DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and C5

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_444179.1	Gene:	C5 / 362119	RGDID:	2237	Length:	1688	Species:	Rattus norvegicus

Alignment Length:	1617	Identity:	383/1617 - (23%)
Similarity:	633/1617 - (39%)	Gaps:	358/1617 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LWLILSSTILHCVLLS-----NANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTG-PS 60
            ||.:|      |:|:.     .....|.:.|||..|..|:.|||:..|..|...:.::||.. |.
  Rat     8 LWGLL------CLLIFLDKTWGQEQTYVISAPKIFRVGSSENVVIQAHGYTEAFDATISLKSYPD 66

  Fly    61 LN---SRKYVDV--QSMSSKSVRFDI-PKLTEGDYE------LKVMGSGGIEFQNSTKLSFAPDL 113
            ..   |..||::  ::....|....: ||....|..      |:|:   .:.|..|.|:....|.
  Rat    67 KKVTYSSGYVNLSPENKFQNSALLTLPPKQFPRDENPVSHVYLEVV---SMHFSKSKKIPITYDN 128

  Fly   114 NWLYIQSDKATYKPGDKIQFRVLFLDKNTRPA--------VIDKPIKIEI-RDGDQNLIKSWKDI 169
            .:|:|.:||..|.|...::.||..|..:.:||        |..:..:::| .:.|...|.|:.|.
  Rat   129 GFLFIHTDKPVYTPDQSVKIRVYSLSDDLKPAKRETVLTFVDPEGTEVDIVEENDYTGIISFPDF 193

  Fly   170 KPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNV--LVVDKYVVPKFEVVVLTAKNVAASAG 232
            |           :...|..|.||:.|..:.:...|..  ..|.:||:|:|.|.:....|.   .|
  Rat   194 K-----------IPSNPKYGVWTIKAKYKKDFTTTGTAYFEVKEYVLPRFSVSIEPESNF---IG 244

  Fly   233 Y-----IRATIKARYTFKKPVKGHVVATIEG--------------SSTEQSLPIDGEVNVEFPIS 278
            |     ...|:||||.:.|.|....|....|              .:.:.:..::|...:.|...
  Rat   245 YKNFKNFEITVKARYFYNKMVPDAEVYIFFGLREDIKEDEKQMMHKAMQAATLVNGVAQISFDSE 309

  Fly   279 ATAKRL------------LKITAIVTE---------ELTDIKHNGTAYVTVHQHRHKLEDLFWPT 322
            ...|.|            |.|...|||         |:..||:..:.|.        |..:..|.
  Rat   310 TAVKELSYESLEDLNNKYLYIAVTVTESSGGFSEEAEIPGIKYVLSPYT--------LNLVATPL 366

  Fly   323 HYRPGVSSEFKTVVRN-----LDGSPVMDSSKMVNFNVLCCQVSKNFS----------------- 365
            ..:||:....|..|::     :.|.||...::.||.|.....:....|
  Rat   367 FLKPGIPFSIKVQVKDSLEQLVGGVPVTLMAQTVNVNQETSDLEPKRSITHSADGVASFVVNLPS 431

  Fly   366 --ASLQNSIATEHIMLPETCQSCLVTSTFDTAENIERYIY----KLNKPLM------IAINTKKP 418
              .||:..:.|:...|||..|:.........:...:.|||    :..||::      |.:..|.|
  Rat   432 EVTSLKFEVKTDAPELPEENQASKEYEAVTYSSLSQSYIYIGWTENYKPMLVGEYLNIIVTPKSP 496

  Fly   419 QLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYI 483
            .:.|:        |:..|.||   ::|.||....:|.......|.|....|..:||.|.:.|:||
  Rat   497 YIDKI--------THYNYLIL---SKGKIVQYGTKEKLLYSSYQNINIPVTQDMVPSARLLVYYI 550

  Fly   484 IDG----VLMSDEKTVDIERDFENTIEI-LTTNEAL--PRDEVSLKVKTNPHSFVGLLGVDQSVL 541
            :.|    .|::|...::||....|.::: |:.::.:  |...|||.:.|...|:|.|..||.:|.
  Rat   551 VTGEQTAELVADAVWINIEEKCGNQLQVHLSPDKDVYSPGQTVSLDMVTEADSWVALSAVDSAVY 615

  Fly   542 LLR-------------------------SGNDLNRDLILNNLATYSTDLVILTNANIN------- 574
            .:|                         .|.| |.|:.      :...|..|||||.:
  Rat   616 GVRGKAKRAMQRVFQAFDDKSDLGCGAGGGRD-NVDVF------HLAGLTFLTNANADDSQYHDD 673

  Fly   575 ----IYRSSGG-----------------------CYTNP---GYTNCTGSL----IGRTMFK--N 603
                |.|....                       ||...   .|..|...:    ||....:  |
  Rat   674 SCKEILRPKRDLQLLHQKVEEQAAKYKHRVPKKCCYDGARENKYETCEQRVARVTIGPHCIRAFN 738

  Fly   604 E----------PTKNSGPVPIVGSTRAQASLP----PVRKLFPETWLFSNITDVGANGEYIIKET 654
            |          .:.:.|  .::|..:.:|.||    .:|..|||:||: .:..|....:  ::..
  Rat   739 ECCTIADKIRKESHHKG--MLLGRIQIKALLPVMKAEIRSYFPESWLW-EVHRVPKRNQ--LQVA 798

