DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and c3a.6

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001008582.4	Gene:	c3a.6 / 494039	ZFINID:	ZDB-GENE-041212-2	Length:	1642	Species:	Danio rerio

Alignment Length:	1584	Identity:	361/1584 - (22%)
Similarity:	645/1584 - (40%)	Gaps:	335/1584 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVV--------------AIHNTTR-TTEV- 52
            |.||:.:|...||:..:.||.:.||..||..|:.||.|              ::.|..| ..|:
Zfish     6 LFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQDYSGGSLIVKISVKNHPRKNLEIL 70

  Fly    53 --SVSLTGPSLNSRKYVDVQSMSSKSVRFDIPKLTEGDY------------ELKVMGSGGIEFQN 103
              :|:||..: |.:...|::..|.:....|.|  .|..|            |..||    :.||:
Zfish    71 SKTVTLTDEN-NFQILADIKIPSDRDYFSDDP--LEKQYVYLQAQFPTHTLEKVVM----LSFQS 128

  Fly   104 STKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKD 168
                      .::::|:||..|.||..:|:|:..|....:| :.:..:.:||.| .|.:....:.
Zfish   129 ----------GYIFVQTDKPIYTPGSNVQYRIFSLTSGLKP-LENAGVSVEIMD-PQGITTMRET 181

  Fly   169 IKPAKGVYSGELQLSDRPVLGNWTVTA--TVQDEGKVTNVLVVDKYVVPKFEVVVLTAKN-VAAS 230
            |.|.:|:.||:..:......|.|.|..  |...:...|....|..||:|.:||.:..:|: .:..
Zfish   182 IFPKQGIRSGKYMVPQPASPGIWKVVTRFTNTPQKNYTADFEVKDYVLPTYEVTLSPSKSFFSVK 246

  Fly   231 AGYIRATIKARYTFKKPVKGH--VVATIEGSSTEQSLP--------IDGEVNVE---------FP 276
            ...:..:|:|||.....|.||  ||..:.....:.|:|        .|||.|.:         ||
Zfish   247 DDSLTVSIEARYLHGNNVNGHAFVVFGVMEDDRKTSIPSSLQRVQISDGEGNAKLTKQTILQTFP 311

  Fly   277 -ISATAKRLLKIT-AIVTE---ELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVV 336
             ||....|.:.|: :::|:   ||.:.:..|...||   ..:.:.....|..::||:.......:
Zfish   312 DISQLVGRSIYISVSVLTDSGSELVEAQRRGIQIVT---SPYTINFQKTPQFFKPGMPFSVSVYI 373

  Fly   337 RNLDGSPVMDSSKMVNFNVLCCQVSKN-----------FSASLQNSIATEHIMLPETCQSC--LV 388
            .:.:..|..:...:||...:..|...|           .|::|:.::.|:.....:..|:.  :|
Zfish   374 TDPNQMPAENVEVLVNPGGVKGQTKSNGIAKLTVNSIEGSSALEITVQTKDPKFDDDQQALKKMV 438

  Fly   389 TSTFDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINI-------ISDTYLPYFILTVVARGN 446
            ...:.|..:.:.|::       |.|:..:.::...:|:|:       :.|....|.||   ::|.
Zfish   439 PQAYKTKGSSQNYLH-------IGIDAAEFEIGDQMKVNLNLGKSPGVRDQDFTYMIL---SKGQ 493

  Fly   447 IVLSLFQEMKEKKKSQEI---------EFEPTFALVPQATIFVHYIIDGVLMSDEKTVDIERDFE 502
            ||    |..:.|::.|.:         |..|:|..|.     .:::....::||...||::....
Zfish   494 IV----QADRFKRQGQALVTLSLPVTKEMVPSFRFVA-----YYHVGSSEVVSDSVWVDVKDTCM 549

  Fly   503 NTIEILTTNEA---LPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNR-------DLI--- 554
            .|:::......   .|.:|.||.:..:|.:.|||:.||::|    .|.:.||       |::
Zfish   550 GTLKVQVKEPRPIYQPGEEFSLLITGDPGAKVGLVAVDKAV----HGLNQNRLTQTKIWDIVEKH 610

  Fly   555 ---------------------------------------------------LNNLAT-----YST 563
                                                               |..:.|     ||.
Zfish   611 DTGCTAGGGRDSMGVFIDAGLMFESHTAGGTESRTVPECVIPSKRRRRAESLQKITTILAGQYSG 675

  Fly   564 DLVILTNANINIYRSSGGC-----YTNPG------YTNCTGSLIGRTMFKNEPTKNSGPVPIVGS 617
            ||.......:...:....|     |.:.|      :.:|...::.|::       .:|...::.:
Zfish   676 DLRKCCVDGMRDNKLGYTCERRATYVSDGVECVRAFLHCCNDVVSRSL-------EAGEEEMILA 733

  Fly   618 TRAQA----SLPPV--RKLFPETWLFS-NITDVGANGEYIIKETV--PDTLTSWVITGFSLSPQS 673
            ...::    |...:  |..|||:||:| .|..|.:....:.|..:  .:::|:|.|...|||...
Zfish   734 RSEESDYYESFEEITSRTQFPESWLWSEEILPVCSATTSVTKSRIYLKESITTWQIFAVSLSKTH 798

