DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4793 and HSPG2

DIOPT Version :9

Sequence 1:NP_723941.2 Gene:CG4793 / 34941 FlyBaseID:FBgn0028514 Length:910 Species:Drosophila melanogaster
Sequence 2:XP_011539620.1 Gene:HSPG2 / 3339 HGNCID:5273 Length:4574 Species:Homo sapiens


Alignment Length:1250 Identity:228/1250 - (18%)
Similarity:361/1250 - (28%) Gaps:536/1250 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 FSR-IQALFCGGSMAKECVQRNRCRIGTETGRPIIDFRGLNNGNQGCESGQTCCPKTEILQYPV- 75
            ||| .::|..||.....|......:...:.|...:       ||...:.|| |.|:|.  |.|: 
Human  1807 FSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYV-------GNPSVQGGQ-CLPETN--QAPLV 1861

  Fly    76 ---------------------------------QADNQPLP--TECGH---------VNRIGVGF 96
                                             :.|.:|:|  |:..|         |.....|.
Human  1862 VEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGV 1926

  Fly    97 TITNARDIAQ----KGEL--------PWMVALLDSRSRLPLGGGSLITRDVVLTSSTKTLEVPEK 149
            .|...|::.|    :.||        |..|.:.:.||:....|..:   ..:.|:.:|:    ..
Human  1927 YICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADV---TFICTAKSKS----PA 1984

  Fly   150 YLIVRAGEW-------------DFESITEERAHEDVAIRKIVRHTNLS-----VENGAN------ 190
            |.:|    |             ||..|.            .:|:..||     |..|:|      
Human  1985 YTLV----WTRLHNGKLPTRAMDFNGIL------------TIRNVQLSDAGTYVCTGSNMFAMDQ 2033

  Fly   191 NAALLF------LARPLKLDHHIGLICLPPPNRNFIHNRCIVSG-------W-----GKKTALDN 237
            ..|.|.      |:.|:...|...|...|.....|   ||..:|       |     |:..|...
Human  2034 GTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEF---RCSATGSPTPTLEWTGGPGGQLPAKAQ 2095

  Fly   238 SYMNILKKIELPLVDRSVCQTKLQGPYGKDFILDNSLIC-AGGEPGKDTCKG-----DGGAPLAC 296
            .:..||:   ||.|:.:.     |..|          :| |....|:...:.     .||.|   
Human  2096 IHGGILR---LPAVEPTD-----QAQY----------LCRAHSSAGQQVARAVLHVHGGGGP--- 2139

  Fly   297 PLQSDPNRYELLGIVNFGFGC---------------GGPLP----AAYTDVSQIRSWIDNCIQAE 342
            .:|..|.|.::.........|               ||.||    :..||::.:  .|.....|:
Human  2140 RVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATL--LIPAITTAD 2202

  Fly   343 AVHY-----SPQ-----------LGNVGQSPAP--LDRYIPNIGLETQNEVHSPVQGSLHNVV-- 387
            |..|     ||.           |.....||.|  ::...|::......:::..|.||.|..|  
Human  2203 AGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTW 2267

  Fly   388 YQTGGVGYIRGMGQGTAFQG---------PVQVGELI--------PNEGTVSGGLVYDSNEIQKF 435
            |:.||     .:...|...|         |...||.:        |.|.:::..:::.:      
Human  2268 YRRGG-----SLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGT------ 2321

  Fly   436 NQGGIYIPHVGQGNSDNRYYPNPEIGAVPVGNPI---PNEGNAFGGRGYDFN---------EIQK 488
            :.|..|.|..|.                  ..||   |:..:...|:..|.|         ::..
Human  2322 HSGPSYTPVPGS------------------TRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTW 2368

  Fly   489 HNQG------------------------GRYIPHVGHGNGP--------------NAPKEPLKIG 515
            |.:|                        |.|:.||...:||              ..|..|::|.
Human  2369 HKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE 2433

  Fly   516 GNIPNVGQGN-------------------------------RGNR---YDLNP-EIG-------- 537
            .:...|.:|.                               ||:|   :..:| :.|        
Human  2434 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN 2498

  Fly   538 ------------------AVPVGN--PI---PNEGNAFGGRGYDLN---------EIQKHNQGGR 570
                              |.|.|:  ||   |:......|:..|||         ::..|.:||.
Human  2499 GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2563

  Fly   571 Y-IPHVGHGN--------------------GPNAPKE-----LLKIGGNIPNVG----------- 598
            . :.|..||:                    |.:.|.|     .::..|::|.:|           
Human  2564 LPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSS 2628

  Fly   599 -QGNRGNIYDPNPEI--------------GAVPVGNPI-----------PNEGNAF-----GGRG 632
             |...|...|.|..:              |::|..:.:           |.:...:     |..|
Human  2629 SQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSG 2693

  Fly   633 YD----LNEIQK-----HNQGGRYIPHV---------GHGNGPN---APKEP-----LKIGGNIP 671
            ..    |..||:     |:||..|...:         ||....|   |.:.|     .|.||::|
Human  2694 TQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP 2758

