DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and RGD1561230

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001100438.1	Gene:	RGD1561230 / 302776	RGDID:	1561230	Length:	676	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	106/518 - (20%)
Similarity:	195/518 - (37%)	Gaps:	103/518 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RAIAMKLGVQNPDDLHT-----ERFKVDRQKLEQLIK-----AESSIEGMNGAEYFF---HD--I 120
            |||...|..:| .||.|     |..|..:::|:.|:|     .|.||.......::|   .|  |
  Rat   174 RAIFPTLKNKN-QDLVTIIGKEEAVKEVQKELDLLLKDLEYVVEDSILINRKFHHYFIMRRDQLI 237

  Fly   121 MNTTDTYVSWPCRLKIGAKSKKDPHVRIVGKVDQVQRAKERILSSLDSRGTRVIMKMDVSYTDHS 185
            ...|:.|..  ..:....:.|:...|.:.|:...|:.||:.:....:..|:.|..:..|....::
  Rat   238 REMTEVYAG--MIINFTYEGKQSIRVTMKGEKACVEAAKKHVQQIFEPLGSHVTTQYVVPQKFYT 300

  Fly   186 YIIGRGGNNIKRIMDDTHTHIHFPDSNRS------------------NPTE-------KSNQVSL 225
            :.:|...:.:::|..|....:.|||..::                  |..|       ||..:.:
  Rat   301 FFMGPLCSKVQQIARDFKVQLAFPDKGKTTMYVHPVVQETEKEKWGKNSKELVFSNERKSKTILI 365

  Fly   226 CGSLEGVERARALVRLSTPLLISFEMPVMGPNKPQP---DHETPYIKMIETKFNVQVIFSTRPKL 287
            .|.:|..:.|...:.    .||.|...|..|:...|   .|:...||.|.::|:|....| :|..
  Rat   366 SGQMENCKAAMEALE----YLIPFTAEVQVPSHLHPYIIGHKGSGIKKIMSEFDVHTQVS-QPGG 425

  Fly   288 HTSLVLVKGSEKESAQVRDATQLLINFACESIASQILVNVQM--EISPQHHEIVKGKNNVNLLSI 350
            ::.::.:.|...:..|.:...:..||.....|..:.|.|.::  .:..::|.::.|...:.:..|
  Rat   426 NSDIISIMGLAAKVNQAKIKLEKQINALQTEIEDRALRNFKLMFTLDAKYHSMITGHKGLFIAQI 490

  Fly   351 MERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLAR---QQLLGNLPVALIFDFPDNHNDAS 412
            .......|.||..|:..:    :.|:||:|..::...|:   .::|..:...:..:.|.|.....
  Rat   491 CREHDVNIHFPKKSNREI----QDQITITGYKNNTLAAKDAIMRMLYKIEKTVSKEIPVNPQVRD 551

  Fly   413 EIMSLNTKY------GVYITLRQKQRQS-TLAIVVKGVEKFIDKIYEARQEILRLATPFVKPEIP 470
            .|.....||      .:::.:|...:.| ...|.|.|:.   :|:.||...||         ::.
  Rat   552 SIFGFGGKYIHRLNEQLHVDIRLPPKGSWNTNITVIGLP---EKVQEAIDHIL---------DLE 604

  Fly   471 DYYFMPKDKDLNLAYRTQLTALLAGYVDSPKTPSLL-----PPSLAGQ------LTPYANNNH 522
            .||.     .:.:.|.:||..|        |...|.     ||..:|:      ..|..|:.|
  Rat   605 KYYL-----SVVIKYDSQLENL--------KNTCLYKITMEPPRFSGKKDVPHSSKPTPNSPH 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	14/90 (16%)
		vigilin_like_KH	327..393	CDD:239087	12/70 (17%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
RGD1561230	NP_001100438.1	vigilin_like_KH	69..129	CDD:239087
		vigilin_like_KH	143..201	CDD:239087	10/27 (37%)
		KH_1	216..277	CDD:278442	14/62 (23%)
		vigilin_like_KH	386..447	CDD:239087	13/61 (21%)
		vigilin_like_KH	469..529	CDD:239087	12/63 (19%)
		vigilin_like_KH	540..601	CDD:239087	13/63 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740