DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BicC and RGD1563104

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001100437.1	Gene:	RGD1563104 / 302773	RGDID:	1563104	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	98/466 - (21%)
Similarity:	191/466 - (40%)	Gaps:	97/466 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 AIAMKLGVQNPDDLHTERFKVDRQKLEQLIKAESSIEGMNGAEYFFHDIMNTTDTYVSWPCRLK- 135
            ||..|:..:|...:    ..|...:|...|:.|....|:..|:....|:.|..:...|....:|
  Rat   443 AILNKIAERNQVSI----TMVPENELNHTIRIEGESLGVQQAKKELLDLANNLEEEYSQDIIIKH 503

  Fly   136 ------IGAKSKK--------------DPH-------VRIVGKVDQVQRAKERILSSL-DSRGTR 172
                  ||.|.::              .||       |:::|...:.::..:.:.:.| |.:...
  Rat   504 QFHHILIGQKGERVREICKKFPDVILNFPHPAEKSDIVQLIGPRYESEKCAQYLENMLTDIKENN 568

  Fly   173 VIMKMDVSYTDHSYIIGRGGNNIKRIMDDTHTHIHFPDSNRSNPTEKSNQVSLCGSLEGVERARA 237
            ..:.:.:....|..:||:|.:|||:|.:.|:|.|.||..|.:     |.:..:.|..|..|.||.
  Rat   569 YSISISIIKKLHKRLIGKGASNIKKISETTNTKISFPPENCN-----SEEFIITGYPENCEIARN 628

  Fly   238 -LVRLSTPLLISFEMPVMGP-------NKPQPDHETPYIKMIETKFNVQVIFSTRPKLHTSL--V 292
             ::.:...:..:.|..:..|       |.|:   |.....:||....:.:.|   ||..:||  |
  Rat   629 WILSIQQEIADTAEEEITIPTNLYKYLNNPK---ECLLNSIIEECGKIHLHF---PKNKSSLNKV 687

  Fly   293 LVKGSEKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVKGKNNVNLLSIMERTQTK 357
            ::.||.:   .|..|...|:..|.|..|..  .:.::.:..|:|:.:..||..|:..|.:.|.|.
  Rat   688 IIMGSVE---SVEKAKAKLLKLAEEEQAKN--YSEKIRVKSQYHQFLVNKNGGNISQICDETGTC 747

  Fly   358 IIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFPDNHNDASEIMSLNTKY- 421
            ::||:.::.:     :..:||:|..:.|...:::|     ..|:.||   .|:..:.:.:|.::
  Rat   748 VLFPNHTNKD-----QESLTITGSEESVKEVQKRL-----EDLVKDF---ENEVDDSILINRRFH 799

  Fly   422 -------------------GVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRLATPFVKP 467
                               ||.||.....||:| .:.:||.:..::   .|::.|..:..| :..
  Rat   800 HYFVMRRGQLLKEMTEEYGGVVITFSYAGRQNT-KVTIKGAKPCVE---AAKKHIKAIFEP-LGS 859

  Fly   468 EIPDYYFMPKD 478
            ::...|.:|::
  Rat   860 QVTTRYVIPQN 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	20/66 (30%)
		vigilin_like_KH	327..393	CDD:239087	14/65 (22%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
RGD1563104	NP_001100437.1	KH-I	71..136	CDD:412160
		KH-I_Vigilin_rpt5	352..420	CDD:411837
		KH-I_Vigilin_rpt6	422..489	CDD:411804	11/49 (22%)
		KH-I	494..560	CDD:412160	9/65 (14%)
		KH-I_Vigilin_rpt8	570..631	CDD:411839	20/65 (31%)
		KH-I	641..696	CDD:412160	15/63 (24%)
		KH-I	713..778	CDD:412160	15/76 (20%)
		KH-I	789..853	CDD:412160	12/67 (18%)
		KH-I	866..952	CDD:412160	1/5 (20%)
		KH-I	957..1033	CDD:412160
		KH-I	1038..1110	CDD:412160
		KH-I	1112..1177	CDD:412160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830