DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep1 and c3b.2

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:XP_009294666.1 Gene:c3b.2 / 566347 ZFINID:ZDB-GENE-030131-3063 Length:1769 Species:Danio rerio


Alignment Length:1697 Identity:369/1697 - (21%)
Similarity:636/1697 - (37%) Gaps:508/1697 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSV------------SLTGPSLNS------------ 63
            :|:|||..:|..:..|::|..||..:..:|:|            |....||||            
Zfish    47 FSLLAPAKIRPGTKQNILVEGHNLAKVVKVTVVVYDYPNSQTALSRGSVSLNSDNNYSVLQTLEI 111

  Fly    64 ----------RKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYI 118
                      :|||.:.:..|...|.:           |||   .:.|::          ..::|
Zfish   112 NPNLLLPDGKKKYVKLVAQFSNIYRAE-----------KVM---AVSFRS----------GHIFI 152

  Fly   119 QSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLS 183
            |:||..|.||||::||....|...|.:  ::.|.:||::.|...:.....:|...||:|....||
Zfish   153 QTDKPIYNPGDKVRFRAFVSDLEFRSS--ERTISLEIQNPDGIAVHGIGRVKAIDGVFSDIFSLS 215

  Fly   184 DRPVLGNWTVTATVQDEGKVTNV----LVVDKYVVPKFEVVVLTAK--NVAASAGYIRATIKARY 242
            .....|.|.|.|.. |:|| .||    ..|.|||:|.|. |.||.|  :::..|..:...|.|||
Zfish   216 TVVKEGRWKVVAKF-DQGK-ENVFSREFEVKKYVLPAFN-VTLTPKTSHLSLDAEKLEVEITARY 277

  Fly   243 TFKKPVKG--HVVATIEGSSTEQSL-------PIDG--------EVNVEFP-ISATAKRLLKITA 289
            .:...|||  :|:..||.:..::.|       .::|        |:...:| |::.....:.:.|
Zfish   278 LYGAQVKGVAYVLFGIEINGEKKRLTSMKQIDDLNGGSVSLTMEEIKRAYPDINSLLGSTVYVKA 342

  Fly   290 -IVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNF 353
             ::|...:|:.....:.:.:....:.|.....|.:|:||:......:|.|.||||..:....|.|
Zfish   343 SVLTSSGSDLVEAEKSGIKIVNSPYMLTIKDTPKYYKPGLPLAMTVIVSNHDGSPTPNIPVKVTF 407

  Fly   354 NVLCCQVSKNFSASLQNSIATEHIMLP--------------ETCQSCLVT-------------ST 391
                    .....|:.:.....||.:|              ||....|..             ||
Zfish   408 --------LKRPISVHSGTINIHINMPKKRIPYGNSQMLKVETVDPSLKPEQQAIQEVYVKPYST 464

  Fly   392 FDTAEN-------IERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVL 449
            |.:..|       ..|.:...:..:.:.|.:..|..|.|::       :|.|.:|.   :|.|: 
Zfish   465 FRSHGNYLHVSVGASRVVVGGSISVQVYIKSSLPNHRALVE-------HLTYIVLN---KGKII- 518

  Fly   450 SLFQEMKEKKKSQEI---------EFEPTFALVPQATIFVHYIID----GVLMSDEKTVDIERDF 501
               |..:...|.|::         |..|.|..|      .:|::.    ..:::|...||:|...
Zfish   519 ---QAGRVNVKGQDVTSVHLLITSEMLPAFRFV------AYYVLPWQHRAEVVADSVFVDVEDRC 574

  Fly   502 ENTI-------EILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLI----- 554
            ..::       ||:::..  |......:||.:..:.|.|:.||.::.|| |.|.|.:..:     
Zfish   575 VGSLNVGPVDGEIVSSYS--PGSSFKFQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKKVWEVVD 636

  Fly   555 -----------LNNLATYSTDLVILTNANINIYRSSGG--------------------------- 581
                       .:|:..:|       :|.:..:.|:||                           
Zfish   637 QADMGCTAGGGKDNMGVFS-------DAGLMFHSSTGGSTDSKEDCSSKTKRRRRSAAKLQLRDQ 694

  Fly   582 --------------------------CYTNP-----------GYTNCTGSLIGRTM--FKNEPTK 607
                                      ||...           .:..|.....|..:  ....||.
Zfish   695 LEKAYSDELLQRCCVDGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGEELGVITRPPTT 759

  Fly   608 NSGPVPIVGSTRAQASLPP---------------------------------------------- 626
            .:.|.....:|    |||.                                              
Zfish   760 TAPPTTAPPTT----SLPTLFDLPYLEYDYMEEKVILRARMIEPMPKLYARANDVGVRQDSYREV 820

  Fly   627 -------------------------VRKLFPETWLFSNI---TDVGANG--EYIIKETVPDTLTS 661
                                     ||..|.|:||:::|   :...::|  .:.:...:||::|.
Zfish   821 VVEEEEEEAASVFEEDDLSDLEDIYVRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSITQ 885

  Fly   662 WVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLM 726
            |.....|.||:.|:.|. .|..:||::||||...||:||.|.|.:.|..::.||....::..|: 
Zfish   886 WGFLAVSASPEKGVCVA-EPYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEVMVI- 948

