DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep1 and PZP

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:XP_011519106.1 Gene:PZP / 5858 HGNCID:9750 Length:1500 Species:Homo sapiens


Alignment Length:1526 Identity:389/1526 - (25%)
Similarity:648/1526 - (42%) Gaps:278/1526 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ILH-CVLL-------SNANGL---YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNS 63
            :|| |::|       |::|..   |.||.|..|.:.:.....|.:.:...|..||.||.....|.
Human     6 LLHLCLVLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLESGRENR 70

  Fly    64 RKYVDVQSMSSKS----VRFDIPKLTEGD----YELKVMGSGGIEFQNSTKLSFAPDLNWLYIQS 120
            ..:.|:  ::.|.    |.|.:|:::...    ..:::.|... :|:....:......:.:::|:
Human    71 SLFTDL--VAEKDLFHCVSFTLPRISASSEVAFLSIQIKGPTQ-DFRKRNTVLVLNTQSLVFVQT 132

  Fly   121 DKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDR 185
            ||..||||..::|||:.:|:|.||.....|: |.:.:..:|.|..|:.:|...|:......||..
Human   133 DKPMYKPGQTVRFRVVSVDENFRPRNELIPL-IYLENPRRNRIAQWQSLKLEAGINQLSFPLSSE 196

  Fly   186 PVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKG 250
            |:.|::.|....:..|::.:...|:::|:|||||.|...|.::.....:..|:...||:.|||.|
Human   197 PIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPG 261

  Fly   251 HVVATI---------------------------EGSSTEQ----SLPIDGEVNVEFPISATAKRL 284
              :||:                           .|..|:|    .|.|   .|..|.:.      
Human   262 --LATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQI---TNTGFEMK------ 315

  Fly   285 LKITAIVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSK 349
            |::.|.:.||.||::........:.....||:.:...:|:|.|:  .|...|..:||..|...:|
Human   316 LRVEARIREEGTDLEVTANRISEITNIVSKLKFVKVDSHFRQGI--PFFAQVLLVDGKGVPIPNK 378

  Fly   350 M----VNFNVLCCQVSKNFSASLQNSIATEHIML-----------PETC-QSCLVTSTFDTAENI 398
            :    ||........:.|.....|.||.|..|.:           |..| ....|......|::.
Human   379 LFFISVNDANYYSNATTNEQGLAQFSINTTSISVNKLFVRVFTVHPNLCFHYSWVAEDHQGAQHT 443

  Fly   399 ERYIYKLN------KPLMIAI---NTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVLS---- 450
            ...::.|:      :|:...:   :|:.......|....:.:.....|...::|:|.||.|    
Human   444 ANRVFSLSGSYIHLEPVAGTLPCGHTETITAHYTLNRQAMGELSELSFHYLIMAKGVIVRSGTHT 508

  Fly   451 LFQEMKEKKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEA 513
            |..|..:.|.|..:.|.....:.|.|.:|:..|: ||.::.|.:..:||....|.::: .:..::
Human   509 LPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSFSPAQS 573

  Fly   514 LPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLN---------------------------- 550
            .|.....|:|...|.|...|..|||||||::...:|:                            
Human   574 PPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQG 638

  Fly   551 ---RDLILNNLATY---------------STDLVILTNANINIYRSSGGCYTNP---------GY 588
               |...::|.|.|               ...|.:.||:.|   |....|...|         ||
Human   639 HCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKVFTNSKI---RKPKSCSVIPSVSAGAVGQGY 700

  Fly   589 TNCTGSLIGRTMFKNEPTKN---------SGPVPIVGSTRAQASLPPVRKLFPETWLFSNITDVG 644
            ......::.|.......|.|         |||||           ..||..|||||:: .:..|.
Human   701 YGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVP-----------ETVRSYFPETWIW-ELVAVN 753

  Fly   645 ANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIP 709
            ::|...:..|||||:|.|....|.||..:||.::...| :|.|||||:...:||||.||||..:.
Human   754 SSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTAS-LRAFQPFFVELTMPYSVIRGEVFTLK 817

