DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and c3a.3

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001032313.2	Gene:	c3a.3 / 565074	ZFINID:	ZDB-GENE-990415-37	Length:	1651	Species:	Danio rerio

Alignment Length:	1623	Identity:	378/1623 - (23%)
Similarity:	654/1623 - (40%)	Gaps:	404/1623 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD 68
            |.||:.:|...||:..:.||.:.||..||..|:.||.|...:          .:|..||.|  :.
Zfish     6 LFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQD----------YSGGPLNVR--IS 58

  Fly    69 VQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLN------------------- 114
            |::..:|:|          :...|.:...|.::|:.|.:....|.|
Zfish    59 VKNFPAKNV----------EMMQKTVTLTGAKYQSLTDIQIPGDRNYFSDDEKKQYVYLQAHFPS 113

  Fly   115 --------------WLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKP-IKIEIRDGDQNLIK 164
                          :|::|:||..|.||..:.:|:..:..|.:|  ..|| |.::|.: .|.:..
Zfish   114 VTLEKVVMVSFQSGYLFVQTDKPIYTPGSNVHYRIFSMTPNLKP--FSKPGITVDITN-PQGITV 175

  Fly   165 SWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLTAKN- 226
            :...|...|||.|....:.:...||.|.|.....:  :...|....|.:||:|.|||.:.|:|:
Zfish   176 ASDTIFAEKGVKSSIYNIPEVTSLGMWKVVTRYANTPQKTFTAEFEVKEYVLPTFEVKLKTSKSF 240

  Fly   227 --VAASA------GYIRATIKARYTFKKPVKGH---VVATIEG-------SSTEQSLPIDGEVNV 273
              |..|.      ..:...::|:|.|.|.:.|:   |...::|       :|.::....:|....
Zfish   241 YYVGDSKPKNNEDDSLTVDMEAKYLFGKKMDGNAFVVFGVMDGAMKTSIVNSLQKVQVFNGVGTA 305

  Fly   274 EFP---ISATAKRLLKITA--------IVTE---ELTDIKHNG----TAYVTVHQHRHKLEDLFW 320
            |..   |:.|.|.:..:..        ::||   |:.:.:..|    |:..|:|..|..
Zfish   306 ELTREMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKRTS------ 364

  Fly   321 PTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETCQS 385
             ..::||:.......|.|.|.:|..|    |...||...|....|.:..|.||...:.......:
Zfish   365 -QFFKPGMPLGVSVYVTNPDETPAED----VEVEVLVDGVGGVNSKTKANGIAKVTVNTKAGVST 424

  Fly   386 CLVTSTFDTAE----------------------------NIERYIYKLNKPLMIAINT-KKPQLR 421
            ..:|:|....|                            |||...:::...:.:.:|| :.|.
Zfish   425 LKITATTRDPELANEQQADKTMIAQAYKTNLGSKNYLHINIESAEFEIGDQMTVYLNTGESPG-- 487

  Fly   422 KLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQ-----EIEFEPTFALVPQATIFVH 481
                   :.|....|.||   ::|.|||:      |:.|.|     .:....|..:||......:
Zfish   488 -------VKDQDFTYMIL---SKGQIVLA------ERFKRQGQTLVSLSLPVTKDMVPSFRFVAY 536

  Fly   482 YII--DGVLMSDEKTVDIERDFENTIEILTTNEAL---PRDEVSLKVKTNPHSFVGLLGVDQSVL 541
            |.:  |.| :||...||::......:::..|.:..   ..:||:|::..:..:.|||:.||::|.
Zfish   537 YHVGKDEV-VSDSVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGARVGLVVVDKAVQ 600

  Fly   542 LLRSGNDLNRDLILNNLATYSTDLVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEP- 605
            :|.. |.|.:..|.:.:..:.|..            :.||...:.|..:..|     .||:::|
Zfish   601 VLNK-NRLTQSKIWDVIEKHDTGC------------TGGGGKDSMGVFSDAG-----LMFESDPA 647

  Fly   606 ------TKNSGPVPIVGSTRAQASLPPV------------------------------------- 627
                  |:...|.|.....|:: ||..:
Zfish   648 GGTNTRTEPKCPAPPKRKRRSE-SLQTITTTLAGQYTEKIRPCCYDGMRNNRIGYTCERRASYVI 711

  Fly   628 --------------------------------------------------RKLFPETWLFSNI-- 640
                                                              ||.|||:||:...
Zfish   712 DGEECVKAFLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQFPESWLWEEFDL 776

  Fly   641 ----TDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVK 701
                :....|....:|    |::|:|.|...||||..|:.|. .|..|.||:.|||...:|||..
Zfish   777 CDKCSKPSKNKVTYLK----DSITTWQILAISLSPTHGICVA-EPEEIVVFKSFFIDLKVPYSAV 836

