DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and Cd109

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001102241.2	Gene:	Cd109 / 363104	RGDID:	1311287	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1397	Identity:	401/1397 - (28%)
Similarity:	661/1397 - (47%)	Gaps:	220/1397 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YELKVMGSGGIE--FQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPI 151
            |||.:.|....|  |.|.|:|:|......::||:||..|||..:::||||.|..:.:|  ...|:
  Rat   101 YELHISGKSETEIVFSNRTRLTFDSKRISVFIQTDKVIYKPKQEVKFRVLTLFSDLKP--YKTPV 163

  Fly   152 KIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPK 216
            .|.|:|...|||:.|...:...||.|...|||..|:||:|::...|.|:....:..|:| ||:||
  Rat   164 DIYIKDPKSNLIQQWLSQEGELGVVSKTFQLSSHPILGDWSIQVQVIDQLYYQSFQVLD-YVLPK 227

  Fly   217 FEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATI-------EGSSTEQSLPIDGEVNVE 274
            |||.:.|....:..|.|:|..:.|:||:.|||||.:..|.       :..:..::..|:|..|..
  Rat   228 FEVTLQTPLYCSLKAKYLRGNVTAKYTYGKPVKGSLSLTFIPLSFWGKKKNITKNFEINGFTNFA 292

  Fly   275 FPISATAKRL-----------------------LKITAIVTEELTDIKHNGTAYVTVHQHRHKLE 316
            |......|.:                       ::|.|.|||.||......:..|...||.:.:|
  Rat   293 FDADEMKKVMNLKKATEISDGNYDQVDPVFPGPVEIVATVTESLTGTSRKASTNVFFKQHDYVIE 357

  Fly   317 DLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPE 381
            ...:.|..:|.::......:...||.. :...:|.|..|......||.:.:.:.:..|::|.:.|
  Rat   358 IFDYTTVLKPTLNFTATVKISRSDGKQ-LTPEEMENDLVTVVTQKKNDNPTREKAQGTDYIQMTE 421

  Fly   382 TCQSCLVTSTFDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINII---------------SD 431
                      :....|   .:.|:..|:|    :...:|:  ||.:.:               |:
  Rat   422 ----------YSVPHN---GVVKVEFPIM----SDSSELQ--LKASFLDSASSVAVHSVFTSPSN 467

  Fly   432 TYLPYFI----LTVVARGNIVLSLFQEMKE---------------KKKSQEIEFEPTFALVPQAT 477
            ||:....    :||.:..|:.:|..|:.||               |:.|:.....|..:..|:|.
  Rat   468 TYIQLKTRDEHITVGSPFNLTVSGNQKFKEISYMVISKGQLVAVGKQSSRTFSLTPEASWAPKAC 532

  Fly   478 IFVHYI-IDGVLMSDEKTVDIERDFENTIEILTTNEAL-PRDEVSLKVK-TNPHSFVGLLGVDQS 539
            |.|:|| .||.::||...:.::.||:|.|::..:...: |.|:|||::. |..:|.||::.||:|
  Rat   533 IIVYYIEQDGEVISDILKIPVQLDFKNKIKLSWSKPRVKPSDKVSLRISVTQSYSLVGIVAVDKS 597

  Fly   540 VLLLRSGNDLNRDLILNNLATYSTD-----------------LVILTNANINIYRSSGGCYTNPG 587
            |.|:.:.||:..:.:::.|..|:|:                 |.:||:||: :..:....|....
  Rat   598 VKLIGNSNDITMENVVHELELYNTEYYLGMFLNSFAVFQECGLWVLTDANL-VRDNIDEVYDTQE 661

  Fly   588 YTNCTGSLIGRTMFKNEPTKNSGPVPIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIK 652
            |:.         .|..|...|.    :.....:.||...|||.|||:|::.:.. :|:......:
  Rat   662 YSE---------RFAEENEANL----VDFEDTSSASNSHVRKHFPESWIWLDFY-MGSKNHEEYE 712

  Fly   653 ETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLG 717
            .||||::||||.:.|.:|...|..:|..|:.:..||||||:.||||||.|||..|:.|.:.|||.
  Rat   713 VTVPDSITSWVASAFVISEDLGFGLTATPAELHAFQPFFISLNLPYSVIRGEEFALEVSIVNYLK 777

  Fly   718 MDVKAKVLMDNSDGQYEFIETTNK-NVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLK 781
            ...|..||::.|| .::.:..:|. |.:.|      :||..:|......:.|.|:|..:|...:.
  Rat   778 DTTKVVVLIEESD-SFDILMFSNDINNTIY------RKTALVPRENSVTLVFPIKPTHLGNVPIT 835

