DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4793 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_723941.2	Gene:	CG4793 / 34941	FlyBaseID:	FBgn0028514	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	353	Identity:	83/353 - (23%)
Similarity:	148/353 - (41%)	Gaps:	84/353 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SMAKECVQRNRCRIGTETGRPIIDFRGLNNGNQGCESGQTC------CPKTEILQYP-VQADNQP 81
            |:.:.|.::..|..|::              .:.|:.|..|      |.....::.| .:.|.|
Mouse   505 SLPRVCDRQPDCLNGSD--------------EEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQ- 554

  Fly    82 LPTEC--------------GHVNRIGVGFTITNARDIAQKGELPWMVALLDSRSRLPLGGGSLIT 132
              ::|              |..:|| ||.|:::      :||.||. |.|..|.| .:.||:||.
Mouse   555 --SDCRDGSDEQHCDCGLQGLSSRI-VGGTVSS------EGEWPWQ-ASLQIRGR-HICGGALIA 608

  Fly   133 RDVVLTSS----TKTLEVPEKYLIVRA---------GEWDFESITEERAHEDVAIRKIVRHTNLS 184
            ...|:|::    ..::..|:.:.:...         ||..|:            :.::..|....
Mouse   609 DRWVITAAHCFQEDSMASPKLWTVFLGKMRQNSRWPGEVSFK------------VSRLFLHPYHE 661

  Fly   185 VENGANNAALLFLARPLKLDHHIGLICLPPPNRNFIHNR-CIVSGWGKKTALDNSYMNILKKIEL 248
            .::...:.|||.|..|:.....:..:|||..:..|...: |.::|||.:.. .....|.|:|:::
Mouse   662 EDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQRE-GGPVSNTLQKVDV 725

  Fly   249 PLVDRSVCQTKLQGPYGKDFILDNSLICAGGEPG-KDTCKGDGGAPLACPLQSDPNRYELLGIVN 312
            .||.:.:|....:      :.:...::|||...| ||.|:||.|.||.|  :....|:.|.|:|:
Mouse   726 QLVPQDLCSEAYR------YQVSPRMLCAGYRKGKKDACQGDSGGPLVC--REPSGRWFLAGLVS 782

  Fly   313 FGFGCGGP-LPAAYTDVSQIRSWIDNCI 339
            :|.|||.| ....||.|:::.:||...:
Mouse   783 WGLGCGRPNFFGVYTRVTRVINWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4793	NP_723941.2	Tryp_SPc	105..337	CDD:238113	65/247 (26%)
CG4793	NP_723941.2	Tryp_SPc	105..335	CDD:214473	63/245 (26%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060	4/33 (12%)
		Ldl_recept_a	529..566	CDD:278486	6/39 (15%)
		Tryp_SPc	576..806	CDD:214473	68/259 (26%)
		Tryp_SPc	577..809	CDD:238113	69/261 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910