DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep1 and c3a.1

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:NP_571317.1 Gene:c3a.1 / 321046 ZFINID:ZDB-GENE-990415-35 Length:1643 Species:Danio rerio


Alignment Length:1628 Identity:380/1628 - (23%)
Similarity:648/1628 - (39%) Gaps:421/1628 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTT-EVSVSLTG-PSLNSR-- 64
            |.||:.:|...||:..:.||.:.||..||..|:.||.|...:.::.. ||.:::.. |..:.:  
Zfish     5 LFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQDYSKNAFEVKITVKNHPKKDKQIL 69

  Fly    65 -KYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPD------------LNWL 116
             |.|::.:.::..:..|| |:.:   :..:.....:|.|.....:..||            ..::
Zfish    70 TKSVNLNAQNNFQILTDI-KIPD---DQNLFSDDPLEKQYVYLQAIFPDHTLEKVVLLSFQSGYI 130

  Fly   117 YIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQ 181
            ::|:||..|.|...:|:|.|.|..|.:| :....|.:||.: .||:..|...:.|.||:.||:..
Zfish   131 FVQTDKPIYTPSSTVQYRTLSLTPNLKP-LSQTGITVEIMN-PQNITVSSDKVYPVKGMKSGKYA 193

  Fly   182 LSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLTAK---NVAASAGYIRATIKAR 241
            :.:...||.|.|.....:  :...|....|.:||:|.|||.:..:|   .|...:  :...|:|:
Zfish   194 IPEVASLGIWKVVTRFANTPQKTFTAEFEVKEYVLPTFEVKLQPSKLFYYVGDES--LTVDIEAK 256

  Fly   242 YTFKKPVKGHVVAT-----------IEGSSTE-QSLPIDGEVNVEFPISATAKRLLKI------- 287
            |.|.|.|:|:....           |.||..: |.|...|...:...:..|.|.:.|:       
Zfish   257 YLFGKQVEGNAFVMFGVMDGETKTGITGSLQKIQILKGVGTAELTKQMIETYKSIDKLVGQSIYV 321

  Fly   288 -TAIVTE---ELTDIKHNGTAYVT-VHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDS 347
             .:::||   |:.:.:..|...|| .:....|....|    ::||:..:....|.|.|.:|..:.
Zfish   322 SVSLLTESGSEMVEAERRGIRIVTSPYTINFKKTAQF----FKPGMPFDVSIYVTNPDETPAQNV 382

  Fly   348 SKMVNFNVLCCQVSKN----FSASLQNSIATEHIMLPETCQSCLVTSTFDTAENIERYIYKL--- 405
            ...||...:..|...|    .:.:.|.::.|:.|    |.|    |...|..:. |:.:.|:   
Zfish   383 IVEVNPGGVRGQTKANGIAKVTVNTQGNVLTQEI----TAQ----TKDPDITDE-EQAVKKMTAH 438

  Fly   406 --------NKPLMIAINTKKPQLRKLLKINI-------ISDTYLPYFILTVVARGNIV-LSLFQE 454
                    ...|.|.|:..:.::...:|:|:       :.|....:.||   ::|.|| :..|  
Zfish   439 AYVPKGGSKNYLHIGIDAAELEIGDQMKVNLNTGQSPGVKDQDYTFMIL---SKGQIVKIDRF-- 498

  Fly   455 MKEKKKSQEI---------EFEPTFALVPQATIFVHYIIDGV--LMSDEKTVDIERDFENTIEIL 508
               |::.|.:         |..|:|.       ||.|...|.  ::||...||::......:::.
Zfish   499 ---KRQGQALITLSQPVTKEMVPSFR-------FVAYYHVGANEVVSDSVWVDVKDTCMGKLKLQ 553

  Fly   509 TTNEA---LPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYST------- 563
            ..|:.   ...:||.|::..:|.:.|||:.||::|.:|.. |.|.:..|.:.:..:.|       
Zfish   554 VKNKQNNYNTGEEVKLQISGDPGARVGLVVVDKAVHVLNK-NRLTQTKIWDVIEKHDTGCTAGGG 617

  Fly   564 --------DLVILTNANINIYRSSGGCYT--NP-------------------------------- 586
                    |..::..:|     ::||..|  ||                                
Zfish   618 RDVMGVFSDAGLMFESN-----TAGGTDTRLNPECPDPPKRRRRRTESENLRTITATLAGQYADG 677

  Fly   587 --------------GYT-------------------NCTGSLIGRTMFKNEPTK----------- 607
                          |||                   :|...:..|...|.|..:           
Zfish   678 QRQCCIDGMKDNKLGYTCERRATYIGDGPECVKAFLHCCDEMKKRKNIKTEEEEMILARSDDDDD 742

  Fly   608 -NSGPVPIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKET---VPDTLTSWVITGFS 668
             .:....||..|:           |||:||:..| |:..|......|.   :.|::|:|.:...|
Zfish   743 YYTDSEEIVSRTQ-----------FPESWLWEEI-DLCDNCPASAMEKAMYLKDSITTWQVLAVS 795

  Fly   669 LSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQY 733
            :||..|:.|. .|..|.||:..||...:|||..|||.:.|..|:.||.....|.:|         
Zfish   796 MSPTLGICVA-EPEEIVVFKSLFIDLKMPYSAVRGEQLEIKAIIHNYTPDKRKVRV--------- 850

