DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10839 and DNAAF11

DIOPT Version :9

Sequence 1:	NP_001246039.1	Gene:	CG10839 / 34944	FlyBaseID:	FBgn0028858	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	XP_006716601.2	Gene:	DNAAF11 / 23639	HGNCID:	16725	Length:	472	Species:	Homo sapiens

Alignment Length:	177	Identity:	44/177 - (24%)
Similarity:	76/177 - (42%)	Gaps:	28/177 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PTTLKDALAKWEDRNKQPAATATEIGLQFQYPPIEKMDPILNSLTECQKLSLSSNMIEKITGISG 68
            |...:|.:.:..:.|.....:..|:.|..|  .||:::.|.....:.:.|.|.:|:|.||..:|.
Human     8 PHVTEDLIRRNAEHNDCVIFSLEELSLHQQ--EIERLEHIDKWCRDLKILYLQNNLIGKIENVSK 70

  Fly    69 MKNLKVLSLARNNLKTLNGIEPLADTLEELWVSYNNIEKTKPLESMKALRVFYISFNMIKDWTEF 133
            :|.|:.|:||                       .|||||.:.||..:.|....::.|.|.:.:..
Human    71 LKKLEYLNLA-----------------------LNNIEKIENLEGCEELAKLDLTVNFIGELSSI 112

  Fly   134 MRMGVPPNLSEITFVGNPLNENMDQSAFTAEAVRRLPNMKKLDGEPV 180
            ..:....:|.|:..:|||. .:.|.  :....|..||.:|.|||:.:
Human   113 KNLQHNIHLKELFLMGNPC-ASFDH--YREFVVATLPQLKWLDGKEI 156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10839	NP_001246039.1	LRR_RI	<37..129	CDD:238064	25/91 (27%)
		LRR_4	48..90	CDD:289563	12/41 (29%)
		leucine-rich repeat	50..71	CDD:275380	7/20 (35%)
		LRR_8	51..105	CDD:290566	13/53 (25%)
		leucine-rich repeat	72..94	CDD:275380	4/21 (19%)
		leucine-rich repeat	95..116	CDD:275380	7/20 (35%)
		leucine-rich repeat	117..141	CDD:275380	3/23 (13%)
		leucine-rich repeat	142..171	CDD:275380	8/28 (29%)
DNAAF11	XP_006716601.2	LRR_RI	<5..200	CDD:238064	44/177 (25%)
		leucine-rich repeat	29..51	CDD:275378	6/23 (26%)
		LRR_8	52..104	CDD:290566	20/74 (27%)
		LRR_4	52..92	CDD:289563	18/62 (29%)
		leucine-rich repeat	52..73	CDD:275378	7/20 (35%)
		leucine-rich repeat	74..95	CDD:275378	11/43 (26%)
		leucine-rich repeat	96..120	CDD:275378	3/23 (13%)
		LRRcap	134..152	CDD:197729	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810