  Fly   727 DNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAI-SKYAG 790
                     :|.|....|....|..|:: :.:.|.:.:.|::.|.|.|.|...|::||: :.:.|
Zfish   949 ---------LEKTEDMCSVAYTGQHRQQ-VTVAAGSSKLITYTIIPLKTGELPLQVTAVAASFMG 1003

  Fly   791 -DRLHQILKVEADGVQKYVNKAVLIN--------------VQRLNRRSLAP---PEK------TI 831
             |.:.:.|:|..:|:|....::.::|              |::|...::.|   ||.      .:
Zfish  1004 QDAVKKNLRVVVEGIQTLKVRSFVLNPSEKGGSAGQQLIQVKKLQLDAVVPKSVPETFVNVRGDL 1068

  Fly   832 IIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ 896
            :.:..||.|:.                 :.|..|:.:|.||.|||:......::|..||  ....
Zfish  1069 LADSIDNSIKE-----------------DSLAALIRMPGGCVEQNLARITLPLIAAHYL--DRSA 1114

  Fly   897 DQEI-----ENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDI 956
            |.||     ..:|.:|::.||:.:||||::|.|:..:.....  |||:||||::.|..|..:|.:
Zfish  1115 DWEIVGISRREEAIKYIQKGYENQLNYKKSDDSYPPYANEGT--STWITAYVVKVFSMAHSFITV 1177

  Fly   957 DKNVLVAGLDFLV-SRQSTDGKFKELGMVIHNS-----HGS--PLALTSFVLLTFFENEEYMPKY 1013
            ::..|...|.:|: ::|..||.|:|...|...|     .||  ..:||:|||:...|.::.:...
Zfish  1178 NEKHLCGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIALAEAQDKVTCQ 1242

  Fly  1014 KHVID------RAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWW 1072
            ...::      :|..::.....:...||..|||..||:::.|.....:|     |.....||..|
Zfish  1243 DQEVNIRDKSRQAAGYLTEHFSRLTRPYTAAIACYALAVSNNACVKSML-----LKFASPDHSHW 1302

  Fly  1073 TGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYEL 1137
            ..|:....: :|.|.|.||||::....:|.:....||...|...||:.|:|.|:|.:.||::|.:
Zfish  1303 PDSNNYFFT-LEATGYALLALIKSGHMEEAEAPFRWLNEHRGIGGGYGSTQSTMVVLQALSEYLV 1366

  Fly  1138 QSHASTE-----------AIDIEFWHLNEDKKHV----RVTKENEFKVQT--------------H 1173
            :....::           ..|:. |..|.:..:|    ||..:.||.|..              |
Zfish  1367 KRPPPSDLNLLVQLSVPGRSDVR-WTFNPNLAYVARSSRVPLDQEFSVAASGNGKGVLEVVTVYH 1430

  Fly  1174 QLP---ENT--NEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTY 1233
            |||   ||:  |..:|        .|.:.......:.:...||:|...|:               
Zfish  1431 QLPDVYENSTCNGFQL--------DVSIAETNEKTSSDVEKSFRLNVNVR--------------- 1472

  Fly  1234 TPIAASERNKTTNMALMQVQLPSGYVCDIEP-FADIEA--------ISDVKRVETKNEDTEVHIY 1289
               |..||.  ..|.::.:.||:|:    || .:|:|.        |::.:.|:..::...:.|:
Zfish  1473 ---ALEERQ--VRMVILDIGLPTGF----EPENSDLELLTNSVDRYINNFQVVDNLSDRGSLIIH 1528

  Fly  1290 FEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY---HVDTSLCDICHGNEC- 1350
            ..|:|..:.:.::........|..|:||.|::|.||..::|.:.||   .....|..||.|:.| 
Zfish  1529 LFKVSNKEAEIISFRLNQRFKVGLLQPSTVKVYQYYNKDKSCSRFYSPPEDKQQLDQICEGDVCR 1593

  Fly  1351 ---GNMC 1354
               |:.|
Zfish  1594 CSQGDCC 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 28/84 (33%)
A2M_N_2 411..542 CDD:285005 30/150 (20%)
A2M 634..726 CDD:278630 30/96 (31%)
A2M_2 859..1135 CDD:239227 86/294 (29%)
A2M_comp 910..1135 CDD:284982 70/238 (29%)
A2M_recep 1245..1335 CDD:284981 22/98 (22%)
c3b.2XP_009294666.1 A2M_N 150..243 CDD:280081 32/96 (33%)
A2M_N_2 489..620 CDD:285005 30/152 (20%)
ANATO 692..748 CDD:237984 3/55 (5%)
A2M 853..949 CDD:278630 30/106 (28%)
TRAPPC10 <940..>992 CDD:289361 12/62 (19%)
complement_C3_C4_C5 1080..1364 CDD:239226 86/293 (29%)
A2M_comp 1133..1364 CDD:284982 70/238 (29%)
A2M_recep 1481..1574 CDD:284981 22/96 (23%)
NTR_like 1594..1767 CDD:295338 2/7 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584200
Domainoid 1 1.000 56 1.000 Domainoid score I10957
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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