DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep1 and a2m

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:XP_031761241.1 Gene:a2m / 619586 XenbaseID:XB-GENE-481725 Length:1457 Species:Xenopus tropicalis


Alignment Length:1537 Identity:396/1537 - (25%)
Similarity:671/1537 - (43%) Gaps:268/1537 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LWLILSSTILHCVLLSNANG--------LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTG 58
            :|   |..:..|:||:...|        .|.:|.|..|...|.....:.:.:...:..|:::: |
 Frog     1 MW---SCALTLCLLLTAFPGGDPAPPDPKYMLLVPTVLHGGSEEKFCLLLSHLNESVVVTLTM-G 61

  Fly    59 PSLNSRKYVDVQSMSSKS---VRFDIPKL--TEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYI 118
            ....:...::.|.|..:.   |.|..|||  .|..|...::....:.|.:...:...|..|.:::
 Frog    62 LERQNETLLEKQVMEKEDDSCVTFMTPKLDAPEVAYLTLLVDGDSLHFTSRRSVLIKPVQNLVFV 126

  Fly   119 QSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLS 183
            |:||..||||.|:|||::.||:|..| |.:|...:.|.|...|.|..|.:::..||:.....|||
 Frog   127 QTDKPIYKPGQKVQFRIVSLDENFYP-VSEKFPAVYITDPQGNRISQWLNVELKKGLTQEFFQLS 190

  Fly   184 DRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPV 248
            ..|.||.:::....:....||:...|::||:||:||.|.....:......:..|:..|||:.|||
 Frog   191 PEPTLGTYSLIVEREKGAPVTHSFSVEEYVLPKYEVQVKLPATLTILGQEVPVTVCGRYTYGKPV 255

  Fly   249 KGHVVATI---------------EGSSTE--QSLPIDG--------------EVNVEFPISATAK 282
            .|.:...:               :|...|  |...::|              ....|..|.|:||
 Frog   256 LGRINVRVCRKFSDRYNLCQGEEDGVCEEISQRADLNGCISDVVNTKVFQMRRAGYEMKIIASAK 320

  Fly   283 RLLKITAIVTEELTDIKHNG-------TAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLD 340
                    :||:.|.::..|       :...|| ..||      ..:||:.|:....:..:.:..
 Frog   321 --------ITEDGTGVELTGEGSSEIKSTLATV-SFRH------LDSHYKKGIPLYGQVFLEDAA 370

  Fly   341 GSPVMDSSKMV-------NFNVLCCQVSKNFSASLQNSIATEHIMLP--------ETCQSC---- 386
            |:|:.:.:.:|       ||.....|     ..:.:.||.|....|.        :|...|    
 Frog   371 GNPMSNETVVVYVGNDGTNFTYTTGQ-----DGTAEFSIDTSSFQLSSVRIKASYKTGDYCSGHR 430

  Fly   387 LVTSTFDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILT----------- 440
            .:|::::.......:.|..:|..:     |...:.:.|:..|:....: ::|||           
 Frog   431 WLTASYEEDTRHVNHFYSRSKSFL-----KIQPIHRTLECQIVEKVNV-HYILTPEGVGEARNAV 489

  Fly   441 ----VVARGNIV------LSLFQEMKEKKKSQEIEFEPTFAL------VPQATIFVHYIID-GVL 488
                |:|:|.||      |:|.       .:||.:....|.|      .|.|.|.|:.::: |.:
 Frog   490 FHYLVMAKGGIVENGKHTLALI-------PNQEAQGNFLFDLPVGTNVSPSAKILVYLVLESGEV 547

  Fly   489 MSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNR- 551
            ::|..|:.:.:.|||.::: .:..|.||..:..|::.|||.|...:..||:|||||:...:|:. 
 Frog   548 IADSITLKVVQCFENKVKLSFSPTEGLPGSQAHLRLVTNPTSLCAVRAVDESVLLLKPEAELSAR 612

  Fly   552 ---DLI-LNNLATYSTDLVILTNAN-----------IN-IYRSSGGCYT--NPGYTNCTGSL--- 595
               ||: |.:|:.|..|...|....           || ||      ||  ||.:...|.::   
 Frog   613 TIYDLLPLKDLSGYDHDGKFLEELRDDPCLPLEPMYINGIY------YTPSNPDWDTDTYTILKS 671

  Fly   596 IGRTMFKNEPTKNSGPVPIVGSTR------------AQASLPP-----------VRKLFPETWLF 637
            :|..:|.|...:    .|:|...|            .:.::.|           |||.||||||:
 Frog   672 LGLKVFTNTNIR----TPVVCERRWKMENELAYDSEEELAMAPMAMRYMEVIETVRKYFPETWLW 732

  Fly   638 SNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKR 702
             ::.:..|:|:..:..|||||:|:|....|..|..:|..::...|.: .|||||:...||||..|
 Frog   733 -DLVETDADGKADLAVTVPDTITTWKAGMFCTSQGAGFGLSETISLV-AFQPFFLELTLPYSAIR 795

