Protein Alignment BicC and anks6

DIOPT Version :10

• Sequence 1: NP_476865.1
• Gene: BicC / 34946
• FlyBaseID: FBgn0000182
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_001123839.1
• Gene: anks6 / 100170596
• XenbaseID: XB-GENE-5969671
• Length: 903
• Species: Xenopus tropicalis
• Alignment Length: 1081
• Identity: 212/1081 - (19%)
• Similarity: 353/1081 - (32%)
• Gaps: 410/1081 - (37%)

  Fly    12 YPSAADVAKPPMVGLEVEAGS------IGSLSSLHAL-------PSTTSV---GSGAPSETQSEI 60
            |.||..:.:|   ..|...||      ||:.|||..:       |.|..:   |.|.|...|..:
 Frog    30 YESAKRLLEP---SSETFGGSVSSQLAIGARSSLSCVGVRQGDGPGTVDLPGSGGGGPEPPQVPV 91

  Fly    61 SSVDSDWSDIRAIAMKLGVQNPDDLHTERFKVDRQKLEQLIKAESSIEGMNGAEYFFHDIMNTTD 125
            ...|.|.:....:|.. |...|    ..||         |::..:|::..|  .|.:..:|....
 Frog    92 DCTDEDGNTALQLAAG-GGHEP----IVRF---------LLRKGASVDSRN--HYGWTPLMQAAR 140

  Fly   126 TYVSWPCRLKIGAKSKKDPHVRIV-------GKVDQVQRAKERILSSLDSRGTRVIMKMDVSYTD 183
            |                 .|:.:.       ..|:...|....:|:
 Frog   141 T-----------------GHLNVAMILLENGADVNAQNRLGASVLT------------------- 169

  Fly   184 HSYIIGRGG--NNIKRIMD-----DTHTHIHFPDSNRSNPTEKSNQVSLCGSLEGVERARALVRL 241
               :..|||  |.:|.::|     |.:.|...            |.||..|.:|.:....||:..
 Frog   170 ---VASRGGHVNVVKELLDHGAFVDNYDHFDV------------NMVSRNGEIEDMPDITALMTA 219

  Fly   242 STPLLISFEMPVMGPNKPQPDHETPYIKMIE-----------TKFNVQVIFSTRPKLHTSLVLV- 294
            :                 |..||.....:::           |.:|..::.:...::..:..||
 Frog   220 T-----------------QHAHEAVVRLLLDWGADVNYRVKTTGWNPLMLAALHGRVSVAQQLVD 267

  Fly   295 KGSEKESAQVRDAT--QLLINFACESIASQI--LVNVQMEISPQ------HHEIVKGKNNVNLLS 349
            :|::.:...:.|.|  ::.:||..:.:...:  :..::.:...:      .|.:..|  ||.|:.
 Frog   268 RGADPDQVNILDKTPFEIALNFKHKDMKDYLDSITKIRPKTDEEKRRPDIFHAVKMG--NVQLVK 330

  Fly   350 IMERTQTKIIFPDLSDMN------VKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFPD-N 407
            :       ||..|.|.:|      ..||..:.||  |:::.|.|            |:....| |
 Frog   331 L-------IIDEDPSQVNAVNADGASPLMIAAVT--GKLELVQL------------LVDKNADIN 374

  Fly   408 HNDA---------------SEIMSLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEI 457
            ..|:               .|::......|..:|||.|...:...:|:        .:.:...|:
 Frog   375 KQDSVHAWTALMQATYHGNKEVVIFLLNQGADVTLRAKNGYTAFDLVM--------LLNDPDTEL 431

  Fly   458 LRLATPFVKPEIPDYYFMPKDKDLNLAYRTQLTALLAGYVDSPKTPSLLPP---SLAG------- 512
            :||...|...       |.|:|....: ::||.:.::      |....:||   ..||
 Frog   432 VRLLASFCLQ-------MDKEKSKQKS-KSQLLSTMS------KQSFTIPPPTEDKAGLKSWWNR 482

