Protein Alignment Tep1 and C4B

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001002029.3
• Gene: C4B / 721
• HGNCID: 1324
• Length: 1744
• Species: Homo sapiens
• Alignment Length: 1675
• Identity: 373/1675 - (22%)
• Similarity: 629/1675 - (37%)
• Gaps: 414/1675 - (24%)

  Fly     1 MLW-LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEV--SVSLTGPSLN 62
            :|| ||.:|:..   .||.......:.:|..:......:|.|.:.:..|...|  ||.|..||.|
Human     3 LLWGLIWASSFF---TLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRN 64

  Fly    63 SRKYVDVQSMSSKSVRFDIPKLTEGDY-------ELKVMGSGGI-------EFQ----------- 102
            :         ...|.:.|....:|.|:       .||...|.|:       |.|
Human    65 N---------VPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDS 120

  Fly   103 -------NSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQ 160
                   ....|.|:.....|::|:|:..|.||.::::||..||:..||:.....:.:|...|
Human   121 LSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHG-- 183

  Fly   161 NLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLT 223
             |....|::.....::..:..:.|....|.|.::|...|  |...:....|.|||:|.|||.:..
Human   184 -LRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITP 247

  Fly   224 AK----NVAASAGYIRATIKARYTFKKPVKGHVVATI-------EGSST------EQSLPIDGEV 271
            .|    .|......::..|:|||.:.|||:|  ||.:       :|..|      .|:..::|:.
Human   248 GKPYILTVPGHLDEMQLDIQARYIYGKPVQG--VAYVRFGLLDEDGKKTFFRGLESQTKLVNGQS 310

  Fly   272 NVEFPISATAKRLLKITAIVTEELTDIKHNGTAYVT---VHQHRHKLED---LFW---------- 320
            ::....:.....|.|:...:| :|..::    .||.   :.....::|:   ..|
Human   311 HISLSKAEFQDALEKLNMGIT-DLQGLR----LYVAAAIIESPGGEMEEAELTSWYFVSSPFSLD 370

  Fly   321 ----PTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVL-------CCQVSKNFSASLQNSIAT 374
                ..|..||.....:.:||.:.|||.......|:..|.       ...:.:|...|.|.||.
Human   371 LSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDIQQNTDGSGQVSIP- 434

  Fly   375 EHIMLPETCQSC-LVTSTFDTAENIERY-----------IYKLNKPLMIAINTKKPQLRKLLKIN 427
              |::|:|.... |..|.......|.|.           ...:.:|     :::.|::...|.:|
Human   435 --IIIPQTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERP-----DSRPPRVGDTLNLN 492

  Fly   428 I----ISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDGVL 488
            :    ...|:..|:.: :::||.||   |...:.|:....:.......|.|.......|......
Human   493 LRAVGSGATFSHYYYM-ILSRGQIV---FMNREPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHP 553

  Fly   489 MSDEKTVDIERD-FENTIEILTTNEALPR--DEVSLKVKTNPHSFVGLLGVDQSVLLL--RSGND 548
            :::...||::.. .|..:|:........|  :.|.|.::|:..:.|.|..:|.::...  :|...
Human   554 VANSLRVDVQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKP 618

  Fly   549 LNRDLILNNLATY---------STDLVILTNA-----------------------------NINI 575
            ||...:...:.:|         .:.|.:...|                             |:|.
Human   619 LNMGKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNF 683

  Fly   576 YRSSG---GCYTNP--------GYT------------------NCTGSLIGRTMFKNEPTKNSGP 611
            .::..   |.|.:|        |.|                  :|....:....|.....|.|..
Human   684 QKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCCQFAESLRKKSRD 748

  Fly   612 VPIVGSTRAQASLP----------PVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITG 666
            ....|..||...|.          |||..|||.||:...|   .:...|:...:||:||:|.|.|
Human   749 KGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVET---VDRFQILTLWLPDSLTTWEIHG 810

  Fly   667 FSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDG 731
            .|||...||.|. .|.::|||:.|.:...||.||:|.|.:.:..:::|||..::...|.:...:|
Human   811 LSLSKTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEG 874

