Protein Alignment Tep1 and Mug5

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_038963365.1
• Gene: Mug5 / 297568
• RGDID: 1584999
• Length: 1484
• Species: Rattus norvegicus
• Alignment Length: 1518
• Identity: 385/1518 - (25%)
• Similarity: 655/1518 - (43%)
• Gaps: 273/1518 - (17%)

  Fly    16 LSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD---VQSMSSKSV 77
            |.|.|..|.||.|..|.:.:...:.:.:::...|..|:.||.. ...:||..|   |.......|
  Rat    24 LLNGNSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLIS-QRGTRKLFDELVVDKDLFHCV 87

  Fly    78 RFDIPKLTEGDYE----LKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFL 138
            .|.||:|...:.|    :.:.|:.. :|.....:......:.:::|:||..||||..::|||:.:
  Rat    88 SFTIPRLPSSEEEESLDINIEGAKH-KFSERRVVLVKNKESVVFVQTDKPMYKPGQSVKFRVVSM 151

  Fly   139 DKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKV 203
            |||..|.....|:.. |.|...|.|..|:|:|...|:......||..|:.|.:.:....|...|.
  Rat   152 DKNLHPLNELFPLAY-IEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKE 215

  Fly   204 TNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHV-VATIEGSST------ 261
            .:...|.::|:|:|.|.|.....::.....|..|..|.||:.|||.||| ::...|:.|
  Rat   216 EHSFTVMEFVLPRFGVDVKVPNAISVYDEIINVTACATYTYGKPVPGHVKISLCHGNPTFSSETK 280

  Fly   262 ----EQSLPIDG------EVNV-EFPISATAKRL---LKITAIVTEELTDIKHNGTAYVTVHQHR 312
                |:...:|.      |||: ||.:.....::   ..:.|.||||.|..:.:|:..:.|.:.|
  Rat   281 SACKEEDSRLDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFSGSGRIEVERTR 345

  Fly   313 HKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHI 377
            :|...|...:|:|.|:....|..:.::.|.|:.:...::          |...|...|:..|:
  Rat   346 NKFLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVLI----------KARDAGYTNATTTD-- 398

  Fly   378 MLPETCQSCLVTSTFDTAE------NIERY--------------------------IYKLNKPLM 410
                  |..|...:.||:.      ||:.|                          :|.|:|. .
  Rat   399 ------QHGLAKFSIDTSGISDYSLNIKVYHKEESSCIHSSCTAERHAEAHHTAYAVYSLSKS-Y 456

  Fly   411 IAINTK----------KPQLRKLLKINIISDTYLPYFILTVVARGNIV-LSLFQEMKEKKKSQ-- 462
            |.::|:          ..|...:||..::.......|...|:|:|:|: ........|..:||
  Rat   457 IYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLQQIVFHYLVMAQGSILQTGNHTHQVEPGESQVQ 521

  Fly   463 ---EIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLK 522
               .:|....|::||.|.:.::.|: ||.:::|.....:|:...|.::: .:.:::||..:..::
  Rat   522 GNFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVKFQVEKCLRNKVQLSFSPSQSLPASQTHMR 586

  Fly   523 VKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLIL-------NNLATYSTD---------------- 564
            |..:|.|..||..|||||||.:...:|:..||.       :|....|.|
  Rat   587 VTASPQSLCGLRAVDQSVLLQKPEAELSPSLIYDLPGMQDSNFIASSNDPFEDEDYCLMYQPIAR 651

  Fly   565 ------------LVILTNANINIYRSSGGCYTNPGYTNCTGSLI-------------GRTMFKNE 604
                        |:..||..|.:          |.|.|....::             .|.|:::
  Rat   652 EKDVYRYVRETGLMAFTNLKIKL----------PTYCNTDYDMVPLAVPAVALDSSTDRGMYES- 705

  Fly   605 PTKNSGPVPIVGSTRAQASLPP-------------VRKLFPETWLFSNITDVGANGEYIIKETVP 656
                   :|:|.........||             :|..|||||::..:| |.::|...::.|||
  Rat   706 -------LPVVAVKSPLPQEPPRKDPPPKDPVIETIRNYFPETWIWDLVT-VNSSGVTELEMTVP 762

  Fly   657 DTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVK 721
            ||:|.|......||..:||.:: :.:..:.|||||:...:||||.|||...:...|.|||...:.
  Rat   763 DTITEWKAGALCLSNDTGLGLS-SVASFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTSLP 826