  Fly   674 GLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIET 738
            |:.|. :|..:.|::.|||...:|:|..|.|.:.:..|:.||....:||::         ||.||
Zfish   799 GICVA-DPHEMIVYKMFFIDLKVPFSAVRNEQLQVRAILHNYTKKKIKARL---------EFKET 853

  Fly   739 TN-----KNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVG--LTTLKITAISKYAGDRLHQI 796
            .:     .|...|...|.      :.:.:.|.|..:|.|.::|  ...:|..|......|.:.:|
Zfish   854 KHICSSASNKGSYQTEVE------VESMSSRTIPHVIIPLELGNHWIEVKAAAFDSVYSDGVKKI 912

  Fly   797 LKVEADGVQKYV-------NKAVLINVQRLNRRSLAPPEKTIIIEKADNVI-----EGSETVEFE 849
            |||.::||...|       |.|.:..:|.::.|| ..|:..:....|:..|     :.|:|:|..
Zfish   913 LKVVSEGVLTMVQETNVELNPAKIGGLQEVSVRS-GKPDTRVPNTPANTYISVTGKDFSKTIEQP 976

  Fly   850 VCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQD---QEIENKAKRYVETG 911
            :.|       |.:...:..|.|.||:||......::|..||...|:.|   ....|:|..:::||
Zfish   977 IGG-------EVMKQFIVQPRGTGEENMIYMTFPVIATHYLDITNQWDTVGMNRRNEAINHIKTG 1034

  Fly   912 YQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFL-VSRQSTD 975
            ||.:|.:::.||||:|  ......||||||||.:....|:....:|::|:.:.|.:| .::|.:|
Zfish  1035 YQRQLTFRKPDGSFAA--LMTTPSSTWLTAYVAKVLTIASDLTVVDESVICSALQWLAANKQLSD 1097

  Fly   976 GKFKELGMVIH-------NSHGSPLALTSFVLLTFFENEEYMPK----YKHVIDRAVEFVVTEVH 1029
            |.|||...::|       ....:..:||:|||:...|..:...|    .:..:::||.::...:|
Zfish  1098 GMFKEDSHILHEEMQGAVRGKDADASLTAFVLIAMQEGSQICAKSVQNLQSSMNKAVGYLTLRIH 1162

  Fly  1030 QSNEPYDLAIAALALSLARNRNAYKVLDK--LDKLATRRGDHKWWTGSDKCKSSEVETTSYVLLA 1092
            ....||.:||::.||:.|..      |:|  |.:.:|:.....:|........| :|.|.|.:||
Zfish  1163 TLTSPYAVAISSYALAHAGK------LEKGILKRHSTQNDAGSFWRVPGALHLS-LEATGYAVLA 1220

  Fly  1093 LLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEF------- 1150
            |::..........|.||.::|.:.|...::|.:::...|:.:|...:......:||:.
Zfish  1221 LVKEQDFQSAGSAVRWLRAQRAAYGAHGTTQASLIVFQAVAEYRTGAKKQDVNLDIQLSVEGRKT 1285

  Fly  1151 ---WHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPS-- 1210
               |..:....|  ||:.::.     ||.:..|   :.|.|.|.|.:.: |....|..|.|.:
Zfish  1286 QNKWTFSRSNSH--VTRSDKV-----QLAQGFN---VTAHGNGLATLSV-YSLYYALPEERENDC 1339

  Fly  1211 --FKLTTTVKK----SHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIE 1269
              |:|:..:.|    ||.|.:...:....|...:|||:..  |:::.|.|.:|:..|....:.:.
Zfish  1340 KVFELSVQMDKQLEVSHPGAIESYLLTIETHFRSSERDAA--MSVLDVGLLTGFKVDDGDLSKLA 1402

  Fly  1270 AISD--VKRVETKNE--DTE-VHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATER 1329
            ...|  :.|.|...|  |.| :.|...|:|...|..:.......:.|..|:|:.|.:|:|...:.
Zfish  1403 KGKDRYIDRFEMNKELSDRESLVIILNKVSHKVRDRVAFRVHKVNEVGMLQPAGVTVYEYNTPDD 1467

  Fly  1330 SATEFYHV---DTSLCDICHGNEC 1350
            ...:|||.   |.:|..:||.:.|
Zfish  1468 RCVKFYHPHKRDGALNRLCHEDLC 1491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	23/86 (27%)
		A2M_N_2	411..542	CDD:285005	34/149 (23%)
		A2M	634..726	CDD:278630	28/94 (30%)
		A2M_2	859..1135	CDD:239227	80/292 (27%)
		A2M_comp	910..1135	CDD:284982	66/238 (28%)
		A2M_recep	1245..1335	CDD:284981	21/94 (22%)
c3a.6	NP_001008582.4	A2M_N	130..224	CDD:280081	24/95 (25%)
		A2M_N_2	454..590	CDD:285005	33/147 (22%)
		ANATO	669..733	CDD:237984	10/70 (14%)
		A2M	756..849	CDD:278630	28/102 (27%)
		complement_C3_C4_C5	979..1263	CDD:239226	81/299 (27%)
		A2M_comp	1033..1263	CDD:284982	66/238 (28%)
		A2M_recep	1380..1473	CDD:284981	21/92 (23%)
		NTR_complement_C3	1493..1640	CDD:239638
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584192
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940