Protein Alignment Tep1 and c4

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_005157429.1
• Gene: c4 / 566261
• ZFINID: ZDB-GENE-030131-5697
• Length: 1700
• Species: Danio rerio
• Alignment Length: 1638
• Identity: 369/1638 - (22%)
• Similarity: 646/1638 - (39%)
• Gaps: 433/1638 - (26%)

  Fly    25 VLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDVQSMS---------------- 73
            ::||..:.......|.|.:|..|:  |:.:.|         |.:.|..|
Zfish    24 IVAPNVIHLGVEETVGVQLHGATK--EIRMKL---------YFEKQKESEILSEIRSIILNENNN 77

  Fly    74 -SKSVRFDIPKLTEGDYE------LKVMGSGGIEFQNSTK--LSFAPDLNWLYIQSDKATYKPGD 129
             ...|:..:.....||.|      |..:.:...|.|::.|  :..:....::::|:||..|.||:
Zfish    78 YQAVVKLKVDATMYGDVEKNSYVQLAAISNDIFEKQDARKANIYLSTKRGYIFVQTDKPIYNPGE 142

  Fly   130 KIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKG--VYSGEL---QLSDRPV-- 187
            .:::|:..||....|  |...:.::|.:              :||  ||:..|   |:.|:.:
Zfish   143 NVKYRIFILDNYMLP--IQDELHVQITN--------------SKGLIVYNRVLIINQILDKTITI 191

  Fly   188 -----LGNWTV----------TATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGY---- 233
                 .|.|.:          |.||:.|        |.:||:|.|||      .:.||..|
Zfish   192 PEVEQTGKWKIITSFHKFPESTTTVEFE--------VKEYVLPTFEV------KIEASQPYHILM 242

  Fly   234 ---IRATIKARYTFKKPVKGHVVATIEGSSTEQS-----LP-IDGEVNVEFPISATAKRLLKITA 289
               ....|.||||:.|.|.|  :|.:.....::.     || .:.::.||   ..||.     ||
Zfish   243 SESFPFNISARYTYGKGVNG--IAYVRFGLVDEKHNKIYLPGTEKQITVE---DGTAG-----TA 297

  Fly   290 IVTEELTDIKHNGT--------AYVTV---HQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSP 343
            ::|::|.....|.|        .|:.|   .:....||:         ..||..|.|.     ||
Zfish   298 VLTKDLKTASQNITQGYIEGYYIYIAVSVLDKASGMLEE---------AESSSVKIVT-----SP 348

  Fly   344 -VMDSSKMVN-------FNVLCCQV--------SKNFSASLQNSIATEHIM-------------- 378
             |:|.||...       |:||....        :..|:|::....::|.|:
Zfish   349 YVVDLSKTKTYFTPGGVFSVLATATYPDGNRAPNLKFTATITIDGSSEQILQNESWGNEMGDVAM 413

  Fly   379 ---LPETCQSCLV------------------TSTFDTAENIERYIYKLNKPLMIAINTKKPQLRK 422
               :|...::..:                  |::..|||.......::.|..:.|....|.:||.
Zfish   414 SFQIPPQAKNLAITVFAEGGDQVVIRSDNKMTASAITAEEQSYLSLEVEKQFLQAGEDLKARLRD 478

  Fly   423 LLKINIISDTYLPYFIL----TVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYI 483
            :........|:. ||::    .:|..|.:..:.|..:..|   ..::..|:|.||  |..|....
Zfish   479 ITPEGAAKPTFF-YFMVWSKGQIVQMGRVPRTAFTTVNVK---VNVDMVPSFRLV--AYYFTGSA 537

  Fly   484 IDGVLMSDEKTVDIERDFENTIEILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGND 548
            ....:::|...||::...:..|||....|..|..:..:.|:|||.:.|.|:.||.:|.:|.. |.
Zfish   538 SKESVVADSVWVDVKDVCKGKIEINPLAEIKPATQFEVTVETNPKTKVALVAVDSAVYILNK-NK 601

  Fly   549 LNRDLILNNLATY-------------------------------------------------STD 564
            |:...:.:.:.:|                                                 :.|
Zfish   602 LSLQKMFDYMNSYDLACSVGGGEDSSAVLQRAGLTFICNCALKTPTALEHKCNKKTTNRVRRAPD 666

  Fly   565 LVILTNANINIYRSS------GGCYTNPGYTNCTGSL-------IGRTMFKN------------- 603
            .|...||.:|.:::.      .|...:...|:|...|       ..|..||.
Zfish   667 YVAKYNAVVNSFKNQDRKCCLDGVRPSKMQTSCVDRLKRVKESESCRKAFKECCEAADERRKREK 731

  Fly   604 -EPTKNS-GPVPIVGSTRAQ----ASLPPVRKLFPETWLFSNITDVGANGEYIIKETV--PDTLT 660
             |..|.| |.|  ||.:..:    ..|..:|..||::|::   |.:.::.:.:|:..|  ||::|
Zfish   732 FEKRKTSLGRV--VGDSFDEIVINEDLIYIRNYFPQSWMW---TVIESDNKGLIRHEVVAPDSIT 791

  Fly   661 SWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVL 725
            :|.:....:||..|..:. .|..:.||:.||::.||||||||.|.:.:..:|:||....:|..|.
Zfish   792 TWEVQAVGISPTKGFCIA-EPKPLTVFKDFFLSVNLPYSVKRNEQLQVKAVVYNYKQESLKVIVK 855

