DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31821 and SCPEP1

DIOPT Version :9

Sequence 1:	NP_001285968.1	Gene:	CG31821 / 34938	FlyBaseID:	FBgn0051821	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_067639.1	Gene:	SCPEP1 / 59342	HGNCID:	29507	Length:	452	Species:	Homo sapiens

Alignment Length:	431	Identity:	140/431 - (32%)
Similarity:	229/431 - (53%)	Gaps:	49/431 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GEQDWGYVDVRDGAHMFYWLYYTTANVSSYTDRPLVLWLQGGPGGSSTALGNFQELGPVDTNGQP 91
            |::.|.||.||..|:||:||||.|.:..::::.|||:|||||||||||..|||:|:||:|::.:|
Human    36 GKEVWDYVTVRKDAYMFWWLYYATNSCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDSDLKP 100

  Fly    92 RDGNWVQYVNVLFIDNPVGSGFSYADNTSLLVTNNEELIDDLISFMLHFYKLHKEFKNVPLHIFS 156
            |...|:|..::||:|||||:||||.:.:.....:...:..|::..:..|:..||||:.||.:|||
Human   101 RKTTWLQAASLLFVDNPVGTGFSYVNGSGAYAKDLAMVASDMMVLLKTFFSCHKEFQTVPFYIFS 165

  Fly   157 ESYGGKMAPALAIRLAKAMSAGELAHPGTLK----SVTIGNPWISTRHISREHSKYLFVNGLIDE 217
            ||||||||..:.:.|.||:..      ||:|    .|.:|:.|||..........||:...|:::
Human   166 ESYGGKMAAGIGLELYKAIQR------GTIKCNFAGVALGDSWISPVDSVLSWGPYLYSMSLLED 224

  Fly   218 DGVALLDAQEERILSALKKHEFDKATDEYLRWYELMQQLTGEIYLYNTQTHVDPSEDRTYGYGEE 282
            .|:|.:....|::|:|:.|..:.:||:.:.:...:::|.|..:..||..|...|:.  |.....|
Human   225 KGLAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTS--TMESSLE 287

  Fly   283 F------------IRFIERNVSEALQINGTV------------YASQVMEVLSSLHGDRLKSEIN 323
            |            :|.::|:....| :||.:            :..|...|..::..|.:|..|:
Human   288 FTQSHLVCLCQRHVRHLQRDALSQL-MNGPIRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVIS 351

  Fly   324 TIPRLLNETSVKVNIYSGQLDTLVPTTATLALIKDWAWND-------KSEYLEANRTTIVIKGIL 381
            .:..|| |..:.|.:|:||||.:|.|....|.::...|.:       |.:.|.::..::.....:
Human   352 IVDELL-EAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDPKSLETSAFV 415

  Fly   382 QGYKKVGGNFGMYWINRSGHMAPSDNPVAMQYVLQSVTQYD 422
            :.||    |...|||.::|||.|||.......:::.|||.:
Human   416 KSYK----NLAFYWILKAGHMVPSDQGDMALKMMRLVTQQE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31821	NP_001285968.1	Peptidase_S10	26..417	CDD:298660	137/424 (32%)
SCPEP1	NP_067639.1	Peptidase_S10	36..446	CDD:306866	137/423 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156956
Domainoid	1	1.000	311	1.000	Domainoid score	I1318
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	1	1.000	-	-		FOG0003531
OrthoInspector	1	1.000	-	-		otm40567
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2409
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870