DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and C3

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_000055.2	Gene:	C3 / 718	HGNCID:	1318	Length:	1663	Species:	Homo sapiens

Alignment Length:	1582	Identity:	368/1582 - (23%)
Similarity:	654/1582 - (41%)	Gaps:	336/1582 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDVQSMSSK----- 75
            |:..:.:||::.|..||..|...:|:..|:.  ..:|.|::|......:|.|    :||:
Human    19 LALGSPMYSIITPNILRLESEETMVLEAHDA--QGDVPVTVTVHDFPGKKLV----LSSEKTVLT 77

  Fly    76 -------SVRFDIPKLTEGDYE------LKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKP 127
                   :|.|.||...|...|      :.|..:.|.:......| .:....:|:||:||..|.|
Human    78 PATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVL-VSLQSGYLFIQTDKTIYTP 141

  Fly   128 GDKIQFRVLFLDKNTRPAVIDKPIKIEIRDG---DQNLIKSWKDIKPAKGVYSGELQLS-DRPVL 188
            |..:.:|:..::....|......:.||..:|   .|:.:.|...:        |.|.|| |.|.|
Human   142 GSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQL--------GVLPLSWDIPEL 198

  Fly   189 ---GNWTVTATVQDEGK--VTNVLVVDKYVVPKFEVVVLTAKN---VAASAGYIRATIKARYTFK 245
               |.|.:.|..::..:  .:....|.:||:|.|||:|...:.   :....| :..||.||:.:.
Human   199 VNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKG-LEVTITARFLYG 262

  Fly   246 KPVKG--HVVATIEGSSTEQSLPI----------DGEVNVEFPISATAKRLLKITAIVTEEL--- 295
            |.|:|  .|:..|:......|||.          .|||.:...:.....:..:...:|.:.|
Human   263 KKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVS 327

  Fly   296 -TDIKHNGTAYVTVHQ-------HRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVM------- 345
             |.|.|:|:..|...:       ..:::.....|.:::||:..:....|.|.||||..
Human   328 ATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQ 392

  Fly   346 --DSSKMVNFNVLCCQVSKNFSAS---LQNSIATEHIMLPETCQSCLVTST-----FDTAENIER 400
              |:.:.:.......::|.|...|   |..::.|:...|.|..|:   |.|     :.|..|...
Human   393 GEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQA---TRTMQALPYSTVGNSNN 454

  Fly   401 YIYKLNKPLMIAINTKKPQLRK--------LLKINIISDTYLPYFILTVVARGNIVLSLFQEMKE 457
            |::         ::..:.:||.        ||:::...:..:.|:...::.:|.: |...::::|
Human   455 YLH---------LSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRL-LKAGRQVRE 509

  Fly   458 KKK-------SQEIEFEPTFALVPQATIFVHYIIDGV-----LMSDEKTVDIERDFENTIEILT- 509
            ..:       |...:|.|:|.||      .:|.:.|.     :::|...||::.....::.:.:
Human   510 PGQDLVVLPLSITTDFIPSFRLV------AYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSG 568

  Fly   510 ---TNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTDLVILTNA 571
               ..:.:|..:::||::.:..:.|.|:.||:.|.:|...|.|.:..|.:          ::..|
Human   569 QSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWD----------VVEKA 623

  Fly   572 NINIYRSSG----GCYTNPG--YTNCTG------------------------------------- 593
            :|.....||    |.:::.|  :|:.:|
Human   624 DIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPK 688

  Fly   594 -----------------SLIGRTMFKN-----------------EPTKNSGPVPIVGSTRAQASL 624
                             |...||.|.:                 |..:.......:|..|:....
Human   689 ELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDE 753

  Fly   625 PPV-------RKLFPETWLFSNITDV---GANG--EYIIKETVPDTLTSWVITGFSLSPQSGLAV 677
            ..:       |..|||:||: |:.|:   ..||  ..::...:.|::|:|.|...|:|.:.|:.|
Human   754 DIIAEENIVSRSEFPESWLW-NVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICV 817

  Fly   678 TRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNY-LGMDVKAKV-LMDNSDGQYEFIETTN 740
            . :|..:.|.|.|||...|||||.|.|.:.|..:::|| ...::|.:| |:.|.  .:..:.||.
Human   818 A-DPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNP--AFCSLATTK 879

