DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep1 and zgc:165453

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:XP_009297326.1 Gene:zgc:165453 / 566238 ZFINID:ZDB-GENE-070720-13 Length:1455 Species:Danio rerio


Alignment Length:1495 Identity:384/1495 - (25%)
Similarity:636/1495 - (42%) Gaps:270/1495 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDVQSMSSKSVR-------F 79
            |:.|..|..:.|::...:..::.....:..:::||.     ..|..::|.:...|.|       |
Zfish    45 LFLVTFPSLIESDTEAKLCASLLKPKGSVTMTISLV-----DEKSTEIQLVQQTSGRKFHRCFHF 104

  Fly    80 DIPKLTEGD--YELKVMGSG-GIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKN 141
            ..|::: ||  ..::|:..| ..:....:|:.|...|...:||:||..|.||.::.||||.:...
Zfish   105 QAPQVS-GDSVQTVRVVIQGQSFKMTEESKVMFRSYLPLTFIQTDKPLYNPGQRVNFRVLTMSDT 168

  Fly   142 TRPAVIDKPIK-IEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTN 205
            ..|.  |:... :.:.|.::..|:.|.||.....:......|.....:|.:|:.|.:.|. .::.
Zfish   169 FVPQ--DQMYSLVVVEDNNKIRIRQWTDISSTNWILELSHVLDKEAQVGTYTLKAYIGDR-TISQ 230

  Fly   206 VLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHV------------------ 252
            ...|.|||:|||::.:.|.:....:...::....|:||:.:||.|.|                  
Zfish   231 SFDVKKYVLPKFDMTLNTPQTYNVADVGLKVEACAKYTYGQPVPGQVSVNLCRQHFTFIQDPKVT 295

  Fly   253 --------------------VATIEGSSTEQSLPIDGEVNVEFPISATAKRLLKITAIVTEELTD 297
                                .:|..|:|.|.||.....|||.                :||:.||
Zfish   296 ICLNETALMDDTGCTSLTFSTSTFFGTSLESSLQNSFVVNVN----------------LTEQGTD 344

  Fly   298 IKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVN---------- 352
            :..:.:|.|::.....|:..:..|..|..|.:...|..|.:.:|:.:  |:|:|.          
Zfish   345 VVMSKSATVSITYEVGKVTFVDLPKFYDYGSTINAKISVSDFNGNAI--SNKVVYLLDHGQWRPK 407

  Fly   353 --FNVLCCQVS-KNFSASLQN----SIATEHIMLPE----------TCQSCLV----TSTFDTAE 396
              |||...:.. ..||.:..|    ::.....::|:          |..|.:|    |:..|...
Zfish   408 VLFNVTTDESGLAEFSLNTTNFPKANLYLVASVIPQLWFNDNSPHFTTDSQVVQLSQTAAPDNPT 472

  Fly   397 NIERYIYKLNKPLMIAINTKKPQLRKLLKINIISDT--YLPYFILTVVARGNIVLSLFQEMK--- 456
            ..:..|..|.:||  ...|..|   ..:|...:.:|  |....|..|::||.|||..|:.::   
Zfish   473 YSDLSIVSLQQPL--KCGTTYP---VTVKYTFVGETGDYSADIIYMVMSRGVIVLHGFKTVQAWA 532

  Fly   457 -EKKKSQEIEFE-PTFA-LVPQATIFVHYIIDG-VLMSDEKTVDIERDFENTIEI-LTTNEALPR 516
             :...:..:.|: |..| :.|...|.|..::.. .:::...:.|.|:.|.|.:.: .:...|:|.
Zfish   533 SDTLTTGTVTFDLPVHAKMAPMVQILVFSVLPSETVVTGSASFDTEKCFSNQVSLQFSPATAVPG 597

  Fly   517 DEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILN-----NLATYSTDLV---------- 566
            :...|.|.....|..||..:|||||:::||..|:.:.:.|     :|:.|...:.          
Zfish   598 EGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAMFNLLPVRSLSDYPPGVEDQQNCLNVRP 662

  Fly   567 ---ILTNANINIYRSSG------------GCYTNPG---YTNCTGSLIGRTMFKNEPTKNS---- 609
               :.|:...|.::..|            .|.|..|   |.|..|.|.       .|.::|    
Zfish   663 LRDVPTDQAYNTFKGVGIKTATNLPVREPPCLTYRGLSYYRNFPGVLY-------SPVESSDLVL 720

  Fly   610 -GPVPI-VGST---RAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSW------- 662
             .|||: :|..   .:.:|...:|..|||||::..:| ||.:|...:..|||||:|:|       
Zfish   721 NAPVPVELGELVRGDSGSSAVTIRTYFPETWIWQLVT-VGDSGSTSVPLTVPDTITAWDTEAFCL 784

  Fly   663 VITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMD 727
            ..:||.|:|         |..:..|||||:...||||:.|||::.:...|||||...:|.:|...
Zfish   785 ASSGFGLAP---------PVLLTSFQPFFLEITLPYSIIRGEILNLKATVFNYLPQCIKVQVTPT 840

