DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and cd109

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_697512.6	Gene:	cd109 / 569058	ZFINID:	ZDB-GENE-120215-253	Length:	1487	Species:	Danio rerio

Alignment Length:	1513	Identity:	405/1513 - (26%)
Similarity:	689/1513 - (45%)	Gaps:	252/1513 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYV 67
            :||..|.:|.|       |:.:.|:...|   |.|.:.|....|...|.|:.:.:.....|.:.:
Zfish    31 YLISVSEVLRC-------GVPTTLSVTVL---SDYPINVTARLTHGKTSVAQTQSTVPAGSSRLL 85

  Fly    68 DVQSMSSKSVRFDIPKLTEGDYELKVMGSGG--IEFQNSTKLSFAPDLNWLYIQSDKATYKPGDK 130
            .:..:....:.:..|      |:|.|.|..|  :.|.|||.:.|:|....::||:||..|:||..
Zfish    86 SLPPVFYDDMTYWYP------YQLNVEGFSGTHLVFSNSTSMVFSPRCMSIFIQTDKNYYQPGQT 144

  Fly   131 IQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTA 195
            ::|||:.:..:.:|  ......|.|||...|:|:.|..:....||.|.||.:|..|.||:|.:||
Zfish   145 VKFRVVSVTPDGKP--YSGRTDIFIRDPRGNMIRQWLAVDSFLGVISKELNISQNPPLGSWKITA 207

  Fly   196 TVQD---EGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHV-VATI 256
            .|.|   |...|    ||.||:|:|| |.|...:|......:..|:.|:|.:.|||.|.: |..:
Zfish   208 GVNDVIHERAFT----VDYYVLPRFE-VKLDVPSVLYCEDTLMGTVTAKYFYGKPVSGFMDVRFV 267

  Fly   257 EG--------SSTEQSLPIDGEVNVEFPISATAKR----------------LLKITAIVTEELTD 297
            .|        ..||.   |:|...:.|.:...:.|                .:.:...:||..|.
Zfish   268 HGFNGIEMRYDHTEM---IEGSAEITFDMKDFSTRFNDYSYSYYDGYRPIEFIDVNVNITESATG 329

  Fly   298 IKHNGTAYVTVHQHRHKLEDLFWPTHYRPG----------------------VSSEFKTVVR--- 337
            :.:|.:|.|::...::|||.|.:|...:|.                      :.|.:..|.:
Zfish   330 LMYNSSARVSIVTEKYKLEFLQYPHIVKPSMTFTAKLKLSLYDQRPLSAEDQIESVYLAVTQHKL 394

  Fly   338 ----------------------------NLDGSP----VMDSSKMVNFNVLCCQVSKNFSASLQN 370
                                        |.||.|    :|:|:...:|..:       :...:||
Zfish   395 SPWTWMWSDGGPLGPRMMNNTPSTSFPPNSDGGPLGPHMMNSTPPTSFTPI-------YDLPVQN 452

  Fly   371 SIATEHIMLPETCQSCL--------------VTSTF-DTAENIERY-IYKLNKPLMIAIN-TKKP 418
                  |.||.|....:              :.:.| ||.::::.| .|.......|.:: ..:|
Zfish   453 ------IELPVTADGLMSFQIHLSDSVATLDLEARFKDTVQHLQLYRSYSSPSKSYIQLHRDSEP 511

  Fly   419 QLRKLLKINIISD---TYLPYFILT---VVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQAT 477
            |:.:.|...:.|.   |.:.|.:.:   ||..|.:            :|............|||.
Zfish   512 QVGRSLNFTLESSFNLTKIHYLVTSRAGVVDAGTV------------QSSSFSLNTDHLWAPQAC 564

  Fly   478 IFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVK-TNPHSFVGLLGVDQS 539
            :.|:|.: ||.:::|...|...:...||:.: .:.:.|.|.:.|||.|. :.|.|.:|:|.||::
Zfish   565 VMVYYTLPDGEIVNDALHVSFTKVLRNTVSVRWSQDRAEPAESVSLSVSVSEPGSVLGILVVDKA 629

  Fly   540 VLLLRSGNDLNRDLILNNLATYSTDLVILTNANINI---YRSSGGCYTNPGYTNCTGSLIGRTMF 601
            .|.....|.|:...:|....:||.::....|..:.:   |    ..:|..|.|..|.:.:.:.|.
Zfish   630 TLNSAEDNGLSEKTVLEEFLSYSREMTHTDNRGMKMGDPY----SVFTACGVTVLTDARLNQEMA 690

  Fly   602 KNE------PTKNSGPVPIVGSTRAQASL--PPVRKLFPETWLF--SNITDVGANGEYIIKETVP 656
            .|:      |    |...:..:....:|:  |..||.|||||::  :|::|   :...:...|||
Zfish   691 TNQEMFPMFP----GEEGLFMTAMPDSSIQEPRQRKDFPETWIWLDANVSD---SASAVFSLTVP 748

