DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep1 and c3b.1

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:XP_009294664.1 Gene:c3b.1 / 563665 ZFINID:ZDB-GENE-030131-2211 Length:1768 Species:Danio rerio


Alignment Length:1692 Identity:377/1692 - (22%)
Similarity:643/1692 - (38%) Gaps:498/1692 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSV-------SLTGPS-----LNS------------ 63
            :|:|||..:|..:..|::|..||..:..||:|       |.|..|     |||            
Zfish    46 FSLLAPAKIRPGTKQNILVEGHNLAQVVEVTVVVYDYPNSQTALSRGSVFLNSDNNYSVLQTLEI 110

  Fly    64 ----------RKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYI 118
                      :|||.:.:..|...|.:           |||   .:.|::          ..::|
Zfish   111 NPNLLLPDGKKKYVKLVAQFSNIYRAE-----------KVM---AVSFRS----------GHIFI 151

  Fly   119 QSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLS 183
            |:||..|.||||::||....|...|.:  ::.|.:||::.|...:.....:|...||:|....||
Zfish   152 QTDKPIYNPGDKVRFRAFVSDLEFRSS--ERTISLEIQNPDGIAVHGIGRVKAIDGVFSDIFSLS 214

  Fly   184 DRPVLGNWTVTATVQDEGKVTNV----LVVDKYVVPKFEVVVLTAK--NVAASAGYIRATIKARY 242
            .....|.|.|.|.. |:|| .||    ..|.|||:|.|. |.||.|  :::..|..:...|.|||
Zfish   215 TVVKEGRWKVVAKF-DQGK-ENVFSREFEVKKYVLPAFN-VTLTPKTSHLSLDAEKLEVEITARY 276

  Fly   243 TFKKPVKG--HVVATIEGSSTEQSL-------PIDG--------EVNVEFP-ISATAKRLLKITA 289
            .:...|||  :|:..||.:..::.|       .::|        |:...:| |::.....|.:.|
Zfish   277 LYGAQVKGVAYVLFGIEINGEKKRLTSMKQIDDLNGGSVSLTMEEIKRAYPDINSLLGSTLYVKA 341

  Fly   290 -IVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNF 353
             ::|...:|:.....:.:.:.:..:.|.....|.:|:||:......:|.|.||||..:....|.|
Zfish   342 SVLTSSGSDLVEAEKSGIKIVKSPYMLTIKDTPKYYKPGLPLAMTVIVSNHDGSPTPNIPVKVTF 406

  Fly   354 NVLCCQVSKNFSASLQNSIATE------HIMLPET-------------------------CQSCL 387
                          |::.|:..      ||.:|:|                         .|...
Zfish   407 --------------LESPISVHSGTINIHINMPKTHILYGNSQILKVETVDPSLKPEQQAIQEVY 457

  Fly   388 VT--STFDTAENI-------ERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVA 443
            |.  |||...:|.       .|.:...:..:.:.|.:..|..|.|::       :|.|.:|.   
Zfish   458 VKPYSTFSGHDNFLHVSVGASRVVVGGSVSVQMYIKSSLPNHRALVE-------HLTYIVLN--- 512

  Fly   444 RGNIVLSLFQEMKEKKKSQEI---------EFEPTFALVPQATIFVHYIID----GVLMSDEKTV 495
            :|.|:    |..:...|.|::         |..|.|..|      .:|::.    ..:::|...|
Zfish   513 KGKII----QAGRVNVKGQDVTSVHLLITTEMLPAFRFV------AYYVLPWQHRAEVVADSVFV 567

  Fly   496 DIERDFENTI-------EILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDL 553
            |:|.....::       ||:::..  |......:||.:..:.|.|:.||.::.|| |.|.|.:..
Zfish   568 DVEDRCVGSLNVGPVDGEIVSSYS--PGSSFKFQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKK 629

  Fly   554 I----------------LNNLATYSTDLVILTNANINIYRSSGG--------------------- 581
            :                .:|:..:|       :|.:..:.|:||                     
Zfish   630 VWEVVDQADMGCTAGGGKDNMGVFS-------DAGLMFHSSTGGSTDSKEDCSSKTKRRRRSAAK 687

  Fly   582 --------------------------------CYTNP-----------GYTNCTGSLIGRTM-FK 602
                                            ||...           .:..|.....|..: ..
Zfish   688 LQLRDQLEKAYSDELLQRCCVDGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGEELGVI 752

  Fly   603 NEPTKNSGPVPIVGST--------------------------RAQASLPP--------------- 626
            ..|...:.|..|...|                          |...|:|.               
Zfish   753 TRPPPTTAPPTIAPPTTSPPTLFLVPHLEYHFPEQPVFFVRDRVLQSMPKLHAEANVVGVRQDSY 817

  Fly   627 ---------------------------VRKLFPETWLFSNI---TDVGANG--EYIIKETVPDTL 659
                                       ||..|.|:||:::|   :...::|  .:.:...:||::
Zfish   818 REVVVEEEEEAASVFEEDDLSDLEDIYVRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSI 882

