DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and C4A

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_009224.2	Gene:	C4A / 720	HGNCID:	1323	Length:	1744	Species:	Homo sapiens

Alignment Length:	1683	Identity:	373/1683 - (22%)
Similarity:	626/1683 - (37%)	Gaps:	430/1683 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLW-LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEV--SVSLTGPSLN 62
            :|| ||.:|:..   .||.......:.:|..:......:|.|.:.:..|...|  ||.|..||.|
Human     3 LLWGLIWASSFF---TLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRN 64

  Fly    63 SRKYVDVQSMSSKSVRFDIPKLTEGDY-------ELKVMGSGGI-------EFQ----------- 102
            :         ...|.:.|....:|.|:       .||...|.|:       |.|
Human    65 N---------VPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDS 120

  Fly   103 -------NSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQ 160
                   ....|.|:.....|::|:|:..|.||.::::||..||:..||:.....:.:|...|
Human   121 LSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHG-- 183

  Fly   161 NLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLT 223
             |....|::.....::..:..:.|....|.|.::|...|  |...:....|.|||:|.|||.:..
Human   184 -LRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITP 247

  Fly   224 AK----NVAASAGYIRATIKARYTFKKPVKGHVVATI-------EGSST------EQSLPIDGEV 271
            .|    .|......::..|:|||.:.|||:|  ||.:       :|..|      .|:..::|:.
Human   248 GKPYILTVPGHLDEMQLDIQARYIYGKPVQG--VAYVRFGLLDEDGKKTFFRGLESQTKLVNGQS 310

  Fly   272 NVEFPISATAKRLLKITAIVTEELTDIKHNGTAYVT---VHQHRHKLED---LFW---------- 320
            ::....:.....|.|:...:| :|..::    .||.   :.....::|:   ..|
Human   311 HISLSKAEFQDALEKLNMGIT-DLQGLR----LYVAAAIIESPGGEMEEAELTSWYFVSSPFSLD 370

  Fly   321 ----PTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVL-------CCQVSKNFSASLQNSIAT 374
                ..|..||.....:.:||.:.|||.......|:..|.       ...:.:|...|.|.||.
Human   371 LSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDIQQNTDGSGQVSIP- 434

  Fly   375 EHIMLPETCQSC-LVTSTFDTAENIERY-----------IYKLNKPLMIAINTKKPQLRKLLKIN 427
              |::|:|.... |..|.......|.|.           ...:.:|     :::.|::...|.:|
Human   435 --IIIPQTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERP-----DSRPPRVGDTLNLN 492

  Fly   428 I----ISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDGVL 488
            :    ...|:..|:.: :::||.||   |...:.|:....:.......|.|.......|......
Human   493 LRAVGSGATFSHYYYM-ILSRGQIV---FMNREPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHP 553

  Fly   489 MSDEKTVDIERD-FENTIEILTTNEALPR--DEVSLKVKTNPHSFVGLLGVDQSVLLL--RSGND 548
            :::...||::.. .|..:|:........|  :.|.|.::|:..:.|.|..:|.::...  :|...
Human   554 VANSLRVDVQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKP 618

  Fly   549 LNRDLILNNLATY---------STDLVILTNA-----------------------------NINI 575
            ||...:...:.:|         .:.|.:...|                             |:|.
Human   619 LNMGKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNF 683

  Fly   576 YRSSG---GCYTNP--------GYT------------------NCTGSLIGRTMFKNEPTKNSGP 611
            .::..   |.|.:|        |.|                  :|....:....|.....|.|..
Human   684 QKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCCQFAESLRKKSRD 748

  Fly   612 VPIVGSTRAQASLP----------PVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITG 666
            ....|..||...|.          |||..|||.||:...|   .:...|:...:||:||:|.|.|
Human   749 KGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVET---VDRFQILTLWLPDSLTTWEIHG 810

  Fly   667 FSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDG 731
            .|||...||.|. .|.::|||:.|.:...||.||:|.|.:.:..:::|||..::...|.:...:|
Human   811 LSLSKTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEG 874

  Fly   732 QYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY---AGDRL 793
            ..            ...|....:.:.:||.:.|.::|.:.|......:||:.|...:   .||.:
Human   875 LC------------LAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFEFPVGDAV 927

  Fly   794 HQILKVEADGVQKYVNKAVLINVQRLN-----RRSLAPPEKT--IIIEKAD--NVIEGSETVEFE 849
            .::|::|.:|.   :::..|  |..||     .|:|..|..:  .:|...|  :.:..:.:...:
Human   928 SKVLQIEKEGA---IHREEL--VYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLD 987