  Fly   722 AKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAIS 786
            ..||::.|. .:..:...| |...|..|          ||.....|:::.||.:|.....::|.:
  Rat   827 MAVLLEASP-DFTAVPVEN-NQDSYCLG----------ANGRHTSSWLVTPKSLGNVNFSVSAEA 879

  Fly   787 KYA----------------GDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEK 835
            :.:                .|.:.::|.||.:|::|....:.|:..      |.|...:|:.:..
  Rat   880 RQSPGPCGSEVATVPETGRKDTVVKVLIVEPEGIKKEHTFSSLLCA------SDAELSETLSLLL 938

  Fly   836 ADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEI 900
            ...|::.|....|.|.|...:..:::..:|:.:|.|||||||..|.|:|..|.||....:..::|
  Rat   939 PPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTEKI 1003

  Fly   901 ENKAKRYVETGYQIELNYKRNDGSFSAWGQHD--ALGSTWLTAYVIRSFHQAAKYIDIDKNVLVA 963
            ::||..|:..|||.|||||..|||:||:|.|:  ..|:|||||:|::||.||..:|.||::.:..
  Rat  1004 KSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITD 1068

  Fly   964 GLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFV 1024
            ...:|..:|...|.|:..|.:::|:.    ...:.|::::.:...|:.  :|....|:.:|:..:
  Rat  1069 AFTWLSKQQKDSGCFRSSGSLLNNAMKGGVDDEITLSAYITMALLESS--LPDTDPVVSKALSCL 1131

  Fly  1025 VT---EVHQSNE---PYDLAIAALALSLARN---RNAYKVLDKLDKLATRRGDHKWWTGSDK--- 1077
            .:   .:.|...   .|..|:.|.|.:||.|   ||  ::|..|||.|.:..:...|....|
  Rat  1132 ESSWENIEQGGNGSFVYTKALMAYAFALAGNQEKRN--EILKSLDKEAIKEDNSIHWERPQKPTK 1194

  Fly  1078 ---------CKSSEVETTSYVLLALLEHNISDEPKPI------VDWLISKRNSNGGFVSSQDTVV 1127
                     ..|:|||.::||:||.|....:..|:.:      :.||..::||.|||.|:|||||
  Rat  1195 SEGYLYTPQASSAEVEMSAYVVLARLTAQPAPSPEDLALSMGTIKWLTKQQNSYGGFSSTQDTVV 1259

  Fly  1128 GIMALTKY---ELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQ 1189
            .:.||:||   .......|.::.::  ......:..:|.|.|...:|...||.......:...|:
  Rat  1260 ALDALSKYGAATFSKSQKTPSVTVQ--SSGSFSQKFQVDKSNRLLLQQVSLPYIPGNYTVSVSGE 1322

  Fly  1190 GRAQVQLTYRYNVATKEARPSFKL-TTTVK---KSHKGRLILGICGTYTPIAASERNKTTNMALM 1250
            |....|.|.||||..::.:|:|.| ..||.   .:.||:....|.   ..|:.:.....:||.:.
  Rat  1323 GCVYAQTTLRYNVPLEKQQPAFALKVQTVPLTCNNPKGQNSFQIS---LEISYTGSRPASNMVIA 1384

  Fly  1251 QVQLPSGYVCDIEP-FADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTH--AVA 1312
            .|::.||:: .::| ...:|.:..|.|.|....:  |.:|.::::   .:.|:...|...  .|.
  Rat  1385 DVKMLSGFI-PLKPTVKKLERLGHVSRTEVTTNN--VLLYLDQVT---NQTLSFSFIIQQDIPVK 1443

  Fly  1313 NLKPSWVRLYDYYATERSATEFY 1335
            ||:|:.|::||||.|:..|...|
  Rat  1444 NLQPAIVKVYDYYETDEVAFAEY 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	322/1266 (25%)
		A2M_2	859..1135	CDD:239227	101/308 (33%)
		A2M_recep	1243..1336	CDD:462226	26/96 (27%)
Mug5	XP_038963365.1	YfaS	<129..1349	CDD:441940	329/1283 (26%)
		A2M_2	961..1267	CDD:239227	101/309 (33%)
		A2M_recep	1377..1467	CDD:462226	26/96 (27%)