DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10839 and Lrrc49

DIOPT Version :9

Sequence 1:	NP_001246039.1	Gene:	CG10839 / 34944	FlyBaseID:	FBgn0028858	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_663591.3	Gene:	Lrrc49 / 102747	MGIID:	2442689	Length:	752	Species:	Mus musculus

Alignment Length:	190	Identity:	46/190 - (24%)
Similarity:	85/190 - (44%)	Gaps:	47/190 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQFQYPPIEKMDPILNSLTECQKLSLSSNMIEKITGISGMKNLKVLSLARNNLKTLNGIEPL--- 91
            |.||:..|.::..|.| |.....|.|..|.||:|:|:|.:|:|:||.|.:|.:|.::.:|.|
Mouse   183 LNFQHNFITRIQNISN-LQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNL 246

  Fly    92 ----------------------------------------ADTLEELWVSYNNIEKTKPLESMKA 116
                                                    .|:|.||.:.:|.|...:.::::..
Mouse   247 DVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPC 311

  Fly   117 LRVFYISFNMIKDWTEFMRMGVPPNLSEITFVGNPLNENMDQSAFTAEAVRRLPNMKKLD 176
            |:..::|||.|..:.....:....:||:|||.|||:.:   :|.:....::.:..:::||
Mouse   312 LQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQ---ESWYKHTVLQNMMQLRQLD 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10839	NP_001246039.1	LRR_RI	<37..129	CDD:238064	32/134 (24%)
		LRR_4	48..90	CDD:289563	15/41 (37%)
		leucine-rich repeat	50..71	CDD:275380	8/20 (40%)
		LRR_8	51..105	CDD:290566	22/96 (23%)
		leucine-rich repeat	72..94	CDD:275380	8/64 (13%)
		leucine-rich repeat	95..116	CDD:275380	5/20 (25%)
		leucine-rich repeat	117..141	CDD:275380	5/23 (22%)
		leucine-rich repeat	142..171	CDD:275380	9/28 (32%)
Lrrc49	NP_663591.3	leucine-rich repeat	160..177	CDD:275380
		LRR_4	178..219	CDD:289563	14/36 (39%)
		leucine-rich repeat	180..201	CDD:275380	7/18 (39%)
		LRR_4	200..242	CDD:289563	15/41 (37%)
		leucine-rich repeat	202..223	CDD:275380	8/20 (40%)
		LRR_8	222..278	CDD:290566	9/55 (16%)
		LRR_4	222..264	CDD:289563	9/41 (22%)
		leucine-rich repeat	224..245	CDD:275380	8/20 (40%)
		LRR_4	244..286	CDD:289563	0/41 (0%)
		leucine-rich repeat	246..267	CDD:275380	0/20 (0%)
		LRR_8	268..322	CDD:290566	10/53 (19%)
		leucine-rich repeat	268..289	CDD:275380	0/20 (0%)
		LRR_4	289..329	CDD:289563	10/39 (26%)
		leucine-rich repeat	290..311	CDD:275380	5/20 (25%)
		leucine-rich repeat	312..336	CDD:275380	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910