  Fly   672 NVGQ--GNRGNIYDPNPEIGAVPVGNPIPNEGNAFGGRGYDLNEIQKHNQGGRYIPHVGHGNGPN 734
            :..|  |:|..|    |::.....|..:.:..|..|.|...| .:.....|..::|.|       
Human  2759 SRHQIVGSRLRI----PQVTPADSGEYVCHVSNGAGSRETSL-IVTIQGSGSSHVPSV------- 2811

  Fly   735 APKEPLKIGGNIPNVGQGNRGNRYDPNPEIGAVPV--------GNPIPNEGNAFGGRGYDLNEIQ 791
              ..|::|..:.|.|.:   |...|.|..:...|.        |..:|:.....|      :.::
Human  2812 --SPPIRIESSSPTVVE---GQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHG------SHLR 2865

  Fly   792 KHN----QGGRYI-------------------PHVGHGNGPNAP--KEPLKIGGNIPNVGQGNRG 831
            .|.    ..|.|:                   |..|   .|:||  ..|::|..:..:|.:   |
Human  2866 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAG---SPSAPGSSMPIRIESSSSHVAE---G 2924

  Fly   832 NRYDLN---PEIGHA 843
            ...|||   |...||
Human  2925 ETLDLNCVVPGQAHA 2939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4793NP_723941.2 Tryp_SPc 105..337 CDD:238113 60/310 (19%)
Tryp_SPc 105..335 CDD:214473 59/308 (19%)
HSPG2XP_011539620.1 SEA 80..193 CDD:214554
LDLa 216..251 CDD:238060
LDLa 302..336 CDD:238060
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
IG 431..507 CDD:214652
Ig_Perlecan_D2_like 438..515 CDD:143220
LamB 608..734 CDD:214597
EGF_Lam 782..824 CDD:238012
EGF_Lam 831..888 CDD:238012
Laminin_EGF 897..939 CDD:278482
LamB 1003..1130 CDD:214597
EGF_Lam 1176..1225 CDD:238012
EGF_Lam 1227..1282 CDD:238012
Laminin_EGF 1293..1340 CDD:278482
LamB 1574..1699 CDD:214597
EGF_Lam 1746..1794 CDD:238012
Laminin_EGF 1796..1851 CDD:278482 12/51 (24%)
Ig_2 1866..1958 CDD:290606 14/91 (15%)
IG_like 1866..1946 CDD:214653 12/79 (15%)
Ig3_Perlecan_like 1954..2039 CDD:143231 19/107 (18%)
IG 1961..2040 CDD:214652 19/101 (19%)
I-set 2049..2133 CDD:254352 21/104 (20%)
Ig 2063..2133 CDD:299845 17/90 (19%)
I-set 2139..2225 CDD:254352 17/90 (19%)
IGc2 2153..2215 CDD:197706 13/63 (21%)
IG_like 2240..2317 CDD:214653 16/81 (20%)
IGc2 2247..2307 CDD:197706 13/64 (20%)
IG 2341..2418 CDD:214652 12/76 (16%)
IGc2 2348..2408 CDD:197706 9/59 (15%)
IG_like 2434..2508 CDD:214653 7/73 (10%)
IGc2 2441..2500 CDD:197706 6/58 (10%)
IG_like 2530..2607 CDD:214653 14/76 (18%)
IGc2 2537..2595 CDD:197706 10/57 (18%)
I-set 2620..2703 CDD:254352 10/82 (12%)
IGc2 2633..2693 CDD:197706 7/59 (12%)
IG 2731..2800 CDD:214652 19/73 (26%)
IGc2 2731..2790 CDD:197706 16/62 (26%)
IG_like 2819..2896 CDD:214653 12/85 (14%)
IGc2 2826..2885 CDD:197706 10/67 (15%)
IG 2916..2993 CDD:214652 7/26 (27%)
IGc2 2923..2983 CDD:197706 6/19 (32%)
IG 3016..3093 CDD:214652
IGc2 3023..3083 CDD:197706
Ig_2 3112..3192 CDD:290606
IG_like 3115..3192 CDD:214653
I-set 3205..3291 CDD:254352
ig 3209..3289 CDD:278476
IG 3303..3385 CDD:214652
Ig 3313..3382 CDD:143165
IG 3404..3478 CDD:214652
IGc2 3409..3468 CDD:197706
I-set 3482..3565 CDD:254352
IGc2 3496..3555 CDD:197706
IG_like 3589..3666 CDD:214653
Ig 3600..3666 CDD:299845
I-set 3676..3755 CDD:254352
IGc2 3686..3745 CDD:197706
I-set 3764..3841 CDD:254352
Ig 3779..3834 CDD:299845
LamG 3848..4008 CDD:238058
EGF_CA <4035..4064 CDD:238011
LamG 4117..4266 CDD:238058
EGF 4291..4321 CDD:278437
EGF_CA 4328..4359 CDD:238011
LamG 4386..4545 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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