DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4793 and F10

DIOPT Version :9

Sequence 1:	NP_723941.2	Gene:	CG4793 / 34941	FlyBaseID:	FBgn0028514	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	344	Identity:	84/344 - (24%)
Similarity:	138/344 - (40%)	Gaps:	93/344 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TETGRPIIDF------RGLNN-----GNQGCESGQTCCPKTEILQYPVQADNQPLPTECGHVNRI 92
            ||....::||      ||.||     |.|.|:.|                       ||
Human   211 TENPFDLLDFNQTQPERGDNNLTRIVGGQECKDG-----------------------EC------ 246

  Fly    93 GVGFTITNARDIAQKGELPWMVALLDSRSRLPLGGGSLITRDVVLTSSTKTLEVPEKYLIVRAGE 157
                              ||. |||.:.......||::::...:||::....:.  |...||.|:
Human   247 ------------------PWQ-ALLINEENEGFCGGTILSEFYILTAAHCLYQA--KRFKVRVGD 290

  Fly   158 WDFESITEERAHEDV-AIRKIVRHTNLSVENGANNAALLFLARPLKLDHHIGLICLPPPNRNFIH 221
            .:.|   :|...|.| .:..:::|...:.|....:.|:|.|..|:....::...||  |.|::..
Human   291 RNTE---QEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACL--PERDWAE 350

  Fly   222 NRC------IVSGWGKKTALDNSYMNILKKIELPLVDRSVCQTKLQGPYGKDFILDNSLICAGGE 280
            :..      ||||:| :|.........||.:|:|.|||:.|:      ....||:..::.|||.:
Human   351 STLMTQKTGIVSGFG-RTHEKGRQSTRLKMLEVPYVDRNSCK------LSSSFIITQNMFCAGYD 408

  Fly   281 -PGKDTCKGDGGAPLACPLQSDPNRYELLGIVNFGFGCG--GPLPAAYTDVSQIRSWIDNCIQA- 341
             ..:|.|:||.|.|.....:   :.|.:.|||::|.||.  |.. ..||.|:....|||..::.
Human   409 TKQEDACQGDSGGPHVTRFK---DTYFVTGIVSWGEGCARKGKY-GIYTKVTAFLKWIDRSMKTR 469

  Fly   342 ---EAVHYSPQLGNVGQSP 357
               :|..::|::  :..||
Human   470 GLPKAKSHAPEV--ITSSP 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4793	NP_723941.2	Tryp_SPc	105..337	CDD:238113	65/241 (27%)
CG4793	NP_723941.2	Tryp_SPc	105..335	CDD:214473	63/239 (26%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	71/294 (24%)
		O-glycosylated at one site	476..485		1/10 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910