  Fly   657 DTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVK 721
            |:||||......:|...||.::. |:.:.||:.||::.:||..:.|||::.:.|.:|||:.:|::
Zfish   749 DSLTSWAAFAIIMSENLGLGISA-PAELTVFRDFFMSLDLPAFLIRGELLLLEVNLFNYMDVDLE 812

  Fly   722 AKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAIS 786
            ..|::..| |.:||:.|.:.:.|  :..||  |.|.:..|... :.|.|:...:|...:.:.|.|
Zfish   813 VIVVVAES-GMFEFVSTDSADFS--VANVR--KVLVLSQNFTM-LLFPIKATTLGEIPISVKATS 871

  Fly   787 KYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKADNVIEGSETVEFEVC 851
            .|:.|.|::.:.|:.:|:|:...:.:.:.. .|.:.:|:  .|......|| |:..|:.......
Zfish   872 VYSSDWLYKTVLVKPEGLQQSFTQTLFLEF-LLQQHTLS--RKMTFSFPAD-VVPNSQRASVSAV 932

  Fly   852 GTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIEL 916
            |....|.:.:||.|:.:|.|||||||.:|.|:...|.|||:..:.:::...||..|:...|:.||
Zfish   933 GDILGPSIGNLDSLIEMPYGCGEQNMIHFAPNTYVLQYLKSTKQAEEQTRRKAMSYMMEAYEREL 997

  Fly   917 NYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKEL 981
            :|:|.||||||:|..|..|||||:|:|:|.|.||..:|.|:..|:.....:||:.|.:||.|:|.
Zfish   998 SYQRVDGSFSAFGDSDESGSTWLSAFVLRCFLQARDFISIEPLVMERTAFWLVAHQESDGSFREP 1062

  Fly   982 GMVIHNS-----HGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQS-NEPYDLAIA 1040
            |.|||..     .|| ::||::||:...|:.:|...:|..:..|:.|:.:.:.|. :..|.|::.
Zfish  1063 GQVIHTELQGGLDGS-VSLTAYVLIALLEDAKYESTHKDSVSLALSFLTSRLAQGISSNYSLSLV 1126

  Fly  1041 ALALSLARNRNAYKVLDKL-------DKLATRRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNI 1098
            |.|||||::..|...|..|       |.:.|.|........|.:.:|:::|..:||||.:....:
Zfish  1127 AYALSLAKSSAAPSALTTLLNRALVIDGVPTWRSPGSVLYDSWQPRSADIEIAAYVLLTMHSLRL 1191

  Fly  1099 SDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHV--- 1160
            .||...::.||..:||..||:.|:||||:.:.||:.|  .:.:|.|::|:.. .:||....|
Zfish  1192 MDEGFALMKWLSQQRNHLGGYGSTQDTVMALHALSVY--ATFSSAESMDLTI-RVNEGSGTVATF 1253

  Fly  1161 RVTKENEFKVQTHQLPENTN---EVKLLAKGQGRAQVQLTYRYNVA------------TKEARPS 1210
            .:.|.|....|:|.||..:.   ::::.|:|.|.|..|||..|||.            |.||
Zfish  1254 SIDKSNYLLQQSHDLPIESKDGVDIEVEAEGTGFALFQLTVFYNVMNVRRSLRRRDIHTDEA--- 1315

  Fly  1211 FKLTTTVKKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVK 1275
            |.|...:....:..:.|..|   ..:...:....|.||::.|.|.:|:....:   .::....|:
Zfish  1316 FYLYVDIMDKEEYHVNLYTC---FRLRGGQGLNQTGMAILDVGLLTGFSLAQD---GVQIDDTVR 1374

  Fly  1276 RVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYY----ATERSATEFYH 1336
            ||||.:  ..|.:|.:|::..: :|:.:..:....||.::.:.:.:||||    .|.||.|....
Zfish  1375 RVETPS--GRVILYLDKVTTVE-QCIEISTVMDFKVAGVQDAVIMIYDYYEPRRRTVRSYTSERR 1436

  Fly  1337 VDTSLCDICHGNECGNMC 1354
            .|.|:|..| |::| ::|
Zfish  1437 RDMSVCSFC-GSDC-SLC 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	32/87 (37%)
		A2M_N_2	411..542	CDD:285005	34/140 (24%)
		A2M	634..726	CDD:278630	31/93 (33%)
		A2M_2	859..1135	CDD:239227	106/288 (37%)
		A2M_comp	910..1135	CDD:284982	86/237 (36%)
		A2M_recep	1245..1335	CDD:284981	25/93 (27%)
cd109	XP_697512.6	A2M_N	129..220	CDD:280081	34/96 (35%)
		A2M_N_2	510..632	CDD:285005	33/133 (25%)
		A2M	727..817	CDD:278630	31/93 (33%)
		A2M_2	939..1228	CDD:239227	106/289 (37%)
		A2M_comp	991..1230	CDD:284982	87/241 (36%)
		A2M_recep	1347..1431	CDD:284981	23/89 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584112
Domainoid	1	1.000	75	1.000	Domainoid score	I8988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm24980
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860