Protein Alignment Tep1 and c3a.2

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_571318.1
• Gene: c3a.2 / 30491
• ZFINID: ZDB-GENE-990415-36
• Length: 1651
• Species: Danio rerio
• Alignment Length: 1622
• Identity: 396/1622 - (24%)
• Similarity: 667/1622 - (41%)
• Gaps: 402/1622 - (24%)

  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVV--------------AIHN----TTRTT 50
            |.||:.:|...||:..:.||.::||..||..|:.||.|              ::.|    .....
Zfish     6 LFLSAVLLSSALLTLCDPLYVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKNVEMM 70

  Fly    51 EVSVSLTGPSLNSRKY---VDVQSMSSKSVRFD------------IPKLTEGDYELKVMGSGGIE 100
            :.:|:|||     .||   .|::....|:...|            .|.:|   .|..||    :.
Zfish    71 QKTVTLTG-----EKYQILTDIEIPDDKNFFSDDEKKQYVYLQAHFPSVT---LEKVVM----VS 123

  Fly   101 FQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKP-IKIEIRDGDQNLIK 164
            ||:          .:|::|:||..|.||..:|:|:..:..|.:|  :.:| |.::|.: .|.:..
Zfish   124 FQS----------GYLFVQTDKPIYTPGSNVQYRIFSMTPNLKP--LSQPGITVDIMN-PQGITV 175

  Fly   165 SWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNV--------LVVDKYVVPKFEVVV 221
            :...||..|||.|....:.|...||.|.|..      :.||.        ..|.:||:|.|| |.
Zfish   176 ASDAIKAEKGVKSSIYNIPDVTSLGMWKVVT------RYTNTPLKTFTAEFEVKEYVLPTFE-VK 233

  Fly   222 LTAKNVAASAG----------YIRATIKARYTFKKPVKGH---VVATIEGS------STEQSLPI 267
            ||..:.....|          .:...|:|:|.|.|.:.|:   |...::|:      ::.|.:|:
Zfish   234 LTPSSFFYYVGDNKQENDEEDSLTVDIEAKYLFGKKMDGNAFVVFGVMDGAAKTSIVNSLQKVPV 298

  Fly   268 -----DGEVNVEFPISATAKRLLKITA--------IVTE---ELTDIKHNG----TAYVTVHQHR 312
                 ..|:..|. |:.|.|.:..:..        ::||   |:.:.:..|    |:..|:|..|
Zfish   299 VNGVGTAELTREM-ITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKR 362

  Fly   313 HKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHI 377
            ..       ..::||:.......|.|.|.:|..|    |...||..........:..|.||...:
Zfish   363 TS-------QFFKPGMPLGVSVYVTNPDETPAKD----VEVEVLVDGKGGVSGKTRDNGIAKVKV 416

  Fly   378 MLPETCQSCLVTS--------------------TFDTAENIERYIYKLNKPLMIAINTKKPQLRK 422
            ..|....:..:|:                    .:.|..:.:.|::       |.|.:.:.::..
Zfish   417 NTPGGASTLKITAKTKNTEYTSEQQAVKTMTAQAYKTKHDSKNYLH-------INIESAEFEIGD 474

  Fly   423 LLKINIIS-------DTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI---------EFEPTFA 471
            .:.:|:|:       |....|.||   ::|.|||:    .:.|::.|.:         |..|:|.
Zfish   475 QMTVNLITGQSSGDRDQDYTYMIL---SKGQIVLA----ERFKRQGQTLVTLSLTITKEMVPSFR 532

  Fly   472 LVPQATIFVHYIIDGVLMSDEKTVDIE-----------RDFENTIEILTTNEALPRDEVSLKVKT 525
            .|    .:.|...|.| :||...||::           ::.:||.|  |.|      :|:|.:..
Zfish   533 FV----AYYHVGKDEV-VSDSVWVDVKDTCMGKLNVEVKEKKNTYE--TGN------DVNLHITG 584

  Fly   526 NPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYST---------DLVILTNANINIYRS--S 579
            :|.:.|||:.||::|.:|.. |.|.:..:.:.:..:.|         .:.:.::|.: |:.|  :
Zfish   585 DPGARVGLVVVDKAVQVLNK-NRLTQSKVWDVIEKHDTGCTGGGGKDSMGVFSDAGL-IFESNTA 647

  Fly   580 GG----------------------------------------CY-----TNPGYT---------- 589
            ||                                        ||     ...|||
Zfish   648 GGTDTRTVPECPAPLKRKRRSESLQTITTTLAGQYTEKIRPCCYDGMRNNRIGYTCERRASYVID 712

  Fly   590 --NCTGSLIGRTM-FKNEPTKNSGPVPIV---------GSTRAQASLPPVRKLFPETWLFSNITD 642
              .|..:.:.... .||...|.:....::         |..:....:.. |..|||:||:... |
Zfish   713 GEECVKAFLHCCKEVKNHKEKETEEEELILARSDEDEEGDYKDYDDITS-RTQFPESWLWEEF-D 775

