Protein Alignment Tep1 and c4b

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001352066.1
• Gene: c4b / 794635
• ZFINID: ZDB-GENE-100805-2
• Length: 1717
• Species: Danio rerio
• Alignment Length: 1653
• Identity: 369/1653 - (22%)
• Similarity: 640/1653 - (38%)
• Gaps: 393/1653 - (23%)

  Fly     1 MLWLILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGP----SL 61
            :|:|:|   .:.|.:..|:|..:.:.||..........:|:         :|..:|.|.    .|
Zfish     8 LLYLLL---CMSCAVQGNSNQRFLITAPSVFHVGVKEPIVI---------QVGEALVGKPVSCQL 60

  Fly    62 NSRKYVDVQSMSSKSVRFDIPKLTEGDYE---LKVMG---------SGGIEFQN----------S 104
            .:...|.:.:..:|::.      .:|.:|   |::..         :|...:.|          .
Zfish    61 ETETRVPMSAKETKTIH------QKGKFETVNLEIFANTVSNLKSINGEPPYLNLACEVDGQRQQ 119

  Fly   105 TKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDI 169
            |::..:....:::||:|:..|.|..|::||:..||.:.||. ::..:.:.|.:.|.|.:|..| .
Zfish   120 TRVLVSKHNGYIFIQTDQPIYNPTQKVRFRIFTLDHSMRPK-LEMYVYVSIYNADGNKVKKSK-Y 182

  Fly   170 KPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLV----VDKYVVPKFEVVVLTAKN-VAA 229
            :...|:.|.:.::.|....|.|.:||..:|:  |.|..|    |.|:|:|.|.|.|.:.|. :.|
Zfish   183 RVLDGILSKDYKIPDVSKPGVWKITAHYEDD--VDNAAVREFKVQKFVLPSFGVSVHSEKAFLQA 245

  Fly   230 SAGYIRATIKARYTFKKPVKG--HVVATIEGSSTEQSLPI-------------DGEVNVEFPIS- 278
            :|..:..||:|.|::.|.:.|  |....|:...:|....|             :|...:...||
Zfish   246 NAKTLTFTIQASYSYGKTIDGGFHCRFGIKKGKSENDPEIEFIKGLEKTGSVKEGLAKITVNISD 310

  Fly   279 ------------ATAKRLLKITAIVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSE 331
                        ||.:....|:|.||:.|:........::.|...|:.::.......|.|....:
Zfish   311 ITQKLDTALEELATTQTQFYISATVTDILSGEVQESETFLPVVLSRYNVDLSRTRLFYTPAFPLQ 375

  Fly   332 FKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETCQSCLVTSTFDTAE 396
            ....||:.:|||.  ....|..:|...:.......:.:..||.....|.....|.||.:|.|.|:
Zfish   376 AVVTVRHPNGSPA--EGVQVKLDVSNSKEKSTIVTTNKEGIAFYSFNLDGKPPSVLVQATVDNAK 438

  Fly   397 NIERYIYKLNKP--LMIAINTKKPQLRKLLKINII-----SDTYLPYFILT--------VVARGN 446
            :| |.::.:...  |.:::..|.....:.|:::..     .|..:.|.|::        .||.|:
Zfish   439 SI-RAVHPMKSTSFLYMSVTNKVLSSGQFLEVSFYPKGNPEDGQIYYMIVSRGMLRSTGSVASGS 502

  Fly   447 IVLSLFQEMKEKKKSQEI--EFEPTFALVPQATIFVHYIIDGVLMSDEKTVDIERDFENTIEI-L 508
                      |.|||.:|  ...|:|.|     |..:||.:|.:::|...||:|...:...|: |
Zfish   503 ----------EVKKSIQIHPNMTPSFRL-----IAFYYIKEGDIIADSVWVDVEDTCDGEFEVKL 552

  Fly   509 TTN------EALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTDL-- 565
            ..|      |.....|:.:.|....::.|.|..||:::..|.:.|.|.:..:..::.:|  ||
Zfish   553 HHNYGNHNYEPESTAELDIDVGQQKNAKVALQVVDKAIYALGAQNKLTQKQVFASMKSY--DLGC 615

  Fly   566 ---------VILTNANI----------NIYRSSGGCYT--------------------------- 584
                     .:..:|.:          :..|....|.:
Zfish   616 SYGGGENTAAVFNDAGLAFISHSTTIRSAMRKGFSCESGFRRNKREIDVQAEMARKEAAFKKTEL 680

  Fly   585 ----NPGYT---------------------NCTGSLIGRTMF-------KNEPTKNSGPVPIVGS 617
                ..|:|                     :|..:......|       |......:|....:.|
Zfish   681 QKCCRHGFTLIPMKFTCDERAKRVSKTESKDCVNAFRECCEFATKLRDKKRREDMRTGHGRTINS 745

  Fly   618 TRAQA----SLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVT 678
            ...:.    .:..:|..||.::.|..| ||  .|:...:..:|.::|:|.|...||||..|..|.
Zfish   746 NEVEEFFDFEIQNIRHYFPPSFEFKQI-DV--KGKVRHRIHLPHSITTWEIQALSLSPSHGFCVA 807

  Fly   679 RNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNV 743
             .|..:..|:|.||:..|||||||.|.::|..::|||..|:::..|.|...||.......|:.:.
Zfish   808 -EPVDLTAFKPVFISLRLPYSVKRYEQLSIVAVIFNYGKMEMELVVRMRQVDGLCSPGSATSSSS 871

