Protein Alignment Tep1 and c3b.1

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_009294664.1
• Gene: c3b.1 / 563665
• ZFINID: ZDB-GENE-030131-2211
• Length: 1768
• Species: Danio rerio
• Alignment Length: 1692
• Identity: 377/1692 - (22%)
• Similarity: 643/1692 - (38%)
• Gaps: 498/1692 - (29%)

  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSV-------SLTGPS-----LNS------------ 63
            :|:|||..:|..:..|::|..||..:..||:|       |.|..|     |||
Zfish    46 FSLLAPAKIRPGTKQNILVEGHNLAQVVEVTVVVYDYPNSQTALSRGSVFLNSDNNYSVLQTLEI 110

  Fly    64 ----------RKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYI 118
                      :|||.:.:..|...|.:           |||   .:.|::          ..::|
Zfish   111 NPNLLLPDGKKKYVKLVAQFSNIYRAE-----------KVM---AVSFRS----------GHIFI 151

  Fly   119 QSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLS 183
            |:||..|.||||::||....|...|.:  ::.|.:||::.|...:.....:|...||:|....||
Zfish   152 QTDKPIYNPGDKVRFRAFVSDLEFRSS--ERTISLEIQNPDGIAVHGIGRVKAIDGVFSDIFSLS 214

  Fly   184 DRPVLGNWTVTATVQDEGKVTNV----LVVDKYVVPKFEVVVLTAK--NVAASAGYIRATIKARY 242
            .....|.|.|.|.. |:|| .||    ..|.|||:|.|. |.||.|  :::..|..:...|.|||
Zfish   215 TVVKEGRWKVVAKF-DQGK-ENVFSREFEVKKYVLPAFN-VTLTPKTSHLSLDAEKLEVEITARY 276

  Fly   243 TFKKPVKG--HVVATIEGSSTEQSL-------PIDG--------EVNVEFP-ISATAKRLLKITA 289
            .:...|||  :|:..||.:..::.|       .::|        |:...:| |::.....|.:.|
Zfish   277 LYGAQVKGVAYVLFGIEINGEKKRLTSMKQIDDLNGGSVSLTMEEIKRAYPDINSLLGSTLYVKA 341

  Fly   290 -IVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNF 353
             ::|...:|:.....:.:.:.:..:.|.....|.:|:||:......:|.|.||||..:....|.|
Zfish   342 SVLTSSGSDLVEAEKSGIKIVKSPYMLTIKDTPKYYKPGLPLAMTVIVSNHDGSPTPNIPVKVTF 406

  Fly   354 NVLCCQVSKNFSASLQNSIATE------HIMLPET-------------------------CQSCL 387
                          |::.|:..      ||.:|:|                         .|...
Zfish   407 --------------LESPISVHSGTINIHINMPKTHILYGNSQILKVETVDPSLKPEQQAIQEVY 457

  Fly   388 VT--STFDTAENI-------ERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVA 443
            |.  |||...:|.       .|.:...:..:.:.|.:..|..|.|::       :|.|.:|.
Zfish   458 VKPYSTFSGHDNFLHVSVGASRVVVGGSVSVQMYIKSSLPNHRALVE-------HLTYIVLN--- 512

  Fly   444 RGNIVLSLFQEMKEKKKSQEI---------EFEPTFALVPQATIFVHYIID----GVLMSDEKTV 495
            :|.|:    |..:...|.|::         |..|.|..|      .:|::.    ..:::|...|
Zfish   513 KGKII----QAGRVNVKGQDVTSVHLLITTEMLPAFRFV------AYYVLPWQHRAEVVADSVFV 567

  Fly   496 DIERDFENTI-------EILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDL 553
            |:|.....::       ||:::..  |......:||.:..:.|.|:.||.::.|| |.|.|.:..
Zfish   568 DVEDRCVGSLNVGPVDGEIVSSYS--PGSSFKFQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKK 629

  Fly   554 I----------------LNNLATYSTDLVILTNANINIYRSSGG--------------------- 581
            :                .:|:..:|       :|.:..:.|:||
Zfish   630 VWEVVDQADMGCTAGGGKDNMGVFS-------DAGLMFHSSTGGSTDSKEDCSSKTKRRRRSAAK 687

  Fly   582 --------------------------------CYTNP-----------GYTNCTGSLIGRTM-FK 602
                                            ||...           .:..|.....|..: ..
Zfish   688 LQLRDQLEKAYSDELLQRCCVDGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGEELGVI 752

  Fly   603 NEPTKNSGPVPIVGST--------------------------RAQASLPP--------------- 626
            ..|...:.|..|...|                          |...|:|.
Zfish   753 TRPPPTTAPPTIAPPTTSPPTLFLVPHLEYHFPEQPVFFVRDRVLQSMPKLHAEANVVGVRQDSY 817

