIGAKSKKDPHVRIVGKVDQVQRA 158
            |..:|.       ||         :|....|.| ||    ::|...|:|...:||.|....||:|
Human   433 NRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVS----VRIPPDSEKSNLIRIEGDPQGVQQA 493

  Fly   159 KERIL---SSLDSRGTRVIMKMDVSYTDHSYIIGRGGNNIKRIMDD-THTHIHFPDSNRSNPTEK 219
            |..:|   |.:::..|:.::   :....|..|||:.|..|:.|.|. ....|:|||     |.:|
Human   494 KRELLELASRMENERTKDLI---IEQRFHRTIIGQKGERIREIRDKFPEVIINFPD-----PAQK 550

  Fly   220 SNQVSLCGSLEGVERARALVR------------LSTPLLISFEMPVMGP---------------- 256
            |:.|.|.|....||:....::            :|.|:...|...::|.
Human   551 SDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKI 615

  Fly   257 NKPQPDHETPYIKMIETKFN------------------VQVIFSTRPKLHTSLVLVKGS------ 297
            :.|..:..:..|.:...:.|                  .:|..|...|||.||:..||.
Human   616 DLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIM 680

  Fly   298 ----------------------EKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVK 340
                                  ...|:.|..|.:.|::.|.|.......|:::.:  |::|:.:.
Human   681 EECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAK--PEYHKFLI 743

  Fly   341 GKNNVNLLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQL------LGNLPVA 399
            ||....:..:.:.|..::|||...|.:     :..:||.|:.|.|..|:::|      |.|:...
Human   744 GKGGGKIRKVRDSTGARVIFPAAEDKD-----QDLITIIGKEDAVREAQKELEALIQNLDNVVED 803

  Fly   400 LIFDFPDNHND-----ASEIMSLNTKY-GVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEIL 458
            .:...|.:|..     ...:..:..:| ||.::..:...||. .:.:||.:..::...:..|||:
Human   804 SMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSD-KVTLKGAKDCVEAAKKRIQEII 867

  Fly   459  458
            Human   868  867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	KH-I_BICC1_rpt1	85..166	CDD:411848	31/111 (28%)
		KH-I_BICC1_rpt2	171..240	CDD:411849	21/69 (30%)
		KH-I_BICC1_rpt3	325..393	CDD:411850	17/73 (23%)
		SAM_BICC1	805..868	CDD:188919
HDLBP	NP_005327.1	KH-I_Vigilin_rpt1	77..144	CDD:411833
		KH-I_Vigilin_rpt2	147..221	CDD:411834
		KH-I_Vigilin_rpt3	224..283	CDD:411835
		KH-I_Vigilin_rpt4	297..358	CDD:411836	9/40 (23%)
		KH-I_Vigilin_rpt5	364..433	CDD:411837	21/82 (26%)
		KH-I_Vigilin_rpt6	435..502	CDD:411804	19/70 (27%)
		KH-I_Vigilin_rpt7	507..573	CDD:411838	21/73 (29%)
		KH-I_Vigilin_rpt8	583..644	CDD:411839	7/60 (12%)
		KH-I_Vigilin_rpt9	653..722	CDD:411840	14/68 (21%)
		KH-I_Vigilin_rpt10	726..791	CDD:411841	16/71 (23%)
		KH-I_Vigilin_rpt11	802..867	CDD:411842	11/65 (17%)
		KH-I_Vigilin_rpt12	875..970	CDD:411843
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..944
		KH-I_Vigilin_rpt13	972..1049	CDD:411844
		KH-I_Vigilin_rpt14	1053..1126	CDD:411845
		KH-I_Vigilin_rpt15	1128..1196	CDD:411846
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1233..1268