  Fly   702 RGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGI 766
            |||.:.|..|:.||....:| ||       :.||:||.....:...:| :.:.|:.:..::...:
Zfish   837 RGEQVEIKAIIHNYTPKHLK-KV-------RVEFLETAGVCSAASKKG-KYRATVNVDKDSSIAV 892

  Fly   767 SFMIRPKKVGLTTLKITA-ISKYAGDRLHQILKVEADGV-QKYVNKAVLINVQRLNRRSL----- 824
            ||:|.|..:....:::.| |..|. |.:.:.|||.::|| .|:.::.:.:|..:...:.|
Zfish   893 SFVIVPMTLESQHIEVKASILDYT-DGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQPLLLRAG 956

  Fly   825 -------APPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVP 882
                   ..|..:.|....:.:   |:::|..:.|:       .:.:|:..|.|||||||.....
Zfish   957 IPGDQVPGTPVHSYITVTGEEI---SQSIEHAINGS-------FMGELIKRPGGCGEQNMAKMTL 1011

  Fly   883 SILALSYLKAKNRQDQ---EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVI 944
            .::|..||...|:.:.   :....|..:::|||..:|.|::.|||::.|  .:...||||||||.
Zfish  1012 PVVATHYLDNTNQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAIW--INTPSSTWLTAYVA 1074

  Fly   945 RSFHQAAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIHNS-------HGSPLALTSFVLL 1001
            :.|..|..:..|::||:.:.|.:|| .:|..||.|||...|...|       ..:.::||:|||:
Zfish  1075 KVFAMANDFFAIEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNTDVSLTAFVLI 1139

  Fly  1002 TFFENEEY----MPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKL 1062
            ...|.:|.    :......:.:||.|:..::.:...||.:|:.:.||:.|         |.|:|.
Zfish  1140 AMQEGKEICGGTVGSLHESMRKAVAFLKDQLPKLTNPYAVALTSYALANA---------DSLNKA 1195

  Fly  1063 -----ATRRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSS 1122
                 :|:..|.::|...:: :...:|.|:|.:|||::....|.....|.||..:::|:||:.::
Zfish  1196 ILMMHSTKVNDERFWNVPER-QYYSIEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTT 1259

  Fly  1123 QDTVVGIMALTKYELQSHASTEAIDIEFWHLNED------KKHVR--VTKENEFKVQTHQLPENT 1179
            |.|::...|:.:|    ||.|:  |:..:.||.:      :|..|  :.:.|....::..:..|
Zfish  1260 QVTIMVFQAVAEY----HAQTQ--DLNNFDLNVELVVPGRRKTDRWTIQRSNVHLARSGNVDLN- 1317

  Fly  1180 NEVKLLAKGQGRAQVQ-LTYRYNVATKEARPSFKLT------TTVKKSHKGRLILGICGTYTPIA 1237
            .:..::|||.|.|.:. ||..|      |||..|.|      .:||.........|..|||..|.
Zfish  1318 KDFTVIAKGTGSAILSVLTLYY------ARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTYNFIL 1376

  Fly  1238 ----ASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVK-RVETKNEDTEV-------HIYF 1290
                .:::|..| |.::.:.||:|:  ||:. ||::.:|..| |...|.|..:|       .||.
Zfish  1377 DFFYKNKKNDAT-MTILDIGLPTGF--DIDE-ADLKQLSTGKERYIQKYEKNKVLSERGSLIIYL 1437

  Fly  1291 EKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYH---VDTSLCDICHGNEC 1350
            .|:|....:.|......|..||.|:|:.|.:|:||:.:....::||   .|::|..:|.|:.|
Zfish  1438 NKVSHEVSEKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLC 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	24/87 (28%)
		A2M_N_2	411..542	CDD:285005	34/141 (24%)
		A2M	634..726	CDD:278630	34/97 (35%)
		A2M_2	859..1135	CDD:239227	85/295 (29%)
		A2M_comp	910..1135	CDD:284982	71/241 (29%)
		A2M_recep	1245..1335	CDD:284981	29/97 (30%)
c3a.3	NP_001032313.2	A2M_N	128..222	CDD:280081	25/96 (26%)
		A2M_N_2	463..599	CDD:285005	36/154 (23%)
		ANATO	674..737	CDD:237984	0/62 (0%)
		A2M	768..861	CDD:278630	34/105 (32%)
		complement_C3_C4_C5	987..1272	CDD:239226	86/303 (28%)
		A2M_comp	1042..1272	CDD:284982	71/241 (29%)
		A2M_recep	1387..1482	CDD:284981	29/98 (30%)
		NTR_complement_C3	1502..1649	CDD:239638
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584188
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800