DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4793 and F11

DIOPT Version :9

Sequence 1:	NP_723941.2	Gene:	CG4793 / 34941	FlyBaseID:	FBgn0028514	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_005262878.1	Gene:	F11 / 2160	HGNCID:	3529	Length:	626	Species:	Homo sapiens

Alignment Length:	338	Identity:	98/338 - (28%)
Similarity:	148/338 - (43%)	Gaps:	54/338 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KECVQRNRCRIGTETGRPIIDFRGLNNGNQGCESGQTCCPKTEILQYPVQADNQPLPTECGHVNR 91
            |.|....||:..|.|...    ...|.||:|     .|.         ::..:...||:..| .|
Human   319 KLCTNAVRCQFFTYTPAQ----ASCNEGNRG-----KCY---------LKLSSNGSPTKILH-GR 364

  Fly    92 IGV-GFTITNAR----------------DIAQKGELPWMVAL-LDSRSRLPLGGGSLITRDVVLT 138
            .|: |:|:...:                ..:.:||.||.|.| ..|.::..|.|||:|....:||
Human   365 GGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILT 429

  Fly   139 SS--TKTLEVPEKYLIVRAGEWDFESITEERAHEDVAIRKIVRHTNLSVENGANNAALLFLARPL 201
            ::  ...:|.| |.|.|.:|..:...|.|:.:.  ..:::|:.|....:.....:.|||.|...:
Human   430 AAHCFYGVESP-KILRVYSGILNQSEIKEDTSF--FGVQEIIIHDQYKMAESGYDIALLKLETTV 491

  Fly   202 KLDHHIGLICLPPP-NRNFIHNRCIVSGWGKKTALDNSYMNILKKIELPLVDRSVCQTKLQGPYG 265
            ........||||.. :||.|:..|.|:|||.: .|.:...|.|:|.::|||....||.:.:|
Human   492 NYTDSQRPICLPSKGDRNVIYTDCWVTGWGYR-KLRDKIQNTLQKAKIPLVTNEECQKRYRG--- 552

  Fly   266 KDFILDNSLICAG-GEPGKDTCKGDGGAPLACPLQSDPNRYELLGIVNFGFGCG-GPLPAAYTDV 328
              ..:.:.:|||| .|.|||.||||.|.||:|   .....:.|:||.::|.||. ...|..||:|
Human   553 --HKITHKMICAGYREGGKDACKGDSGGPLSC---KHNEVWHLVGITSWGEGCAQRERPGVYTNV 612

  Fly   329 SQIRSWIDNCIQA 341
            .:...||....||
Human   613 VEYVDWILEKTQA 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4793	NP_723941.2	Tryp_SPc	105..337	CDD:238113	78/237 (33%)
CG4793	NP_723941.2	Tryp_SPc	105..335	CDD:214473	76/235 (32%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519
		APPLE	110..193	CDD:128519
		APPLE	200..283	CDD:128519
		APPLE	291..375	CDD:128519	18/74 (24%)
		Tryp_SPc	388..619	CDD:214473	76/242 (31%)
		Tryp_SPc	389..619	CDD:238113	76/241 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910