DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and Tep4

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster

Alignment Length:	1532	Identity:	527/1532 - (34%)
Similarity:	781/1532 - (50%)	Gaps:	235/1532 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CVLLS--------NANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDV 69
            ||:|:        .|.|.|:::.|.|:.|:..|||.||:|.|.....:.|.:||||.|..:.|::
  Fly    12 CVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVEL 76

  Fly    70 QSMSS-KSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQF 133
            .:... |.:.|.:|.|..|:|.|...|..|:||:|||||::.....::.||:||..|||||.|.:
  Fly    77 ATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINY 141

  Fly   134 RVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQ 198
            ||:|||:|.||......:.:...|..:|.||..|.||...|||:|:.:||:...||:|::.....
  Fly   142 RVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNG 206

  Fly   199 D---EGKV-----------------TNVLV---VDKYVVPKFEVVVLTAKNVAASAGYIRATIKA 240
            |   :|.:                 ::.||   |:|||:||:.|.:...:.|:...|.....:||
  Fly   207 DQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKA 271

  Fly   241 RYTFKKPVKGHVVATIEGSSTEQSLPIDGE-VNVEFP----------ISATAKRLL--------- 285
            .||:.|||.|.|:..:...||.....:||: |..::|          :...||..:
  Fly   272 NYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYL 336

  Fly   286 ---------KITAIVTEELTDIKHNGTAYVTVHQHRHKLE--DLFWPTHYRPGVSSEFKTVVRNL 339
                     :|||.|.|:.|.:|.|.|..|.::.:|:::.  |......::|....|....:..:
  Fly   337 PHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYV 401

  Fly   340 DGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIA-----TEH----------------------- 376
            |||.:.|:..:         |...|:..::.:.|     |:|
  Fly   402 DGSLITDTKSV---------VKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASG 457

  Fly   377 -----IMLPETCQSCLVTSTFDTAENIERY----------------IYKLNKPLMI--------- 411
                 ::||:          .....|..||                .|...:|..|
  Fly   458 VAPFKVVLPD----------LPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEK 512

  Fly   412 ---AINTKKPQLRKLLKIN------IISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFE 467
               ....::|:....|||.      :.|...|.||:..:|.||||:.:...::.|.:.:..:..:
  Fly   513 EWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIK 577

  Fly   468 PTFALVPQATIFVHYIID-GVLMSDEKTVDIERDFENTIEILTTNEALPRDEVSLKVKTNPHSFV 531
            |||...|...::.:|:.: |.....|:|..:|.:.:|.|||....|..|..:|:|::||:|.|||
  Fly   578 PTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFV 642

  Fly   532 GLLGVDQSVLLLRSGNDLNRDLI---LNNLAT-------YS------TDLVILTNANINIYRSSG 580
            |||.||||||||.|.||||::..   ||...|       ||      |.:|.:|||.....|
  Fly   643 GLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNR--- 704

  Fly   581 GCYTNPGYTNCTGSLIGRT--MFKNEPTKNS--------GPVPIVGSTRAQAS---LPPVRKLFP 632
               |.|.|...|....|.:  |.|.....:|        ||...||.:...||   .|.|||.|.
  Fly   705 ---TAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFA 766

  Fly   633 ETWLFSNITDVGANGEYIIK--ETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTN 695
            |||:|:   |:.:..|.:.|  :|:|||:|:||:|||||.||.||.||.:.:.|:.|||||::..
  Fly   767 ETWIFA---DIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVR 828

  Fly   696 LPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPA 760
            |||||||||||.:|.:|||||...:..::.:||.|.:|:|::.:|:.:...    :|.:.:.:.|
  Fly   829 LPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQ----KRTQNIRVGA 889

  Fly   761 NTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLA 825
            |...|.||:||||.:|...||..|||..|||.:|:.|||..:|:.:|.|:|..||:     :...
  Fly   890 NEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINL-----KDTG 949

  Fly   826 PPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYL 890
            ..:.|..:|..::|:..||.|||.:.|....|.:::|::|:.||.|||||.|...||:.|...||
  Fly   950 EFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYL 1014

  Fly   891 KAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSA-----WGQHDAL--GSTWLTAYVIRSFH 948
            |:..:....::.:.||.::.|||..|:|:.:|||||:     |.|.|.:  |||||||||:|||.
  Fly  1015 KSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFS 1079

  Fly   949 QAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSHGSPLALTSFVLLTFFENEEYMPKY 1013
            :....||:|:.:|..|.:||::||:.:|.|.|.|...::|..|.|.||:..||...|.|:  |.
  Fly  1080 KIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEK--PN- 1141

  Fly  1014 KHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWTGS-DK 1077
            :..||:||.::.....:|.|....:||..||..|:...|.|.:..|..||....|..|||.. ||
  Fly  1142 QAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDK 1206

  Fly  1078 CKSS-------------EVETTSYVLLALL--EHNISDEPKPIVDWLISKRNSNGGFVSSQDTVV 1127
            .::|             :||.|||.||:||  :...:|.....|.|||::||..|||.|||||||
  Fly  1207 LRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVV 1271

  Fly  1128 GIMALTKYELQSHASTEAIDIEFWHLNEDKKH----VRVTKENEFKVQTHQLPENTNEVKLLAKG 1188
            |:.||.|:..:|  ..||...|....|:.|:.    :..::||:..:||.:.|:.|..::..|||
  Fly  1272 GLTALIKFAEKS--GYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKG 1334

  Fly  1189 QGRAQVQLTYRYNVATKEARPSFKLTTTV-KKSHKGRLILGICGTYTPIAASERNKTTNMALMQV 1252
            .|.|.||::|:||:..||.:||||:.||| .:|....|.|.:|..|.....|   |.:|||:::|
  Fly  1335 TGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGES---KESNMAILEV 1396

  Fly  1253 QLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPS 1317
            .|||||..|.:.||||..|..|:.|||||.|:.|.||||.|:..:.||:.:||..||||||.|||
  Fly  1397 SLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPS 1461

  Fly  1318 WVRLYDYYATERSATEFYHVDTSLCDICHGNECGNMC 1354
            .|.|||||.|.:.|||:|.:.:.|||||.|::|.:.|
  Fly  1462 SVVLYDYYDTNKKATEYYSIKSKLCDICEGDDCKSKC 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	35/87 (40%)
		A2M_N_2	411..542	CDD:285005	46/149 (31%)
		A2M	634..726	CDD:278630	47/93 (51%)
		A2M_2	859..1135	CDD:239227	118/298 (40%)
		A2M_comp	910..1135	CDD:284982	100/247 (40%)
		A2M_recep	1245..1335	CDD:284981	51/89 (57%)
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	36/92 (39%)
		A2M_N_2	528..653	CDD:285005	44/124 (35%)
		A2M	768..859	CDD:278630	47/93 (51%)
		A2M_2	982..1279	CDD:239227	118/299 (39%)
		A2M_comp	1035..1281	CDD:284982	101/248 (41%)
		A2M_recep	1389..1479	CDD:284981	51/89 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469026
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10215at33392
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	P	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
	11	10.800