  Fly   710 VIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKK 774
            ..|.|||...::..|.:..|..   |:.:.|         .:.:::..|..|..:.:|:.:.||.
Human   818 ATVLNYLPKCIRVSVQLKASPA---FLASQN---------TKGEESYCICGNERQTLSWTVTPKT 870

  Fly   775 VGLTTLKITAIS----KYAGDRLHQI------------LKVEADGVQKYVNKAVLINVQRLNRRS 823
            :|.....::|.:    :..|:.:.::            |.|||:|:::..      ....:...|
Human   871 LGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGIEQEK------TFSSMTCAS 929

  Fly   824 LAPPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALS 888
            .|...:.:.::...||::.|....|.|.|......::::.:|:.:|.|||||||..|.|:|..|:
Human   930 GANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLN 994

  Fly   889 YLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDA--LGSTWLTAYVIRSFHQAA 951
            ||....:..|||:.||..|:.||||.:||||..|||:|.:|:...  .|:|||||:|:::|.||.
Human   995 YLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFAQAR 1059

  Fly   952 KYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSHGSPL----ALTSFVLLTFFENEEYMPK 1012
            .||.||:..:...|.:|...|..:|.|:..|.:::|:....:    .|:::|.:...|..  :|.
Human  1060 SYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIP--LPV 1122

  Fly  1013 YKHVIDRAVEF-------VVTEVHQSNEPYDLAIAALALSLARNRNAYK-VLDKLDKLATRRGDH 1069
            ...::..|: |       |..|....:..|..|:.|.|.||...:|..: :|:.|||.|.:..:.
Human  1123 TNPIVRNAL-FCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNL 1186

  Fly  1070 KWWTGSDKCK------------SSEVETTSYVLLALLEHNISDEPKP----------IVDWLISK 1112
            ..|....:.|            |:|||.|||||||.|    :.:|.|          ||.|::.:
Human  1187 VHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYL----TAQPAPTSGDLTSATNIVKWIMKQ 1247

  Fly  1113 RNSNGGFVSSQDTVVGIMALTKYELQSHASTEAI------DIEFWHLNEDKKHVRVTKENEFKVQ 1171
            :|:.|||.|:|||||.:.||::|...:...||..      |.:.:..|     .:|...|...:|
Human  1248 QNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTN-----FQVDNNNLLLLQ 1307

  Fly  1172 THQLPENTNEVKLLAKGQGRAQVQLTYRYNV-ATKEARPSFKLTTTVKKS---HKGRLILGICGT 1232
            ...|||...|..:...|:....:|.:.:||: ..||..|......||.::   ||......|..|
Human  1308 QISLPELPGEYVITVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLT 1372

  Fly  1233 YTPIAASERNKTTNMALMQVQLPSGYVCDIEPFAD-IEAISDVKRVETKNEDTEVHIYFEKLSPG 1296
               |:.:.....:||.::.|::.||:: .::|... :|..|.|.|.|..|  ..|.||.|::: .
Human  1373 ---ISYTGNRPASNMVIVDVKMVSGFI-PLKPTVKMLERSSSVSRTEVSN--NHVLIYVEQVT-N 1430

  Fly  1297 DRKCLTLEAIYTHAVANLKPSWVRLYDYYAT 1327
            .....:...:....|.:|||:.|::||||.|
Human  1431 QTLSFSFMVLQDIPVGDLKPAIVKVYDYYET 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 26/84 (31%)
A2M_N_2 411..542 CDD:285005 34/139 (24%)
A2M 634..726 CDD:278630 36/91 (40%)
A2M_2 859..1135 CDD:239227 106/311 (34%)
A2M_comp 910..1135 CDD:284982 85/260 (33%)
A2M_recep 1245..1335 CDD:284981 26/84 (31%)
PZPXP_011519106.1 A2M_N 128..220 CDD:280081 27/92 (29%)
A2M_N_2 457..602 CDD:285005 35/144 (24%)
A2M 744..834 CDD:278630 36/91 (40%)
SVA <796..891 CDD:283081 27/106 (25%)
A2M_2 964..1270 CDD:239227 106/312 (34%)
A2M_comp 1016..1272 CDD:284982 86/262 (33%)
A2M_recep 1382..1464 CDD:284981 26/84 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149982
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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