DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicC and vgln-1

DIOPT Version :9

Sequence 1:	NP_476865.1	Gene:	BicC / 34946	FlyBaseID:	FBgn0000182	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_496136.1	Gene:	vgln-1 / 174543	WormBaseID:	WBGene00007463	Length:	1220	Species:	Caenorhabditis elegans

Alignment Length:	797	Identity:	149/797 - (18%)
Similarity:	272/797 - (34%)	Gaps:	255/797 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSIGS----LSSLHALPSTTSVGSGAPSETQSEISSVDSDWSDIRAIAMK---LGVQNPDDLHTE 88
            ||.||    :...|  |:.:.|...|.|  :|::.::..|.:::.|:..|   |..:..::.:.:
Worm   507 GSKGSGVQVIRDSH--PNVSVVFPDAKS--KSDVVNIRGDKTEVDAVYKKLTALSKEYAENNYQQ 567

  Fly    89 RFKVDRQKLEQLIKAESSIEGMNGAEYFFHDIMNTTDTYVSWPCRLKIGAKSKKDPHVRIVGKVD 153
            ...:.::.|:.::       |..||.  ...:.:.|:|      |:.:......|..:.:.||..
Worm   568 TVAIFKEFLKHIV-------GKGGAS--IRKLRDETET------RIDLPESGSDDGKITVTGKQA 617

  Fly   154 QVQRA--------------------------------KERILSSLD--------------SRGTR 172
            .|::|                                ..|::|.::              |..|:
Worm   618 NVEKAVAQLNKIQEELANVAEESIEIPQKVQSRFFGNGRRLISDIEDECGGVHIRFPSEKSESTK 682

  Fly   173 VIMK-------------------MDVSYTD---------HSYIIGRGGNNIKRIMDDTHTHIHFP 209
            |.::                   .:.:|.:         |.::||:||:.|.::.|..:..:.||
Worm   683 VTIRGPAGDVAKAVGLLSALAKDKEENYVEDTVKAKPEFHRFLIGKGGSKIAKLRDTLNVRVMFP 747

  Fly   210 DSNRSNPTEKSNQVSLCGSLEGVERAR-----ALVRLSTPLLISFEMPVMGPNKPQPDHETPY-- 267
               :....||.. :.|.|..|.|.:|:     |:.:||..:.|...:        .|.:...:
Worm   748 ---KEGDAEKET-IHLLGKKEDVPKAKAALEDAIKQLSETVDIKITV--------DPKYYKNFLA 800

  Fly   268 -----IKMIETKFNVQVIFSTRPKLHTSLVLVKGSEKESAQVRDATQLLINFACESIASQILVNV 327
                 :|.|:.:....||...:....:|.|.::||:    |..:|.:..|....|....||..||
Worm   801 RGAALVKEIQEQNGGVVISFPKNGTDSSEVSIRGSK----QCVEAAKNRIEDVVEDYEKQITDNV 861

  Fly   328 QMEISPQHHEIVKGKNNVNLLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQL 392
              .|..|.|..:.......:..:..:....|.||:..:...:  ...|||:|||...|..|::.|
Worm   862 --TIPAQFHRGLLAGRGAKIHELQSKYNVSIRFPNNREEGSE--GSDQVTVSGRDTKVEEAKEAL 922

  Fly   393 LGNLPVALIFDFP-DNHND-----ASEIMSLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKI- 450
            |..:|::.:...| |.|..     ...:..|...|.|.|::  .:..|:..|.|.|..:.:|:.
Worm   923 LAMVPISKVIQLPVDMHRSIIGRGGETVRKLMQDYDVNISI--PKDNSSEDITVTGQTENVDQAL 985

  Fly   451 ---------YEARQEILRLATPFVKPEIP-DYYFMPKDKDLNLAYRTQLTALLAGY---VDSPKT 502
                     |||:.|..:|....:...:| ||:    .|.:.....| :|||...|   ::.|:
Worm   986 EALRGKLGEYEAQAEDRKLKQWSMSINVPTDYH----QKIIGQRGAT-ITALKEKYGVIINVPR- 1044

  Fly   503 PSLLPPSLAGQLTPYANNNHLLLNANGLATPTGVCAPTQKYM--QLHNSFQQ-----AQNRSMVA 560
                            .:.:..:...|.......||...:.|  :|.:.|.|     |:....:.
Worm  1045 ----------------EDGNETITIQGYEEKANECAAAIEEMISELRSMFTQEISLDARYHPRLI 1093

  Fly   561 GGQSNN-----GNY---LQVP--GAVAPPL-------------------------------KPPT 584
            |.:..|     .:|   :::|  ||..|.|                               :...
Worm  1094 GQRGKNLKKVMEDYRVEIRLPRQGAEDPNLVVVAGKDENDVYDCIDHLRAEEEEFLLDNVERTQY 1158

  Fly   585 VSPRNSCSQNTSGYQSFSSSTTSLEQSYPPY-------AQLPGTVSSTSSSTAGSQNRAHYSPDS 642
            :|||...|.||..:|    ..||::....|:       .|.|....:..||.|
Worm  1159 MSPRQQESNNTRHHQ----QPTSVQMKGAPWQLDLGSSEQFPDMGPAAGSSAA------------ 1207

  Fly   643 TYGSEGGGVGGGGGGGA 659
                    |||.|..|:
Worm  1208 --------VGGAGAWGS 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	vigilin_like_KH	174..240	CDD:239087	18/98 (18%)
		vigilin_like_KH	327..393	CDD:239087	15/65 (23%)
		SAM_BICC1	805..868	CDD:188919
		SAM	807..867	CDD:197735
vgln-1	NP_496136.1	vigilin_like_KH	137..198	CDD:239087
		vigilin_like_KH	209..270	CDD:239087
		vigilin_like_KH	281..341	CDD:239087
		vigilin_like_KH	350..407	CDD:239087
		vigilin_like_KH	420..481	CDD:239087
		vigilin_like_KH	492..553	CDD:239087	12/49 (24%)
		vigilin_like_KH	568..626	CDD:239087	12/72 (17%)
		vigilin_like_KH	638..696	CDD:239087	5/57 (9%)
		vigilin_like_KH	712..774	CDD:239087	16/65 (25%)
		vigilin_like_KH	786..847	CDD:239087	12/72 (17%)
		vigilin_like_KH	858..923	CDD:239087	16/68 (24%)
		vigilin_like_KH	929..989	CDD:239087	12/61 (20%)
		vigilin_like_KH	1008..1068	CDD:239087	13/81 (16%)
		vigilin_like_KH	1079..1142	CDD:239087	10/62 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910