  Fly   734 EFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILK 798
            ||:|:.:.......:| :.:.|:.||..:...:.::|.|..:|...:::.|.:..|         
Zfish   851 EFMESADVCSLASKKG-KYRTTVTIPKESSLSVPYVIIPMTLGNHMIEVKAAAYDA--------- 905

  Fly   799 VEADGVQ---KYVNKAVLINVQRLNRRSLAP---PEKTIIIE---KADNV----------IEG-- 842
            |..|||:   |.|::.||..:||.| ..|.|   .:..||:.   .||.|          |.|  
Zfish   906 VYTDGVRKGLKVVSEGVLFPLQRPN-VELNPVKNGDSPIIVRADIPADRVPGTPAHTHISITGEE 969

  Fly   843 -SETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKN--------RQDQ 898
             |:|||..:.|:       .:..|:..|.|||||||......::|..||.:.|        |:|:
Zfish   970 ISQTVEQAISGS-------FMGQLIVQPHGCGEQNMIFMTLPVIATHYLDSTNQWEAIGMKRRDE 1027

  Fly   899 EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVA 963
            .|     .:::|||..:..|::.|||::||  .|...||||||||.:.|..|...|.|::.||.:
Zfish  1028 AI-----GHIKTGYNRQQAYRKPDGSYAAW--IDRPSSTWLTAYVAKIFAMANDLITIEEQVLCS 1085

  Fly   964 GLDFLV-SRQSTDGKFKELGMVIH-------NSHGSPLALTSFVLLTFFENEEY-------MPKY 1013
            .|.:|| :||..||.|:|...|:|       ....:..:||:||.:...|..|.       :|: 
Zfish  1086 ALKWLVLNRQLPDGSFEEKAAVVHGEMVGDVQGRDAEASLTAFVTIAMQEGRELCGAIVGSLPE- 1149

  Fly  1014 KHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLD-----KLATRRGDHKWWT 1073
              .|.:||.|:..::::...||.:|:.:.|::.|         |||:     |.:|:.....:|.
Zfish  1150 --SIRKAVSFLEGKLNKLTNPYAVALTSYAMAGA---------DKLNKAVLMKFSTKGEAGTYWN 1203

  Fly  1074 GSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQ 1138
            ...:...:. |.|||.:|||::....:.....|.||.|:..|.||..::|.|::...|:.:|..|
Zfish  1204 VPGQQYHTR-EATSYAVLALVKARDFNAAGEAVHWLGSQHYSYGGSGTTQATIMVFQAVAEYRTQ 1267

  Fly  1139 SHASTE-AIDIEF----------WHLNEDKKHV----RVTKENEFKVQTHQLPENTNEVKLLAKG 1188
            ...|.. .:::|.          :.:..|.:||    :|....:|.|              .|||
Zfish  1268 VKDSQNFNLEVELAVEGRSKPSRYTIKRDNRHVSRSDKVDINKDFNV--------------TAKG 1318

  Fly  1189 QGRAQVQ---LTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYTPIAASERNKTT----- 1245
            .|:|.:.   |.|...|..|.....|.|:..:.|..:.:          ...|.|..|.|     
Zfish  1319 TGKATLSVLTLYYARPVEKKSDCTLFDLSVKIDKDPETK----------HADAIETFKLTMDFFY 1373

  Fly  1246 -------NMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHIYFEKL----SPGDRK 1299
                   .|.::.:.:|:|:..:   :.|:|.:       |:.::.    |.||.    :..||.
Zfish  1374 KNPKSPATMTILDIGIPTGFTVE---YNDLEEL-------TRGKEK----YLEKFEMDKALSDRG 1424

  Fly  1300 CLTLE------------AIYTHAVAN---LKPSWVRLYDYYATERSATEFYHVDTS--LCDICHG 1347
            .|.|.            |...|.:.|   |:|:.|.:|:||:.....|:::|.:..  :..:|.|
Zfish  1425 SLILYLKMVSNKESERIAFRMHKMLNVGLLQPAAVTIYEYYSPNARCTKYFHPEREGVIYRLCKG 1489

  Fly  1348 NEC 1350
            :.|
Zfish  1490 DMC 1492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 26/86 (30%)
A2M_N_2 411..542 CDD:285005 35/152 (23%)
A2M 634..726 CDD:278630 32/94 (34%)
A2M_2 859..1135 CDD:239227 90/303 (30%)
A2M_comp 910..1135 CDD:284982 74/244 (30%)
A2M_recep 1245..1335 CDD:284981 24/120 (20%)
c3a.1NP_571317.1 A2M_N 129..223 CDD:280081 27/95 (28%)
A2M_N_2 452..588 CDD:285005 34/150 (23%)
ANATO 666..735 CDD:237984 7/68 (10%)
A2M 759..851 CDD:278630 32/102 (31%)
complement_C3_C4_C5 979..1264 CDD:239226 91/311 (29%)
A2M_comp 1034..1264 CDD:284982 74/244 (30%)
A2M_recep 1380..1475 CDD:284981 23/108 (21%)
NTR_complement_C3 1494..1641 CDD:239638
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584204
Domainoid 1 1.000 56 1.000 Domainoid score I10957
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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