DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and ANKS6

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_005251850.1	Gene:	ANKS6 / 203286	HGNCID:	26724	Length:	886	Species:	Homo sapiens

Alignment Length:	971	Identity:	206/971 - (21%)
Similarity:	328/971 - (33%)	Gaps:	316/971 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LMYPSAADVAKPPMVGLEV-----EAGSIGSLSSL--------HALPSTTSVGSGA----PSETQ 57
            |:....|||.....:|..|     ..|.:|.:..|        |..||...:|.|.    |.:..
Human   129 LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193

  Fly    58 SEISSVDSDWSDIRAIAMKLGVQNPDDLH---------------TERFKVDRQKLEQLIKAESSI 107
            :.::::......:..:.|:.|.   |..|               |.|..|.:|.:|:
Human   194 ALMAAIQHGHEAVVRLLMEWGA---DPNHAARTVGWSPLMLAALTGRLGVAQQLVEK-------- 247

  Fly   108 EGMNGAEYFFHDIMNTTDTYVSWPCRLKIGAKSKKDPHVRIVGKVDQVQRAKERILSSLDSRGTR 172
                ||......::..|...|:..|:.: ......||...:..|.|:.:|..: |..:|
Human   248 ----GANPDHLSVLEKTAFEVALDCKHR-DLVDYLDPLTTVRPKTDEEKRRPD-IFHAL------ 300

  Fly   173 VIMKMDVSYTDHSYIIGRGGN--NIKRIMDDTHTHIHFPDSNRSNPTEKSNQVSLCGSLEGVERA 235
               ||              ||  .:|.|.|:..:|::..:.:.:.|.          .|..|...
Human   301 ---KM--------------GNFQLVKEIADEDPSHVNLVNGDGATPL----------MLAAVTGQ 338

  Fly   236 RALVRLSTPLLISFEMPVMGPNKPQPDHETPYIKMIETKFNVQVIFSTRPKLHTSLVLVKGSE-- 298
            .|||:    ||:.....|   :|....|....:.......|.:::         ..:|.:|::
Human   339 LALVQ----LLVERHADV---DKQDSVHGWTALMQATYHGNKEIV---------KYLLNQGADVT 387

  Fly   299 ---KESAQVRDATQLLINFACESIASQILVNVQMEIS-----PQH-----HEIVKGKNNVNLLSI 350
               |......|...||.:...|.:  ::|.:|.|:::     |.|     |..|:...::.:|
Human   388 LRAKNGYTAFDLVMLLNDPDTELV--RLLASVCMQVNKDKGRPSHQPPLPHSKVRQPWSIPVL-- 448

  Fly   351 MERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFPDNHNDASEIM 415
                      ||    :...||.....:|.|     ..:.:|:..||..|..:.|...:|..| .
Human   449 ----------PD----DKGGLKSWWNRMSNR-----FRKLKLMQTLPRGLSSNQPLPFSDEPE-P 493

  Fly   416 SLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRLATPFVKPEIPDYYFMPKDKD 480
            :|::      |:|...:..|                  .:..|..|.|..|...|......|:.
Human   494 ALDS------TMRAAPQDKT------------------SRSALPDAAPVTKDNGPGSTRGEKED- 533

  Fly   481 LNLAYRTQLTALLAG-----YVDSPKTPSLLPPSLAGQLTPYANNNHLLLNANGLATPTGVCAPT 540
                  |.||.:|..     .:.|.|..:::||.|........:::......||.|.|.....|
Human   534 ------TLLTTMLRNGAPLTRLPSDKLKAVIPPFLPPSSFELWSSDRSRTRHNGKADPMKTALP- 591

  Fly   541 QKYMQLHNSFQQAQNRSMVAGGQSNNGNYLQVPGAVAPPLKP---PTVSPRNSCSQNTSGYQSFS 602
                      |:|.....|.||           |....|::|   |:: ||
Human   592 ----------QRASRGHPVGGG-----------GTDTTPVRPVKFPSL-PR-------------- 620

  Fly   603 SSTTSLEQSYPPYAQLPGTVSSTSSSTAGSQNRAHYSPDSTYGSEGGGVGGGGG------GGARL 661
                                |..||:.:|:.|   :||.|:.||.|.||...||      ||:
Human   621 --------------------SPASSANSGNFN---HSPHSSGGSSGVGVSRHGGELLNRSGGS-- 660

  Fly   662 GRRLSDGVL----------LGLSNSNGGGGNS--GGAHLLPGSAESYRSLHYDLGGNKHSGHRAF 714
                .|.||          .||........:|  |.|   |||:.|      :|..:...|
Human   661 ----IDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPA---PGSSPS------ELPASPAGG---- 708

  Fly   715 DFDMKRALGYKAME--RTPVAGELRTPTTAWMGMGLSSTSP--APAPLENGENGAAGGGASSGWR 775
                ...:|.:.:|  :.|.:|   |.||:      .||||  .|:|...|....:...:||..|
Human   709 ----SAPVGKQKLETSKRPPSG---TSTTS------KSTSPTLTPSPSPKGHTAESSVSSSSSHR 760

  Fly   776 LPPGLGSPYGLSATTGLLDATPVNRRMQLAKHKDIQTLLTSLGLEHYIKIFVLNEIDLEVFTTLT 840
            .....|   |.|:.|             :....::..:|..|.||.|..||...|:|:|.|.|||
Human   761 QSKSSG---GSSSGT-------------ITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLT 809

  Fly   841 EENLMELGIAAFGARKKLLTAIHTLLA-----NEAACSTMPSSSSSQNSSSPRFSGSAAPG 896
            :.:|.||||...|:|:::|.||..|.|     .:....|:.:..||..||:   |.:.|||
Human   810 DGDLKELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFESSA---SNTRAPG 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	13/67 (19%)
		vigilin_like_KH	327..393	CDD:239087	13/75 (17%)
		SAM_BICC1	805..868	CDD:188919	26/67 (39%)
		SAM	807..867	CDD:197735	25/59 (42%)
ANKS6	XP_005251850.1	Ank_2	13..141	CDD:289560	4/11 (36%)
		ANK repeat	13..75	CDD:293786
		ANK	72..211	CDD:238125	15/81 (19%)
		ANK repeat	78..108	CDD:293786
		ANK repeat	110..141	CDD:293786	4/11 (36%)
		Ank_2	115..218	CDD:289560	18/91 (20%)
		ANK repeat	143..172	CDD:293786	5/28 (18%)
		ANK repeat	176..219	CDD:293786	7/45 (16%)
		ANK	193..380	CDD:238125	41/252 (16%)
		Ank_4	193..245	CDD:290365	8/54 (15%)
		ANK repeat	225..323	CDD:293786	25/134 (19%)
		Ank_4	225..277	CDD:290365	10/64 (16%)
		Ank_2	296..389	CDD:289560	24/141 (17%)
		ANK repeat	325..356	CDD:293786	10/47 (21%)
		ANK repeat	359..389	CDD:293786	4/38 (11%)
		Ank_2	364..>424	CDD:289560	11/70 (16%)
		ANK repeat	392..420	CDD:293786	6/29 (21%)
		SAM_ANKS6	772..836	CDD:188917	26/76 (34%)
		SAM	775..834	CDD:197735	24/58 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10866
eggNOG	1	0.900	-	-		E1_KOG4374
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.000