  Fly   655 VPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMD 719
            :||:||:|.|.|..:| .:|:.|. :..:.:||:..|:..|:||||.|||.|.:...|:||....
  Rat   799 LPDSLTTWEIQGIGIS-DNGICVA-DTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSG 861

  Fly   720 VKAKVLMDNSDGQYEFIET-----TNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTT 779
            ....|.|...:|    |.|     .:...|:..|.||::    |..::...::|.:.|.::||.:
  Rat   862 TMFCVKMSAVEG----ICTPGSSAASPQTSRSSRCVRQR----IEGSSSHLVTFSLLPLEIGLHS 918

  Fly   780 LKITAISKYAGDRLHQILKVEADGVQKYVNKAVLINVQR----LNRRSLAPPEKTIIIEKADNV- 839
            :..:..:.:..:.|.:.|:|..:|:::.....|.::.:.    :|||...|....:.:....||
  Rat   919 INFSLETSFGKEILVKTLRVVPEGIKRESYAGVTLDPRGVYGIVNRRKEFPYRIPLDLVPKTNVK 983

  Fly   840 ----IEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNR----- 895
                ::|....||    .|.....|.:|.|.|||.|..|..:.:.||......||:|.|.
  Rat   984 RILSVKGLLIGEF----LSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNHWNIFH 1044

  Fly   896 -----QDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYID 955
                 :.|.::.|.|.    |....::|:..|.|:|.|  ..|..|.||||:.:|...|..||:.
  Rat  1045 PDTLARKQSLQKKIKE----GLVSVMSYRNADYSYSMW--KGASSSAWLTAFALRVLGQVNKYVK 1103

  Fly   956 IDKNVLVAGLDFLVSR-QSTDGKFKELGMVIHNSHGSPLALTSFVLLTFFENEEYMPKYKHV--- 1016
            .|:..:...|.:|:.: |..:|.|||      ||...|:.|...:.....||..|:..:..:
  Rat  1104 QDQYSICNSLLWLIEKCQLENGSFKE------NSQYLPIKLQGTLPAEAQENTLYLTAFSVIGIR 1162

  Fly  1017 --------------IDRAVEFVVTEVHQSNEPYDLAIAALALSLA-RNRNAYK-VLDKLDKLATR 1065
                          :.:|..|::.....|...:.|||.|.||||. |....:: ::..|.:.|..
  Rat  1163 KAIGICPTEKIYTALAKADSFLLERTLPSKSTFTLAIVAYALSLGDRTHPKFRSIVSALKREALV 1227

  Fly  1066 RGD---HKWW---------TGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGG 1118
            :||   :::|         :..:...:..||||:|.||..|....:....||:.||..::...||
  Rat  1228 KGDPPIYRFWRDTLQRPDSSAPNSGTAGMVETTAYALLTSLNLKETSYVNPIIKWLSEEQRYGGG 1292

  Fly  1119 FVSSQDTVVGIMALTKYEL---QSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTN 1180
            |.|:|||:..|..||:|.|   |.|...: |::.:.| ..|....:||::| |..:..::|.|.:
  Rat  1293 FYSTQDTINAIEGLTEYSLLVKQLHLDMD-INVSYKH-KGDFYQYKVTEKN-FLGRPVEVPLNDD 1354

  Fly  1181 EVKLLAKGQGRAQVQL-TYRYNVATKEARPSFKL---TTTVKKS---------HKGRLILGICGT 1232
            .:.......|.|.|.: |..:..:..|...||.|   |..|:.|         || |:|  .|.:
  Rat  1355 LIVTTGYSSGLATVYVKTVVHKTSVAEEFCSFYLKIDTQEVEASSYLSYSDSGHK-RII--ACAS 1416

  Fly  1233 YTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAI---SDVKRVETKNEDTEVHIYFEKLS 1294
            |.| :..|....::.|:|.:.||:|...:.|   |:.|:   .|....:.:.:|:.|.:....:.
  Rat  1417 YKP-SKEESASGSSHAVMDILLPTGIGANQE---DLRALVEGVDQLLTDYQIKDSHVILQLNSIP 1477

  Fly  1295 PGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHV-DTSLCDICHGNEC 1350
            ..|..|:.........|..|.|:...:|:|:..::..|..|.. ||:|..:|.|..|
  Rat  1478 SRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAAC 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	23/93 (25%)
		A2M_N_2	411..542	CDD:285005	39/137 (28%)
		A2M	634..726	CDD:278630	29/91 (32%)
		A2M_2	859..1135	CDD:239227	87/317 (27%)
		A2M_comp	910..1135	CDD:284982	70/256 (27%)
		A2M_recep	1245..1335	CDD:284981	19/92 (21%)
C5	NP_444179.1	MG1	25..125	CDD:375333	26/102 (25%)
		A2M_N	131..224	CDD:376626	24/103 (23%)
		MG3	226..310	CDD:375334	19/86 (22%)
		MG4	359..462	CDD:375332	20/102 (20%)
		A2M_N_2	475..615	CDD:377903	40/150 (27%)
		ANATO	691..759	CDD:237984	9/69 (13%)
		A2M	781..868	CDD:365945	29/91 (32%)
		complement_C3_C4_C5	1004..1309	CDD:239226	87/316 (28%)
		A2M_recep	1428..1518	CDD:369460	19/92 (21%)
		NTR_like	1536..1685	CDD:382999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940