DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10839 and Lrrc6

DIOPT Version :9

Sequence 1:	NP_001246039.1	Gene:	CG10839 / 34944	FlyBaseID:	FBgn0028858	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_062330.1	Gene:	Lrrc6 / 54562	MGIID:	1859553	Length:	473	Species:	Mus musculus

Alignment Length:	175	Identity:	45/175 - (25%)
Similarity:	81/175 - (46%)	Gaps:	28/175 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KDALAKWEDRNKQPAATATEIGLQFQYPPIEKMDPILNSLTECQKLSLSSNMIEKITGISGMKNL 72
            :|.:.:..:.|.....:..|:.|..|  .||:::.|.....:.:.|.|.:|:|.||..:|.:|.|
Mouse     6 EDLIRRNAEHNDCVIFSLEELSLHQQ--EIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKL 68

  Fly    73 KVLSLARNNLKTLNGIEPLADTLEELWVSYNNIEKTKPLESMKALRVFYISFNMIKDWTEFMRMG 137
            :.|:||.||::.:..:|. .:.|.:|.::.|.|.:   |.|:|.|     :.|:
Mouse    69 EYLNLALNNIERIENLEG-CEWLTKLDLTVNFIGE---LSSVKTL-----THNI----------- 113

  Fly   138 VPPNLSEITFVGNPLNENMDQSAFTAEAVRRLPNMKKLDGEPVIR 182
               :|.|:..:|||.   .|...:....|..|..:|.|||:.:.|
Mouse   114 ---HLKELFLMGNPC---ADFDGYRQFVVVTLQQLKWLDGKEIER 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10839	NP_001246039.1	LRR_RI	<37..129	CDD:238064	27/91 (30%)
		LRR_4	48..90	CDD:289563	14/41 (34%)
		leucine-rich repeat	50..71	CDD:275380	7/20 (35%)
		LRR_8	51..105	CDD:290566	18/53 (34%)
		leucine-rich repeat	72..94	CDD:275380	7/21 (33%)
		leucine-rich repeat	95..116	CDD:275380	6/20 (30%)
		leucine-rich repeat	117..141	CDD:275380	2/23 (9%)
		leucine-rich repeat	142..171	CDD:275380	8/28 (29%)
Lrrc6	NP_062330.1	LRR_4	22..64	CDD:289563	12/43 (28%)
		LRR 1	22..43		6/22 (27%)
		leucine-rich repeat	23..45	CDD:275378	6/23 (26%)
		LRR 2	45..66		7/20 (35%)
		LRR_8	46..98	CDD:290566	17/52 (33%)
		LRR_4	46..86	CDD:289563	14/39 (36%)
		leucine-rich repeat	46..67	CDD:275378	7/20 (35%)
		LRR 3	67..88		7/21 (33%)
		leucine-rich repeat	68..89	CDD:275378	7/21 (33%)
		LRR 4	89..110		8/28 (29%)
		leucine-rich repeat	90..114	CDD:275378	9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810