  Fly   513 --------QLTP-----YANNNHLLLNANGLAT--------------------PTGVCAPTQKYM 544
                    :||.     ::.|..:.|..|..|:                    .|.....|:|..
 Frog   483 MSNRFRKLKLTQTLRHGFSTNRLVPLTENASASLDSMLRFTSQPDASSPRRPDSTTAWTATRKDS 547

  Fly   545 QLHNSFQQAQNRSMVAGGQSNNG-NYLQVPG----AVAPPLKPP--------------------- 583
            .|.::  :.:|..::.....||| .:.::|.    ||.||..||
 Frog   548 GLGST--KIENDDILLTTMLNNGAPFAKLPNDKLKAVIPPFLPPSNFDLWNSDRSRISRDGKMEQ 610

  Fly   584 ---TVSPRNS-CSQNTSGYQSFSS-STTSLEQSYPPYAQLPGTVSSTSSSTAGSQNRAHYSPDST 643
               :::||:| .|.|:||....:| |.|.....:|...:.|     ||.|.:||.|   :||.|
 Frog   611 TRASMTPRHSKPSFNSSGNSDITSVSRTPRNVKFPSLPRSP-----TSPSNSGSFN---HSPHS- 666

  Fly   644 YGSEGGGVGGGGGGGARLGRRLSDGVLLGLSNSNGGGGNSGGAHLLPGSAE-------SYRSLHY 701
                                                   ||||:.:.||||       :.|....
 Frog   667 ---------------------------------------SGGANSVSGSAENVLSQIAAQRKKAA 692

  Fly   702 DLGGNKHSGHRAFDFDMKRALGYKAMERTPVA-GEL--------RTPTTAWMGMGLSSTS----- 752
            :|...|.:...:.:......:........|:. |.|        |.|:      |.||||
 Frog   693 NLSEQKKAQLHSPNITAAATIVLDQQSSNPIINGHLPKKIEILKRPPS------GASSTSKSTSP 751

  Fly   753 ---PAPAPLENG-------------ENGAAGGGASSGWRLPPGLGSPYGLSATTGLLDATPVNRR 801
               |:|:|...|             :...:.||:|||
 Frog   752 TLTPSPSPTPKGRLADSSMSSSSSHKQSKSSGGSSSG---------------------------- 788

  Fly   802 MQLAKHKDIQTLLTSLGLEHYIKIFVLNEIDLEVFTTLTEENLMELGIAAFGARKKLLTAIHTLL 866
             .:....::..:|..|.||.|..||...|:|:|.|.|||:.:|.||||...|:|:::|.||..|.
 Frog   789 -TITDEDELSAILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELN 852

  Fly   867 A-----NEAACSTMPSSSSSQNSSSPRFSGSAAPGAERRPS 902
            |     .:....|:.:..||..||:   |.:...||.:.||
 Frog   853 AGKGRERQILQETIHNFHSSFESSA---SNTQPMGAHQSPS 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BicC	NP_476865.1	KH-I_BICC1_rpt1	85..166	CDD:411848	12/87 (14%)
		KH-I_BICC1_rpt2	171..240	CDD:411849	15/75 (20%)
		KH-I_BICC1_rpt3	325..393	CDD:411850	17/79 (22%)
		SAM_BICC1	805..868	CDD:188919	26/67 (39%)
anks6	NP_001123839.1	ANKYR	<91..316	CDD:440430	44/308 (14%)
		ANK repeat	97..128	CDD:293786	8/44 (18%)
		ANK repeat	130..161	CDD:293786	5/47 (11%)
		ANK repeat	163..188	CDD:293786	7/46 (15%)
		ANK repeat	246..276	CDD:293786	4/29 (14%)
		ANKYR	265..>435	CDD:440430	37/200 (19%)
		ANK repeat	346..377	CDD:293786	10/44 (23%)
		ANK repeat	380..410	CDD:293786	3/29 (10%)
		SAM_ANKS6	789..853	CDD:188917	25/63 (40%)