DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10839 and DNAAF1

DIOPT Version :9

Sequence 1:	NP_001246039.1	Gene:	CG10839 / 34944	FlyBaseID:	FBgn0028858	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	XP_011521155.1	Gene:	DNAAF1 / 123872	HGNCID:	30539	Length:	772	Species:	Homo sapiens

Alignment Length:	167	Identity:	40/167 - (23%)
Similarity:	80/167 - (47%)	Gaps:	33/167 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQFQYPPIEKMDPILNSLTECQKLSLSSNMIEKITGISGMKNLKVLSLARNNLKTLNGIE--PLA 92
            |..|...|:|::. |.:.||.:.|.|..|::.||..:..::.|..|:|:.|.:||:..:.  |:.
Human   134 LWLQSNGIQKIEN-LEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVL 197

  Fly    93 DTLEELWVSYNNIEKTKPLESMK---ALRVFYISFNMIKDWTEFMRMGVPPNLSEITFVGNPLNE 154
            :||:   :::|::|..:.::.::   .|.|..:|.|.:.|......:...|:|..:..:|||:
Human   198 NTLQ---MAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPV-- 257

  Fly   155 NMDQSAFTAEAVRRLPNMKK-----------LDGEPV 180
                       :|::||.::           ||..||
Human   258 -----------IRQIPNYRRTVTVRLKHLTYLDDRPV 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10839	NP_001246039.1	LRR_RI	<37..129	CDD:238064	25/96 (26%)
		LRR_4	48..90	CDD:289563	13/43 (30%)
		leucine-rich repeat	50..71	CDD:275380	5/20 (25%)
		LRR_8	51..105	CDD:290566	15/55 (27%)
		leucine-rich repeat	72..94	CDD:275380	7/23 (30%)
		leucine-rich repeat	95..116	CDD:275380	3/23 (13%)
		leucine-rich repeat	117..141	CDD:275380	5/23 (22%)
		leucine-rich repeat	142..171	CDD:275380	5/28 (18%)
DNAAF1	XP_011521155.1	leucine-rich repeat	111..130	CDD:275380
		LRR_4	129..171	CDD:289563	12/37 (32%)
		LRR_8	151..207	CDD:290566	17/58 (29%)
		LRR_4	151..192	CDD:289563	13/40 (33%)
		leucine-rich repeat	153..174	CDD:275380	5/20 (25%)
		LRR_4	173..215	CDD:289563	11/44 (25%)
		leucine-rich repeat	175..196	CDD:275380	6/20 (30%)
		LRR_8	195..257	CDD:290566	14/64 (22%)
		leucine-rich repeat	197..221	CDD:275380	4/26 (15%)
		LRR_4	221..263	CDD:289563	11/54 (20%)
		leucine-rich repeat	222..243	CDD:275380	5/20 (25%)
		leucine-rich repeat	247..274	CDD:275380	7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810