  Fly   732 QYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY---AGDRL 793
            ..            ...|....:.:.:||.:.|.::|.:.|......:||:.|...:   .||.:
Human   875 LC------------LAGGGGLAQQVLVPAGSARPVAFSVVPTAATAVSLKVVARGSFEFPVGDAV 927

  Fly   794 HQILKVEADGVQKYVNKAVLINVQRLN-----RRSLAPPEKT--IIIEKAD--NVIEGSETVEFE 849
            .::|::|.:|.   :::..|  |..||     .|:|..|..:  .:|...|  :.:..:.:...:
Human   928 SKVLQIEKEGA---IHREEL--VYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLD 987

  Fly   850 VCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ----DQEIENKAKRYVET 910
            ..|:..|.....:..|:.||.|||||.|....|::.|..||. |..|    ..|.::.|...::.
Human   988 TLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLD-KTEQWSTLPPETKDHAVDLIQK 1051

  Fly   911 GYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTD 975
            ||.....:::.|||::||....:  ||||||:|::....|.:.:......|....::|:|:|..|
Human  1052 GYMRIQQFRKADGSYAAWLSRGS--STWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQAD 1114

  Fly   976 GKFKELGMVIHNS-------HGSPLALTSFVL------LTFFENEEYMPKYKHV---IDRAVEFV 1024
            |.|::|..|||.|       :...:|||:||.      |..|::|...|..:.|   |.:|..|:
Human  1115 GSFQDLSPVIHRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKASSFL 1179

  Fly  1025 -------VTEVHQSNEPYDLAIAALALSLARNRNAYKVL--DKLDKLATRRGDHKWW---TGSDK 1077
                   :...|.:      ||.|.||:|.:.....:.:  :.|..:|...||:.:|   |||..
Human  1180 GEKASAGLLGAHAA------AITAYALTLTKAPADLRGVAHNNLMAMAQETGDNLYWGSVTGSQS 1238

  Fly  1078 CKSSE------------------VETTSYVLLALLEH----NISDEPKPIVDWLISKRNSNGGFV 1120
            ...|.                  :|||:|.||.||.|    .::|:   ...||..:.:..|||.
Human  1239 NAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEMADQ---AAAWLTRQGSFQGGFR 1300

  Fly  1121 SSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLL 1185
            |:||||:.:.||:.|.:.||.:.|.      .||..   :..|..|.||  :|.|..|..:::.|
Human  1301 STQDTVIALDALSAYWIASHTTEER------GLNVT---LSSTGRNGFK--SHALQLNNRQIRGL 1354

  Fly  1186 AK---------------GQGRAQVQLTYRYNVA----------------------TKEARPSF-- 1211
            .:               |..:..:::...|||.                      |.||...:
Human  1355 EEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYED 1419

  Fly  1212 ---------------------------------KLTTTVKKSHKGRLILGICGTYTPIAASERNK 1243
                                             :....|.:..:.|:...:|     |..:.:..
Human  1420 YEYDELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVC-----IWRNGKVG 1479

  Fly  1244 TTNMALMQVQLPSGY---VCDIEPFADIEAISD--VKRVETKNEDTEVHIYFEKLSPGDRKCLTL 1303
            .:.||:..|.|.||:   ..|:|   .:.::||  |...||  |...|.:||:.: |..|:|:..
Human  1480 LSGMAIADVTLLSGFHALRADLE---KLTSLSDRYVSHFET--EGPHVLLYFDSV-PTSRECVGF 1538

  Fly  1304 EAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNEC 1350
            ||:....|..::|:...|||||..||..:.||...:.   |..:|....|
Human  1539 EAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVC 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	296/1307 (23%)
		A2M_2	859..1135	CDD:239227	95/329 (29%)
		A2M_recep	1243..1336	CDD:462226	32/97 (33%)
C4B	NP_001002029.3	YfaS	<138..1336	CDD:441940	289/1261 (23%)
		ANATO	686..750	CDD:237984	9/63 (14%)
		A2M	781..869	CDD:459711	32/91 (35%)
		TED_complement	982..1315	CDD:462227	97/344 (28%)
		A2M_recep	1481..1570	CDD:462226	31/94 (33%)
		NTR_complement_C4	1588..1742	CDD:239639	1/1 (100%)