  Fly   741 KNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITA--ISKYAGDRLHQILKVEADG 803
            :         |.::|:.||..:...:.::|.|.|.||..:::.|  ...:..|.:.:.|||..:|
Human   880 R---------RHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEG 935

  Fly   804 VQKYVNKAVLINV---QRLNRRSL----APPEKTIIIEKADNV----------IEGSETVEFEVC 851
            ::  :||.|.:..   :||.|..:    .||     .:.:|.|          ::|:...:.
Human   936 IR--MNKTVAVRTLDPERLGREGVQKEDIPP-----ADLSDQVPDTESETRILLQGTPVAQM--- 990

  Fly   852 GTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQ---EIENKAKRYVETGYQ 913
             |..|...|.|..|:..|.|||||||....|:::|:.||....:.::   |....|...::.||.
Human   991 -TEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYT 1054

  Fly   914 IELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLV-SRQSTDGK 977
            .:|.:::...:|:|:.:.  ..||||||||::.|..|...|.||..||...:.:|: .:|..||.
Human  1055 QQLAFRQPSSAFAAFVKR--APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGV 1117

  Fly   978 FKELGMVIH--------NSHGSPLALTSFVLLTFFEN----EEYMPKYKHVIDRAVEFVVTEVHQ 1030
            |:|...|||        |::...:|||:|||::..|.    ||.:......|.:|.:|:......
Human  1118 FQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMN 1182

  Fly  1031 SNEPYDLAIAALALS-LARNRNAYKVLDKLDKLATRRGDHKWWTGSDKCKSSEVETTSYVLLALL 1094
            ....|.:|||..||: :.|.:...     |:|..|...|...|....| :...||.|||.|||||
Human  1183 LQRSYTVAIAGYALAQMGRLKGPL-----LNKFLTTAKDKNRWEDPGK-QLYNVEATSYALLALL 1241

  Fly  1095 EHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEA-IDIEFWHLNEDKK 1158
            :....|...|:|.||..:|...||:.|:|.|.:...||.:|:..:....|. :|:.....:...|
Human  1242 QLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSK 1306

  Fly  1159 --HVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARP--SFKLTTTVK- 1218
              | |:..|:...:::.:..||.. ..:.|:|:|:..:.:...|:...|:...  .|.|..|:|
Human  1307 ITH-RIHWESASLLRSEETKENEG-FTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKP 1369

  Fly  1219 --------KSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISD-V 1274
                    :..|..:||.||..|      ..::...|:::.:.:.:|:..|.:   |::.::: |
Human  1370 APETEKRPQDAKNTMILEICTRY------RGDQDATMSILDISMMTGFAPDTD---DLKQLANGV 1425

  Fly  1275 KRVETKNE--------DTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSA 1331
            .|..:|.|        :|.: ||.:|:|..:..||..:......|..::|..|::|.||..|.|.
Human  1426 DRYISKYELDKAFSDRNTLI-IYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESC 1489

  Fly  1332 TEFYH---VDTSLCDICHGNEC 1350
            |.|||   .|..|..:|....|
Human  1490 TRFYHPEKEDGKLNKLCRDELC 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	25/91 (27%)
		A2M_N_2	411..542	CDD:285005	27/154 (18%)
		A2M	634..726	CDD:278630	32/98 (33%)
		A2M_2	859..1135	CDD:239227	95/292 (33%)
		A2M_comp	910..1135	CDD:284982	78/238 (33%)
		A2M_recep	1245..1335	CDD:284981	24/98 (24%)
C3	NP_000055.2	A2M_N	129..224	CDD:280081	25/102 (25%)
		A2M_N_2	458..604	CDD:285005	27/152 (18%)
		ANATO	678..747	CDD:237984	6/68 (9%)
		A2M	770..866	CDD:278630	32/97 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..973		5/23 (22%)
		complement_C3_C4_C5	996..1282	CDD:239226	95/293 (32%)
		A2M_comp	1051..1282	CDD:284982	78/238 (33%)
		A2M_recep	1398..1493	CDD:284981	24/98 (24%)
		NTR_complement_C3	1513..1661	CDD:239638
		Interaction with CFP/properdin. /evidence=ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149986
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.800