DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4793 and HABP2

DIOPT Version :9

Sequence 1:	NP_723941.2	Gene:	CG4793 / 34941	FlyBaseID:	FBgn0028514	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_004123.1	Gene:	HABP2 / 3026	HGNCID:	4798	Length:	560	Species:	Homo sapiens

Alignment Length:	316	Identity:	96/316 - (30%)
Similarity:	150/316 - (47%)	Gaps:	66/316 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 TCCPKTEILQYPVQADNQP---LP--TECG-------HVNRIGVGFTITNARDIAQKGELPWMVA 115
            :.|...:: .||.::..:|   ||  ..||       .:.||..||..|       .|:.||..:
Human   274 SACSAQDV-AYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKST-------AGKHPWQAS 330

  Fly   116 LLDSRSRLPLG---------GGSLITRDVVLTSSTKTLEVPEKYLIVRAGEWDFESITEERAHED 171
            |   :|.|||.         ||:||....|||::..| ::..::|.|..|:.|.:.  ||...:.
Human   331 L---QSSLPLTISMPQGHFCGGALIHPCWVLTAAHCT-DIKTRHLKVVLGDQDLKK--EEFHEQS 389

  Fly   172 VAIRKIVR--HTNLSVENGANNAALLFLARPLKLDHHIGL-------ICLPP---PNRNFIHNRC 224
            ..:.||.:  |.|...|...|:.|||.| :|  :|.|..|       :|||.   |:    .:.|
Human   390 FRVEKIFKYSHYNERDEIPHNDIALLKL-KP--VDGHCALESKYVKTVCLPDGSFPS----GSEC 447

  Fly   225 IVSGWGKKTALDNSYMNILKKIELPLVDRSVCQTKLQGPYGKDFILDNSLICAGG--EPGKDTCK 287
            .:||||.......|...:..|::  |:..::|.::..    .|.::|:|:||||.  :||:|||:
Human   448 HISGWGVTETGKGSRQLLDAKVK--LIANTLCNSRQL----YDHMIDDSMICAGNLQKPGQDTCQ 506

  Fly   288 GDGGAPLACPLQSDPNRYELLGIVNFGFGCGGPLPAAYTDVSQIRSWIDNCIQAEA 343
            ||.|.||.|  :.| ..|.:.|||::|..| |..|..||.|::..:||...|::|:
Human   507 GDSGGPLTC--EKD-GTYYVYGIVSWGLEC-GKRPGVYTQVTKFLNWIKATIKSES 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4793	NP_723941.2	Tryp_SPc	105..337	CDD:238113	81/254 (32%)
CG4793	NP_723941.2	Tryp_SPc	105..335	CDD:214473	79/252 (31%)
HABP2	NP_004123.1	EGF	77..106	CDD:306513
		KR	191..277	CDD:238056	0/2 (0%)
		Tryp_SPc	314..553	CDD:238113	85/268 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910