  Fly   728 NSDGQYEFIETTNKNVSQYLRGVRRKKTLW-IPANTGRGISFMIRPKKVGLTTLKITAISKYA-- 789
            .|.   .|...:..:.|.:|....||...| :.|:.              :.|:.:| ||..|  
Zfish   841 PSS---NFTLKSFGHYSSHLSANGRKTFKWDLTASV--------------IGTINVT-ISAQASP 887

  Fly   790 GDRL--HQILKVEADGVQKYVNKAVLI---NVQR-LNRRSLAPPEKTIIIEKA-----DNVIEGS 843
            .::|  :|::.|.:.|....|.:::|:   .|:| ..|..|..|:.:|:.|..     ..||:||
Zfish   888 SEQLCDNQLVTVPSRGHTDIVTRSLLVLAEGVERTFIRNWLLCPKGSILSESVKITFPTKVIQGS 952

  Fly   844 ETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYV 908
            ........|......|::|.:|:.:|.|||||||....|:|..|.|||...:....|::.|..|:
Zfish   953 ARCSVSAIGDIMGRALKNLANLLQMPYGCGEQNMIILAPNIYTLQYLKVTAQLTPAIQDTAASYL 1017

  Fly   909 ETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQS 973
            .:|||.||||:.:|||||.:....:  :||||.:|:|:|..|..:..||.|||.:..|:|:..|.
Zfish  1018 LSGYQRELNYRHSDGSFSTFPYSPS--NTWLTTFVMRTFGLARNFTYIDPNVLQSAKDWLIGTQG 1080

  Fly   974 TDGKFKELGMVIHNSH----GSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQSNEP 1034
            :||.|.:.|.:.|...    ...:.:|.:::.:..|..  :|....||.:|:.|:...|......
Zfish  1081 SDGCFVQQGTLYHKDMKGGVDDNVTMTGYIVASMLEIG--VPVTDPVITKALSFLRPLVGNLGNT 1143

  Fly  1035 YDLAIAALALSLA-RNRNAYKVLDKLDKLATRRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNI 1098
            |..|:.|...||| ......::|:.|...|...|....|:.:....:..||.::|||||:|    
Zfish  1144 YVTALLAYTFSLAGETSTRAQLLNSLRNTAISEGTTLHWSQTTSGDTLAVEISAYVLLAVL---- 1204

  Fly  1099 SDEP---------KPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQ--SHASTEAIDIEFWH 1152
            :.:|         ..||:||::::|..|||.|:|||||.:.||:.|..|  |...:..:.::...
Zfish  1205 TVQPVTTANLGYANRIVNWLVAQQNPYGGFSSTQDTVVALQALSMYAAQVFSPGGSSTVTVQSSV 1269

  Fly  1153 LNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTV 1217
            ...|..:..||..|....|...|........::|.|...|.||:...||:.| ..|.|..|:...
Zfish  1270 PAGDVFNFDVTPNNRLLYQESPLNNFPGTYSVVAAGAACASVQVLCFYNIPT-PVRVSKTLSVVA 1333

  Fly  1218 KKSHKGR-----LILGICGTYT-PIAASERNKTTNMALMQVQLPSGYVCDIE------PFADIEA 1270
            |.|...:     |:|.....|| |      ..||||.|:.::|.||:..|..      .||.:  
Zfish  1334 KVSGNCQATPVNLMLTFTAKYTGP------KPTTNMVLVDIKLLSGFTADTSLLGSPPNFAPL-- 1390

  Fly  1271 ISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY 1335
               |:||:  :|...|.||.:::..|.....:::...|.||.||||:.:.:||||....|....|
Zfish  1391 ---VQRVD--SEGDHVLIYLQEVPKGVPVTFSIQLTQTVAVQNLKPAVINIYDYYQRSDSFETAY 1450

  Fly  1336  1335
            Zfish  1451  1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 23/85 (27%)
A2M_N_2 411..542 CDD:285005 34/140 (24%)
A2M 634..726 CDD:278630 37/98 (38%)
A2M_2 859..1135 CDD:239227 97/289 (34%)
A2M_comp 910..1135 CDD:284982 77/238 (32%)
A2M_recep 1245..1335 CDD:284981 30/95 (32%)
zgc:165453XP_009297326.1 A2M_N 143..234 CDD:280081 23/93 (25%)
A2M_N_2 478..622 CDD:285005 37/148 (25%)
A2M 750..838 CDD:278630 36/97 (37%)
A2M_2 967..1250 CDD:239227 97/290 (33%)
A2M_comp 1019..1252 CDD:284982 78/240 (33%)
A2M_recep 1361..1450 CDD:284981 30/95 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584132
Domainoid 1 1.000 217 1.000 Domainoid score I2610
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 517 1.000 Inparanoid score I1243
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm6406
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.700

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