  Fly   850 VCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ----DQEIENKAKRYVET 910
            ..|:..|.....:..|:.||.|||||.|....|::.|..||. |..|    ..|.::.|...::.
Human   988 TLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLD-KTEQWSTLPPETKDHAVDLIQK 1051

  Fly   911 GYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTD 975
            ||.....:::.|||::||...|:  ||||||:|::....|.:.:......|....::|:|:|..|
Human  1052 GYMRIQQFRKADGSYAAWLSRDS--STWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQAD 1114

  Fly   976 GKFKELGMVIHNS-------HGSPLALTSFVL------LTFFENEEYMPKYKHV---IDRAVEFV 1024
            |.|::...|:..|       :...:|||:||.      |..|::|...|..:.|   |.:|..|:
Human  1115 GSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFL 1179

  Fly  1025 -------VTEVHQSNEPYDLAIAALALSL----------ARNRNAYKVLDKLDKLATRRGDHKWW 1072
                   :...|.:      ||.|.||:|          |.|        .|..:|...||:.:|
Human  1180 GEKASAGLLGAHAA------AITAYALTLTKAPVDLLGVAHN--------NLMAMAQETGDNLYW 1230

  Fly  1073 ---TGSDKCKSSE------------------VETTSYVLLALLEH----NISDEPKPIVDWLISK 1112
               |||.....|.                  :|||:|.||.||.|    .::|:...   ||..:
Human  1231 GSVTGSQSNAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEMADQASA---WLTRQ 1292

  Fly  1113 RNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPE 1177
            .:..|||.|:||||:.:.||:.|.:.||.:.|.      .||..   :..|..|.||  :|.|..
Human  1293 GSFQGGFRSTQDTVIALDALSAYWIASHTTEER------GLNVT---LSSTGRNGFK--SHALQL 1346

  Fly  1178 NTNEVKLLAK---------------GQGRAQVQLTYRYNVA----------------------TK 1205
            |..:::.|.:               |..:..:::...|||.                      |.
Human  1347 NNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTM 1411

  Fly  1206 EARPSF-----------------------------------KLTTTVKKSHKGRLILGICGTYTP 1235
            ||...:                                   :....|.:..:.|:...:|
Human  1412 EANEDYEDYEYDELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVC----- 1471

  Fly  1236 IAASERNKTTNMALMQVQLPSGY---VCDIEPFADIEAISD--VKRVETKNEDTEVHIYFEKLSP 1295
            |..:.:...:.||:..|.|.||:   ..|:|   .:.::||  |...||  |...|.:||:.: |
Human  1472 IWRNGKVGLSGMAIADVTLLSGFHALRADLE---KLTSLSDRYVSHFET--EGPHVLLYFDSV-P 1530

  Fly  1296 GDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNEC 1350
            ..|:|:..||:....|..::|:...|||||..||..:.||...:.   |..:|....|
Human  1531 TSRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVC 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	21/86 (24%)
		A2M_N_2	411..542	CDD:285005	25/137 (18%)
		A2M	634..726	CDD:278630	32/91 (35%)
		A2M_2	859..1135	CDD:239227	95/337 (28%)
		A2M_comp	910..1135	CDD:284982	78/282 (28%)
		A2M_recep	1245..1335	CDD:284981	31/94 (33%)
C4A	NP_009224.2	A2M_N	141..233	CDD:280081	22/94 (23%)
		A2M_N	141..233		22/94 (23%)
		A2M_N_2	478..610	CDD:285005	26/140 (19%)
		A2M_N_2	478..610		26/140 (19%)
		ANATO	686..750	CDD:237984	9/63 (14%)
		ANATO	686..750		9/63 (14%)
		A2M	782..869	CDD:278630	32/90 (36%)
		A2M	782..869		32/90 (36%)
		complement_C3_C4_C5	996..1315	CDD:239226	95/338 (28%)
		complement_C3_C4_C5	996..1315		95/338 (28%)
		A2M_comp	1051..1317	CDD:284982	79/284 (28%)
		A2M_comp	1051..1317		79/284 (28%)
		A2M_recep	1481..1570	CDD:284981	31/94 (33%)
		A2M_recep	1481..1570		31/94 (33%)
		NTR_complement_C4	1588..1742	CDD:239639	1/1 (100%)
		NTR_complement_C4	1588..1742		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149974
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810