  Fly   782 ITAISKYAGDRLHQILKVEADGVQKYVNKAVLINV----QRLNRRSLA---PPEKTIIIEKADNV 839
            :||.|..:.|.:.:.:.|:.:||.|..:::||:.:    |:...:||:   ||:          .
  Rat   836 VTAASPTSSDVVTRTIVVKPEGVAKSYSQSVLLELIDKKQQTEPKSLSFSFPPD----------T 890

  Fly   840 IEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKA 904
            |.|||.::....|......:..|..|:.||.|||||||....|::..|.||..:.:....::.||
  Rat   891 ISGSERIQITAIGDILGSSINGLSSLIRLPYGCGEQNMVYLAPNVYILDYLTKQKQLTVNLKEKA 955

  Fly   905 KRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLV 969
            ..::..|||.||.|:|.||||||:|..|:.|||||:|:|:|.|.:||:|||||::||.....:|.
  Rat   956 LSFMRQGYQRELLYQREDGSFSAFGNSDSSGSTWLSAFVLRCFMEAAQYIDIDQDVLHRTYSWLE 1020

  Fly   970 SRQSTDGKFKELGMVIH----NSHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQ 1030
            :.:.|:|:|.|.|.|||    ..:.||:.||::|:.:....::|.|..:  |..:::|:..|.::
  Rat  1021 AHKKTNGEFWEPGRVIHIELQGGNKSPITLTAYVVTSLLGYKKYQPNIE--IQDSIKFLENEFNR 1083

  Fly  1031 S-NEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWTGSD-------KCKSSEVETTS 1087
            . ::.|.||:...|||...:..|.:.|..|.:.|.:.||.::|..|.       :..|:::|..:
  Rat  1084 GISDNYTLALVTYALSAVGSPKAEEALTMLTQQAEKEGDTQFWLSSTSESSESWQSLSAQIEIAA 1148

  Fly  1088 YVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAID----- 1147
            |.|||..:|:: .|..||:.|||.:|||.|||||:||||:.:.||:::....:.....:.
  Rat  1149 YALLAHTQHHV-PEGIPIMKWLIKQRNSLGGFVSTQDTVMALKALSEFSALVYKENRDMQVTIKG 1212

  Fly  1148 ------IEFWHLNEDKKHVRVTKENEFKVQTHQL-PENTNEVKLLAKGQGRAQVQLTYRYNVATK 1205
                  |.||          :..:|.||:...:| |.:...|.:.|.|.|.|..||...|||
  Rat  1213 PNVPKPIRFW----------IDSQNLFKLHKEELAPLDPIAVNVSAHGSGFAICQLNVDYNV--- 1264

  Fly  1206 EARPSFK------------LTTTVKKSHKGRLI-LGICGTYTPIAASERNKTTNMALMQVQLPSG 1257
            :|..|||            |...|...|..|.: |.:|.::....      .|.|||::|.|.||
  Rat  1265 KASSSFKRRRSMENPIGFDLDVDVNDEHDLRYMKLNVCTSHLGPG------RTGMALLEVNLLSG 1323

  Fly  1258 YVC--DIEPFADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVR 1320
            :..  |..|.::|     :|:||  .|..::::|.:.::. .:.|:.:..:....|:|::...|.
  Rat  1324 FTATSDSIPLSEI-----LKKVE--YEPGKLNLYLDHVNE-TQFCVKIPTVRDFKVSNIRDGLVS 1380

  Fly  1321 LYDYYATERSATEFYHVDTSL--CDICHGNEC 1350
            :.|||...|.|...|:....|  |.:.....|
  Rat  1381 IVDYYEPSRQAVRSYNTQMKLSSCYLSADPNC 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	33/84 (39%)
		A2M_N_2	411..542	CDD:285005	43/167 (26%)
		A2M	634..726	CDD:278630	37/91 (41%)
		A2M_2	859..1135	CDD:239227	110/287 (38%)
		A2M_comp	910..1135	CDD:284982	93/236 (39%)
		A2M_recep	1245..1335	CDD:284981	25/91 (27%)
Cd109	NP_001102241.2	YfaS	<122..>1019	CDD:225248	275/951 (29%)
		A2M_N_2	470..601	CDD:400170	37/130 (28%)
		A2M	695..784	CDD:395153	36/89 (40%)
		A2M_2	909..1195	CDD:239227	110/288 (38%)
		A2M_recep	1311..1395	CDD:400149	25/91 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343854
Domainoid	1	1.000	229	1.000	Domainoid score	I2388
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1022
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm44434
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910