  Fly   627 ---------------------------VRKLFPETWLFSNI---TDVGANG--EYIIKETVPDTL 659
                                       ||..|.|:||:::|   :...::|  .:.:...:||::
Zfish   818 REVVVEEEEEAASVFEEDDLSDLEDIYVRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSI 882

  Fly   660 TSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKV 724
            |.|.....|.||:.|:.|. .|..:||::||||...||:||.|.|.:.|..::.||....::..|
Zfish   883 TQWGFLAVSASPEKGVCVA-EPYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEVMV 946

  Fly   725 LMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAI-SKY 788
            :          :|.|....|....|..|:: :.:.|.:.:.|::.|.|.|.|...|::||: :.:
Zfish   947 I----------LEKTEDMCSVAYTGQHRQQ-VTVAAGSSKLITYTIIPLKTGELPLQVTAVAASF 1000

  Fly   789 AG-DRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEK-------TIIIEK--ADNVIEGS 843
            .| |.:.:.|:|..:|:|....::.::|          |.||       .|.::|  .|.|:..|
Zfish  1001 MGQDAVKKNLRVVVEGIQTLKVRSFVLN----------PSEKGGSAGQQLIQVKKMQLDAVVPKS 1055

  Fly   844 ETVEF-EVCGTSQAPQLEH------LDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEI- 900
            ....| .|.|...|..:::      |..|:.:|.||.|||:......::|..||  ....|.||
Zfish  1056 VPETFVNVRGDLLADSIDNSIKEDSLAALIRMPGGCVEQNLARITLPLIAAHYL--DRSADWEIV 1118

  Fly   901 ----ENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVL 961
                ..:|.:|::.||:.:||||::|.|:..:.....  |||:||||::.|..|..:|::::..|
Zfish  1119 GISRREEAIKYIQRGYENQLNYKKSDDSYPPYANEGT--STWITAYVVKVFSMAHSFINVNEKHL 1181

  Fly   962 VAGLDFLV-SRQSTDGKFKELGMVIHNS-----HGS--PLALTSFVLLTFFENEEYMPKYKHVID 1018
            ...|.:|: ::|..||.|:|...|...|     .||  ..:||:|||:...|.::.:......::
Zfish  1182 CGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIALAEAQDKVTCQDQEVN 1246

  Fly  1019 ------RAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWTGSDK 1077
                  :|..::.....:...||..|||..||:::.|.....:|     |.....||..|..|:.
Zfish  1247 IRDKSRQAAGYLTEHFSRLTRPYTAAIACYALAVSNNACVKSML-----LKFASPDHSHWPDSNN 1306

  Fly  1078 CKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHAS 1142
            ...: :|.|.|.||||::....:|.:....||...|...||:.|:|.|:|.:.||::|.::....
Zfish  1307 YFFT-LEATGYALLALIKSGHMEEAEAPFRWLNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPP 1370

  Fly  1143 TE-----------AIDIEFWHLNEDKKHV----RVTKENEFKVQT--------------HQLP-- 1176
            ::           ..|:. |..|.:..:|    ||..:.||.|..              ||||
Zfish  1371 SDLNLLVQLSVPGRSDVR-WTFNPNLAYVARSSRVPLDQEFSVAASGNGKGVLEVVTVYHQLPDV 1434

  Fly  1177 -ENT--NEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYTPIAA 1238
             ||:  |..:|        .|.:.......:.:...||:|...|:                  |.
Zfish  1435 YENSTCNGFQL--------DVSIAETNEKTSSDVEKSFRLNVNVR------------------AL 1473

  Fly  1239 SERNKTTNMALMQVQLPSGYVCDIEP-FADIEA--------ISDVKRVETKNEDTEVHIYFEKLS 1294
            .||.  ..|.::.:.||:|:    || .:|:|.        |::.:.|:..::...:.|:..|:|
Zfish  1474 EERQ--VRMVILDIGLPTGF----EPENSDLELLTNSVDRYINNFQVVDNLSDRGSLIIHLFKVS 1532

  Fly  1295 PGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY---HVDTSLCDICHGNEC----GN 1352
            ..:.:.::........|..|:||.|::|.||..::|.:.||   .....|..||.|:.|    |:
Zfish  1533 NKEAEMISFRLNQKFKVGLLQPSTVKVYQYYNKDKSCSRFYSPPEDKQQLDQICEGDVCRCSQGD 1597

  Fly  1353 MC 1354
            .|
Zfish  1598 CC 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	312/1392 (22%)
		A2M_2	859..1135	CDD:239227	86/300 (29%)
		A2M_recep	1243..1336	CDD:462226	24/104 (23%)
c3b.1	XP_009294664.1	MG1	43..143	CDD:465508	26/110 (24%)
		YfaS	<148..1498	CDD:441940	325/1463 (22%)
		A2M	852..948	CDD:459711	30/106 (28%)
		complement_C3_C4_C5	1079..1363	CDD:239226	86/293 (29%)
		A2M_recep	1480..1574	CDD:462226	23/97 (24%)
		NTR_like	1593..1766	CDD:470599	2/7 (29%)