  Fly   744 SQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQKYV 808
            .::.......:|:..||..      |:: .::.:|........|...|.:.:||.|:.:||:...
Zfish   872 VRFSLKPASSQTVTFPAVP------MVK-GEIPITIAIYDIEEKIEVDAIQKILLVKNEGVEMRE 929

  Fly   809 NKAVLINV-----QRLNRRSLAPPEKTIIIEKADNVIEGSET-----VEFEVCGTSQAPQL---E 860
            ....|||:     .||:.....|          :|.:..::.     :|.|:...|.|..|   .
Zfish   930 ELTYLINLDGRSDHRLSINGFFP----------NNTVPETDVNLFVKLEEEIFAQSTAVPLLSSS 984

  Fly   861 HLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIE----NKAKRYVETGYQIELNYKRN 921
            .:::|:..|.|||||.|....|:.|::.||. |:::..|:|    :||..::|..|:..|.:|:.
Zfish   985 KVENLIQAPKGCGEQTMIFMSPTALSIRYLD-KSQRWLELEAGSRDKALDFIEQAYERILTFKKT 1048

  Fly   922 DGSFSAWGQHDALGSTWLTAYVIRSFHQAA-KYID-----------IDKNVLVAGLDFLVSRQST 974
            |||:.||.|...  ||||||.|::.....| :.|:           |.:..:...:.:|:..|.:
Zfish  1049 DGSYGAWIQTPT--STWLTALVVKVLSLVAERQIETRQQHGTTERMISQEDIRQAVTYLIKTQRS 1111

  Fly   975 DGKFKELGMVIHNSHGSPL-------ALTSFVLLTFFENEEYMPK----YKHVIDRAVEFVVTEV 1028
            ||.|.:...|.|......:       :||:|:.:....:..::.:    ....|.||..|::..|
Zfish  1112 DGSFTDAHPVYHREMQGGIGGVEQDASLTAFITIALCRSMPFLDQEATAVSQSIARATNFLLKRV 1176

  Fly  1029 HQSNEPYDLAIAALALS--LARNRNAYKVLDKLDKLATRRGDHKWWTGSD------KCKSS---- 1081
            .....||.|||.|..||  |.....|.....||..|....||...|...|      :.||:
Zfish  1177 DNLKRPYALAITAYCLSTCLTERTQALSAWKKLQSLGKPEGDCLVWQDDDDVRLVNEAKSNRVPH 1241

  Fly  1082 ----EVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHAS 1142
                :||||:|.||..|.|:.....:..|.:|.|:.|..|||.|:|||:|.:.||::|.| |...
Zfish  1242 RVALKVETTAYALLTALAHSDLKTAQSAVCFLSSQENYEGGFKSTQDTIVALEALSEYAL-SLPE 1305

  Fly  1143 TEAIDI----------EFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLT 1197
            |....|          |...:|.:|      .||:.:.:..:|......|.|..||:.:.:|...
Zfish  1306 TPITTINAQFTVTGRSEMEKMNLEK------SENKVEAELKRLVGQEINVNLSGKGKAKMKVAKA 1364

  Fly  1198 Y----------------------RYNVATKE-----------------------------ARPSF 1211
            |                      .|....:|                             ||...
Zfish  1365 YYTLKEDGNCADLSINVTVVGKVEYTSVVQEDYNYYEDYGQAEETNEEEDLPRSAIEWFDARSRQ 1429

  Fly  1212 KLTTTVKKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAI-SDVK 1275
            |..|:  |:.|..::..:|.::|     :..|.:.||:..:.|.||:          ||| :|::
Zfish  1430 KRETS--KNTKEDVVYTVCVSHT-----QGRKLSGMAIADITLLSGF----------EAINTDLE 1477

  Fly  1276 RVE-------TKNEDT--EVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSA 1331
            :::       :..|.|  .|.:||.::..|: .|:...|..:..:..::|:....||||..:|..
Zfish  1478 KLKGLVDKYISHYEVTRGRVLLYFNEIDGGE-ACIAFGAEQSVPIGLVQPAPALFYDYYEPDRRC 1541

  Fly  1332 TEFYHVD------TSLC--DICHGNECG 1351
            :..|...      :.||  |:|...|.|
Zfish  1542 SVLYSAPKRSKMVSVLCSDDVCQCAERG 1569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	25/84 (30%)
		A2M_N_2	411..542	CDD:285005	34/152 (22%)
		A2M	634..726	CDD:278630	34/91 (37%)
		A2M_2	859..1135	CDD:239227	95/321 (30%)
		A2M_comp	910..1135	CDD:284982	76/263 (29%)
		A2M_recep	1245..1335	CDD:284981	23/99 (23%)
c4b	NP_001352066.1	A2M_N	130..224	CDD:307790	28/97 (29%)
		A2M_N_2	452..593	CDD:311575	35/155 (23%)
		ANATO	667..735	CDD:237984	5/67 (7%)
		A2M	772..854	CDD:306673	33/85 (39%)
		complement_C3_C4_C5	982..1299	CDD:239226	94/319 (29%)
		A2M_recep	1456..1545	CDD:311553	23/99 (23%)
		NTR_complement_C4	1563..1715	CDD:239639	3/7 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584120
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.810