DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10839 and CNTRL

DIOPT Version :9

Sequence 1:	NP_001246039.1	Gene:	CG10839 / 34944	FlyBaseID:	FBgn0028858	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	XP_011516468.1	Gene:	CNTRL / 11064	HGNCID:	1858	Length:	2340	Species:	Homo sapiens

Alignment Length:	184	Identity:	49/184 - (26%)
Similarity:	91/184 - (49%)	Gaps:	23/184 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KPTTLKDALAKWEDRNKQPAATATEIGLQFQYPPIEKMDPILNSLTECQK---LSLSSNMIEKIT 64
            |..|.:|.||..:..|   .:.:.:.|.:|:|         :.:|.:|.|   |:||.|:|.||.
Human    89 KKLTKQDNLALIKSLN---LSLSKDGGKKFKY---------IENLEKCVKLEVLNLSYNLIGKIE 141

  Fly    65 GISGMKNLKVLSLARNNLKTLNGIEPLADTLEELWVSYNNIEKTKPL---ESMKALRVFYISFNM 126
            .:..:..|:.|:|:.|.:..:.|||.:.: |::|.::.|.||.. |:   :.:|:|||..:..|.
Human   142 KLDKLLKLRELNLSYNKISKIEGIENMCN-LQKLNLAGNEIEHI-PVWLGKKLKSLRVLNLKGNK 204

  Fly   127 IKDWTEFMRMGVPPNLSEITFVGNPLNENMDQSAFTAEAVRRLPNMKKLDGEPV 180
            |....:..::....:|..:..|.||:........||   :..|.:::.|:|:||
Human   205 ISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT---IFHLRSLESLEGQPV 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10839	NP_001246039.1	LRR_RI	<37..129	CDD:238064	29/97 (30%)
		LRR_4	48..90	CDD:289563	15/44 (34%)
		leucine-rich repeat	50..71	CDD:275380	9/23 (39%)
		LRR_8	51..105	CDD:290566	18/56 (32%)
		leucine-rich repeat	72..94	CDD:275380	7/21 (33%)
		leucine-rich repeat	95..116	CDD:275380	6/23 (26%)
		leucine-rich repeat	117..141	CDD:275380	5/23 (22%)
		leucine-rich repeat	142..171	CDD:275380	7/28 (25%)
CNTRL	XP_011516468.1	leucine-rich repeat	100..119	CDD:275378	4/30 (13%)
		LRR_4	126..167	CDD:289563	14/40 (35%)
		leucine-rich repeat	127..148	CDD:275380	7/20 (35%)
		LRR_8	148..205	CDD:290566	18/58 (31%)
		leucine-rich repeat	149..170	CDD:275380	7/20 (35%)
		LRR_4	169..213	CDD:289563	12/45 (27%)
		leucine-rich repeat	171..194	CDD:275380	6/23 (26%)
		leucine-rich repeat	195..219	CDD:275380	5/23 (22%)
		leucine-rich repeat	220..246	CDD:275380	7/28 (25%)
		SMC_prok_B	<435..1119	CDD:274008
		DUF342	<513..610	CDD:302792
		Pro-rich	<1176..1299	CDD:291893
		COG4372	1320..>1602	CDD:226809
		Mplasa_alph_rch	1525..2221	CDD:275316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810