  Fly   643 VGANGEYIIKETV---PDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGE 704
            :........|:.|   .|::|:|.|...||||..|:.|. .|..|.||:.|||...:|||..|||
Zfish   776 LCDKCSKPSKDKVIYLKDSITTWQILAISLSPTHGICVA-EPEEIVVFKSFFIDLKVPYSAVRGE 839

  Fly   705 VIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFM 769
            .:.|..|:.||....:| ||       :.||:||.....:...:| :.:.|:.:..::...:||:
Zfish   840 QVEIKAIIHNYTPKHLK-KV-------RVEFLETAGVCSAASKKG-KYRTTVNVDKDSSVAVSFV 895

  Fly   770 IRPKKVGLTTLKITA-ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAP---PEKT 830
            |.|..:....:::.| ||.|. |.:.:.|||.::||         :...|..:..|.|   .||.
Zfish   896 IVPMTLESQHIEVKASISDYE-DGVRKTLKVVSEGV---------LTKFRTEKLELNPGKKGEKP 950

  Fly   831 IIIEK---ADNV----IEGSETVEFEVCGTS--QAPQLEHLDDLVHLPCGCGEQNMFNFVPSILA 886
            :::..   ||.|    :....||..|....|  ||.....:.:|:..|.|||||||.......:|
Zfish   951 LVLRSGIPADQVPGTPVNSYITVTGEEISQSIEQAINGSFMGELIIQPHGCGEQNMVTMTLPFIA 1015

  Fly   887 LSYLKAKNRQDQ---EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFH 948
            ..||...|:.:.   :....|..:::|||:.:|.:::.|||::.|.:.|:  ||||||||.:.|.
Zfish  1016 THYLDNTNQWEYVGIDRRKVAINHIKTGYEGQLKFRKQDGSYALWIETDS--STWLTAYVAKVFA 1078

  Fly   949 QAAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIH-------NSHGSPLALTSFVLLTFFE 1005
            .|:|.|.|::||:.:.|.:|| .:|..||.|||...|.|       ....:.::||:|||:...|
Zfish  1079 MASKLIAIEENVICSALKWLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDVSLTAFVLIAMQE 1143

  Fly  1006 NEEY----MPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDK--LDKLAT 1064
            .:|.    :......|.::|.|:..::.:...||..|:.:.||:.|.:      |||  |.|.:|
Zfish  1144 GKEICGGAVGSLHESIRKSVAFLKNQLTKLTNPYAAALTSYALANADS------LDKEILMKHST 1202

  Fly  1065 RRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGI 1129
            :..|.::|........| :|.|:|.:|||::....|.....|.||..:::|:||:.::|.|::..
Zfish  1203 KGNDGRFWNVPGWHYHS-IEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVF 1266

  Fly  1130 MALTKYELQSHASTEAIDIEFWHLNED---------------KKHVRVTKENEFKVQTHQLPENT 1179
            .|:.:|..|..      |::.:.||.:               :.:|.:|:....        :..
Zfish  1267 QAVAEYRAQVQ------DLKNFDLNVELVVPGRRKTDRWTIQRSNVHLTRSGSV--------DMN 1317

  Fly  1180 NEVKLLAKGQGRAQVQ-LTYRYNVATKEARPSFKLT------TTVKKSHKGRLILGICGTYTPIA 1237
            .:..::|||.|.|.:. ||..|      |||..|.|      .:||.........|..|||..|.
Zfish  1318 KDFTVIAKGTGSAILSVLTLYY------ARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTYNFIL 1376

  Fly  1238 -ASERNKTTN--MALMQVQLPSGYVCDIEPFADIEAISDVK-RVETKNEDTEV-------HIYFE 1291
             ...:|||.:  |.::.:.||:|:  ||:. ||::.:|..| |...|.|..:|       .||..
Zfish  1377 DFFYKNKTNDATMTILDIGLPTGF--DIDE-ADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLN 1438

  Fly  1292 KLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYH---VDTSLCDICHGNEC 1350
            |:|..:.:.|......|..|..|:|:.|.:|:||:.:....::||   .|::|..:|.|:.|
Zfish  1439 KVSHKESETLVFRMHKTFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLC 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	26/85 (31%)
		A2M_N_2	411..542	CDD:285005	39/157 (25%)
		A2M	634..726	CDD:278630	35/94 (37%)
		A2M_2	859..1135	CDD:239227	90/292 (31%)
		A2M_comp	910..1135	CDD:284982	76/238 (32%)
		A2M_recep	1245..1335	CDD:284981	27/99 (27%)
c3a.2	NP_571318.1	A2M_N	128..222	CDD:280081	28/102 (27%)
		EMA	388..>469	CDD:280624	13/91 (14%)
		A2M_N_2	463..599	CDD:285005	38/155 (25%)
		ANATO	674..729	CDD:237984	6/54 (11%)
		A2M	768..861	CDD:278630	35/102 (34%)
		complement_C3_C4_C5	987..1272	CDD:239226	90/293 (31%)
		A2M_comp	1042..1272	CDD:284982	76/238 (32%)
		A2M_recep	1387..1482	CDD:284981	27/97 (28%)
		NTR_complement_C3	1502..1649	CDD:239638

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584180
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800