  Fly   660 TSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKV 724
            |.|.....|.||:.|:.|. .|..:||::||||...||:||.|.|.:.|..::.||....::..|
Zfish   883 TQWGFLAVSASPEKGVCVA-EPYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEVMV 946

  Fly   725 LMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAI-SKY 788
            :          :|.|....|....|..|:: :.:.|.:.:.|::.|.|.|.|...|::||: :.:
Zfish   947 I----------LEKTEDMCSVAYTGQHRQQ-VTVAAGSSKLITYTIIPLKTGELPLQVTAVAASF 1000

  Fly   789 AG-DRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEK-------TIIIEK--ADNVIEGS 843
            .| |.:.:.|:|..:|:|....::.::|          |.||       .|.::|  .|.|:..|
Zfish  1001 MGQDAVKKNLRVVVEGIQTLKVRSFVLN----------PSEKGGSAGQQLIQVKKMQLDAVVPKS 1055

  Fly   844 ETVEF-EVCGTSQAPQLEH------LDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEI- 900
            ....| .|.|...|..:::      |..|:.:|.||.|||:......::|..||  ....|.|| 
Zfish  1056 VPETFVNVRGDLLADSIDNSIKEDSLAALIRMPGGCVEQNLARITLPLIAAHYL--DRSADWEIV 1118

  Fly   901 ----ENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVL 961
                ..:|.:|::.||:.:||||::|.|:..:.....  |||:||||::.|..|..:|::::..|
Zfish  1119 GISRREEAIKYIQRGYENQLNYKKSDDSYPPYANEGT--STWITAYVVKVFSMAHSFINVNEKHL 1181

  Fly   962 VAGLDFLV-SRQSTDGKFKELGMVIHNS-----HGS--PLALTSFVLLTFFENEEYMPKYKHVID 1018
            ...|.:|: ::|..||.|:|...|...|     .||  ..:||:|||:...|.::.:......::
Zfish  1182 CGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIALAEAQDKVTCQDQEVN 1246

  Fly  1019 ------RAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWTGSDK 1077
                  :|..::.....:...||..|||..||:::.|.....:|     |.....||..|..|:.
Zfish  1247 IRDKSRQAAGYLTEHFSRLTRPYTAAIACYALAVSNNACVKSML-----LKFASPDHSHWPDSNN 1306

  Fly  1078 CKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHAS 1142
            ...: :|.|.|.||||::....:|.:....||...|...||:.|:|.|:|.:.||::|.::....
Zfish  1307 YFFT-LEATGYALLALIKSGHMEEAEAPFRWLNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPP 1370

  Fly  1143 TE-----------AIDIEFWHLNEDKKHV----RVTKENEFKVQT--------------HQLP-- 1176
            ::           ..|:. |..|.:..:|    ||..:.||.|..              ||||  
Zfish  1371 SDLNLLVQLSVPGRSDVR-WTFNPNLAYVARSSRVPLDQEFSVAASGNGKGVLEVVTVYHQLPDV 1434

  Fly  1177 -ENT--NEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYTPIAA 1238
             ||:  |..:|        .|.:.......:.:...||:|...|:                  |.
Zfish  1435 YENSTCNGFQL--------DVSIAETNEKTSSDVEKSFRLNVNVR------------------AL 1473

  Fly  1239 SERNKTTNMALMQVQLPSGYVCDIEP-FADIEA--------ISDVKRVETKNEDTEVHIYFEKLS 1294
            .||.  ..|.::.:.||:|:    || .:|:|.        |::.:.|:..::...:.|:..|:|
Zfish  1474 EERQ--VRMVILDIGLPTGF----EPENSDLELLTNSVDRYINNFQVVDNLSDRGSLIIHLFKVS 1532

  Fly  1295 PGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY---HVDTSLCDICHGNEC----GN 1352
            ..:.:.::........|..|:||.|::|.||..::|.:.||   .....|..||.|:.|    |:
Zfish  1533 NKEAEMISFRLNQKFKVGLLQPSTVKVYQYYNKDKSCSRFYSPPEDKQQLDQICEGDVCRCSQGD 1597

  Fly  1353 MC 1354
            .|
Zfish  1598 CC 1599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 28/84 (33%)
A2M_N_2 411..542 CDD:285005 30/150 (20%)
A2M 634..726 CDD:278630 30/96 (31%)
A2M_2 859..1135 CDD:239227 86/300 (29%)
A2M_comp 910..1135 CDD:284982 70/238 (29%)
A2M_recep 1245..1335 CDD:284981 22/98 (22%)
c3b.1XP_009294664.1 A2M_N 149..242 CDD:280081 32/96 (33%)
A2M_N_2 500..619 CDD:285005 28/140 (20%)
ANATO 691..747 CDD:237984 3/55 (5%)
A2M 852..948 CDD:278630 30/106 (28%)
TRAPPC10 <939..>991 CDD:289361 12/62 (19%)
complement_C3_C4_C5 1079..1363 CDD:239226 86/293 (29%)
A2M_comp 1133..1363 CDD:284982 70/237 (30%)
A2M_recep 1480..1573 CDD:284981 22/96 (23%)
NTR_like 1593..1766 CDD:295338 2/7 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584208
Domainoid 1 1.000 48 1.000 Domainoid score I11904
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
76.800

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