  Fly   703 GEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFI-ETTNKNVSQY-LRGVRRKKTLWIPANTGRG 765
            ||...:...|||||...::..:.:::||   :|: :.:|.....| ::|..|....|.......|
 Frog   796 GEKFILKATVFNYLSQTIRVAISLEDSD---QFLAKPSNLQEDGYCVKGNGRVTLSWDVTLKSLG 857

  Fly   766 -ISFMIRPKKV---GLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAP 826
             ::|.:..:.:   ||...:|....:...|.:.:.:.||.:||:|...:..:|    ..:.|...
 Frog   858 EVNFTMSAETLTGEGLCENEIVDPIQGRKDTITKHILVEPEGVEKEETQNAMI----CGKGSEIT 918

  Fly   827 PEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLK 891
            .:  |.::..:.|:|||....|...|......:::|.:||.:|.|||||||..|.|.|....||.
 Frog   919 ED--IHLKLPERVVEGSARAYFSAVGDILGTAIQNLGNLVQMPYGCGEQNMVLFTPIIYISEYLN 981

  Fly   892 AKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDI 956
            ..|:...|:::|...|:.||||.:|:||..|||:||:||....|:|||||:.::||.:|..:|.|
 Frog   982 KTNQLTPEMKSKTLSYMSTGYQKQLSYKHYDGSYSAFGQQYGEGNTWLTAFTMKSFARARAHIYI 1046

  Fly   957 DKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTFFENEEYMPKYKHVI 1017
            ::.::...|.:|.:.|..:|.|..:|.:.:|:.    ...:.|.:::.:...|..  :|.....:
 Frog  1047 EEKLISDALTWLSNHQKENGCFHSVGKLFNNAMKGGVDDEVTLAAYITIALLEYP--LPVTHPTV 1109

  Fly  1018 DRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYK-VLDKLDKLATRRGDHKWW----TGSD- 1076
            ..|:..:.:.:...|..|..|:.|.|.:||...:..: :|..||:.|.::.....|    |..| 
 Frog  1110 RNALFCLESALGGKNSIYTKALMAYAFTLAGRMDIRRQLLQSLDEQAIKKDGTVHWQRPETSDDS 1174

  Fly  1077 --------KCKSSEVETTSYVLLALL-EHNISDE----PKPIVDWLISKRNSNGGFVSSQDTVVG 1128
                    :..|:|||.|||.||.|| :.::|||    ...:|.|:|.::|.:|||.|:|||||.
 Frog  1175 GHYRNPYSQAPSAEVEMTSYGLLTLLSKPDVSDEDLTLATQVVSWIIKQQNPSGGFSSTQDTVVA 1239

  Fly  1129 IMALTKYE--LQSHASTEAIDIEFWHLNEDKKHV---RVTKENEFKVQTHQLPENTNEVKLLAKG 1188
            :.||..|.  ..||.||..:     .|:.:|..|   .|...|...:|...|.|...:......|
 Frog  1240 LQALALYGSLTLSHDSTRTV-----LLSLEKTPVAKFNVEDSNRLLLQQIALKEVPGDYTATVSG 1299

  Fly  1189 QGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQ 1253
            .|...::...||||...:...:|.:..|.:.:...|..|........::...:...:|||||:::
 Frog  1300 SGCLYLKTALRYNVPHPKEDAAFTILVTTEPTACDRKSLKSFAIVANVSYIGKRANSNMALMEIK 1364

  Fly  1254 LPSGYVCDIEPFADIEAISDVKRV--------ETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHA 1310
            :|||:|         ...|.||::        .|:.:..:|::|||.||. |.:..:........
 Frog  1365 MPSGHV---------PVKSSVKKLPRLNNFIKRTEIQTNKVNVYFELLSK-DIQSFSFLVEQDIP 1419

  Fly  1311 VANLKPSWVRLYDYYATERSATEFYHVDTSLCDICHGNECGN 1352
            ::||:|:...:||||..:..|...|...      |..|:.||
 Frog  1420 ISNLQPATAIIYDYYEKDDFAVTKYSAP------CSANDGGN 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 30/84 (36%)
A2M_N_2 411..542 CDD:285005 39/159 (25%)
A2M 634..726 CDD:278630 33/91 (36%)
A2M_2 859..1135 CDD:239227 99/298 (33%)
A2M_comp 910..1135 CDD:284982 79/247 (32%)
A2M_recep 1245..1335 CDD:284981 28/97 (29%)
a2mXP_031761241.1 YfaS <89..>1059 CDD:225248 269/1024 (26%)
MG3 218..308 CDD:407663 19/89 (21%)
A2M_N_2 454..603 CDD:400170 40/161 (25%)
A2M 729..819 CDD:395153 33/91 (36%)
A2M_2 948..1246 CDD:239227 99/299 (33%)
A2M_recep 1356..1444 CDD:400149 28/97 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 75 1.000 Domainoid score I8886
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9328
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
55.010

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