  Fly   726 MDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITA-ISKYA 789
            ::..:|    :.|...|      .|:.:.|  :..|:...:.|.:.|..:|...:.:.| .|:..
Zfish   856 LNKVEG----LCTAGGN------DVKEEVT--VSGNSAVTVYFTVVPLIIGNLHIDVLAYASEII 908

  Fly   790 GDRLHQILKVEADGVQKYVNKAVLI--NVQRLNRRSLAPPEKTIIIEKADNVIEGSE---TVEFE 849
            .||:.:.|:||.:|....:::...|  |::::.....:|         .|.|..||:   ::.|:
Zfish   909 HDRVEKKLRVEGEGELTSIDREFNIDPNLKKIEFNISSP---------VDEVPAGSDSETSLGFK 964

  Fly   850 --VCGTS--QAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNR---QDQEIENKAKRY 907
              |.|.|  ....||.:|.|:.||.||.||.|....|:|.|:.||.|.|:   ...|..::|:..
Zfish   965 GGVMGESIDNCLNLEGIDKLIQLPTGCAEQTMVKMSPAIHAMRYLDATNQWLSLKAERRDEARSM 1029

  Fly   908 VETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQ 972
            ::|||...|.:|::|||:.|:.:..:  |.||||::.:....:...::::|..:...:.:|:|:|
Zfish  1030 IQTGYNTVLTHKKDDGSYGAFLRTPS--SIWLTAFIAKELTGSQDIVNVNKLYIQEAMSYLISKQ 1092

  Fly   973 STDGKFKE---------LGMVIHNSHGSPLALTSFVLLTFFENEEYM-----PKYKHVIDRAVEF 1023
            .::|.:.:         .|.|...:...|  ||:|||::.....:..     .:.:..:|:|..:
Zfish  1093 KSNGAWDDPNRLFDQGMKGGVEQATDDVP--LTAFVLISMHHALKVYDLGSDTELRVAMDKAKSY 1155

  Fly  1024 VVTEVHQSNEPYDLAIAALALSL--ARNRNAYKVLDKLDKLAT------------RRGDHKWWTG 1074
            :..::.....||.||:.|.:.||  .|:..|.|...||..:|.            .||:.|
Zfish  1156 LEAQLDAVRSPYSLAVTAYSFSLHDHRSAEARKAQQKLQDIANCDDKMCFWKAKGGRGEPK---- 1216

  Fly  1075 SDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQS 1139
             ||..:..||||:|.||..|......:.|.|.:||..:|...|||.|:||||:.:.|||||.:|:
Zfish  1217 -DKADARSVETTAYALLTTLIVGDKSKSKLIANWLTEQRRHGGGFRSTQDTVLALEALTKYSIQN 1280

  Fly  1140 HASTEA-IDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVA 1203
            :...:. :.:|....|..||.:.:||.|...:...:: .:..:|.|..:|.||..:.:...|...
Zfish  1281 NDVDDLNLRVEMCLENGQKKDLHLTKNNALTLSAVKV-RDVGKVTLNIQGTGRGTLAVVQTYRTM 1344

  Fly  1204 TKEAR--PSFKLTTTVK----------------------------------------KSHKGR-- 1224
            .|:..  ..|.||.|||                                        :|.:.|
Zfish  1345 KKDESFCDLFHLTVTVKGELEYKTDNSQDLLEDYYESYDTSEAQNDEPMSNMQWFDLRSRRKRQI 1409

  Fly  1225 ---------LILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETK 1280
                     ||..:|     :...::| :..|.::.:.|.||.:.:.:   |:|  .:||..|..
Zfish  1410 SEEPIKESSLIYTVC-----VGLKKKN-SEGMIIVDISLLSGLIPNSK---DLE--HNVKGTEKY 1463

  Fly  1281 NEDTEVH-----IYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY---HV 1337
            .:..|:|     :||.|::..: :||...|.....:..::|:...:||||:.|:....||   ..
Zfish  1464 IDHYEIHHNKVYLYFAKITETE-ECLQFGADQAVPMGLVQPASAVIYDYYSPEKRCGIFYTAPQK 1527

  Fly  1338 DTSLCDICHGNEC 1350
            ...:..:|.|:.|
Zfish  1528 SPMISKLCQGDVC 1540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	24/106 (23%)
		A2M_N_2	411..542	CDD:285005	34/134 (25%)
		A2M	634..726	CDD:278630	30/93 (32%)
		A2M_2	859..1135	CDD:239227	91/306 (30%)
		A2M_comp	910..1135	CDD:284982	71/252 (28%)
		A2M_recep	1245..1335	CDD:284981	23/94 (24%)
c4	XP_005157429.1	A2M_N	128..220	CDD:280081	25/115 (22%)
		A2M_N_2	459..595	CDD:285005	34/141 (24%)
		ANATO	675..731	CDD:237984	8/55 (15%)
		A2M	766..856	CDD:278630	30/93 (32%)
		complement_C3_C4_C5	977..1276	CDD:239226	91/307 (30%)
		A2M_comp	1032..1278	CDD:284982	73/254 (29%)
		A2M_recep	1434..1522	CDD:284981	23/93 (25%)
		NTR_complement_C4	1540..1698	CDD:239639	1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584116
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.810