DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and C3

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_058690.2	Gene:	C3 / 24232	RGDID:	2232	Length:	1663	Species:	Rattus norvegicus

Alignment Length:	1604	Identity:	400/1604 - (24%)
Similarity:	652/1604 - (40%)	Gaps:	357/1604 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLWLILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVS---------- 55
            :|.|:|:|:     ||:..:.:||::.|..||..|....::..|:......|:|:
  Rat    11 VLLLLLASS-----LLALGSPMYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVL 70

  Fly    56 ------LTGPS--LNSRKYVDVQSMSSKSVRFDIPKLTEG-DYELKVMGSGGIEFQNSTKLSFAP 111
                  |||.:  ||.   |.::..:||....|     :| .|...|...|....:.:..:||
  Rat    71 TSEKTVLTGATGHLNR---VSIKIPASKEFNAD-----KGHKYVTVVANFGATVVEKAVLVSF-- 125

  Fly   112 DLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVY 176
            ...:|:||:||..|.||..:.:|:..:|.|..|  :.|.:.|.|...|...||  :||..:...|
  Rat   126 QSGYLFIQTDKTIYTPGSTVFYRIFTVDNNLLP--VGKTVVIVIETPDGVPIK--RDILSSHNQY 186

  Fly   177 SGELQLS-DRPVL---GNWTVTATVQDEGKVT--NVLVVDKYVVPKFEVVVLTAKN---VAASAG 232
             |.|.|| :.|.|   |.|.:.|..:...|.|  ....|.:||:|.|||:|...:.   :....|
  Rat   187 -GILPLSWNIPELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKG 250

  Fly   233 YIRATIKARYTFKKPVKGHVV--------------------ATIEGSSTEQSLP----IDGEVNV 273
             :..:|.||:.:.|.|.|...                    ..||..|.|..|.    :|| |..
  Rat   251 -LEVSITARFLYGKNVDGTAFVIFGVQDEDKKISLAQSLTRVLIEDGSGEAVLSRKVLMDG-VRP 313

  Fly   274 EFPISATAKRL-LKITAIV--TEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTV 335
            ..|.:...|.| :.:|.|:  ..::.:.:.:|...||.....|..:.   |..::|.:..:....
  Rat   314 SSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKT---PKFFKPAMPFDLMVF 375

  Fly   336 VRNLDGSPVM-----------------DSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETC 383
            |.|.||||..                 |....::.|      :.|....|..::.|:...:|:..
  Rat   376 VTNPDGSPARRVPVVTQGSDAQALTQDDGVAKLSVN------TPNNRQPLTITVRTKKEGIPDAR 434

  Fly   384 QS--CLVTSTFDTAENIERYIYKLNKPLMIAINTKKP----QLRKLLKINIISDTYLPYFILTVV 442
            |:  .:....:.|..|...|::     |.::....||    .:...|:.:...:..:.|:...|:
  Rat   435 QATRTMQAQPYSTMHNSNNYLH-----LSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVM 494

  Fly   443 ARGNIVLSLFQEMKEKKKSQEI-------EFEPTFALVPQATIFVHYIIDGV-----LMSDEKTV 495
            .:|.: |...::::|..:...:       ||.|:|.||      .:|.:.|.     :::|...|
  Rat   495 NKGKL-LKAGRQVREPGQDLVVLSLPITPEFIPSFRLV------AYYTLIGANGQREVVADSVWV 552

  Fly   496 DIERDFENTIEILTTNEALPRD--------EVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRD 552
            |::.....|:.:    :..|||        :.:|:::.|..:.|||:.||:.|.:|...|.|.:.
  Rat   553 DVKDSCVGTLVV----KGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQS 613

  Fly   553 LILN---------------NLATYSTD--LVILTNANINIYR----------------------- 577
            .|.:               |.|....|  |...||..:...:
  Rat   614 KIWDVVEKADIGCTPGSGKNYAGVFMDAGLTFKTNQGLQTDQREDPECAKPAARRRRSVQLMERR 678

  Fly   578 -SSGGCYTNPGYTNC----------------TGSLI--GRTMFK------NEPTK---NSGPVPI 614
             ...|.||:.|...|                ...||  |.:..|      |..||   ......:
  Rat   679 MDKAGQYTDKGLRKCCEDGMRDIPMKYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRRDHV 743

  Fly   615 VGSTRAQAS---LPP----VRKLFPETWLFS--NITDVGANG--EYIIKETVPDTLTSWVITGFS 668
            :|..|:...   :|.    .|..|||:||::  .:.:...||  ..::...:.|::|:|.|...|
  Rat   744 LGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVS 808

  Fly   669 LSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMD-VKAKV-LMDNSDG 731
            ||.:.|:.|. :|..|.|.|.|||...|||||.|.|.:.|..::|||...: :|.:| |:.|.
  Rat   809 LSDKKGICVA-DPYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQEKLKVRVELLHNP-- 870

  Fly   732 QYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITA--ISKYAGDRLH 794
            .:..:.|..|         |..:|:.||..:...:.::|.|.|:||..:::.|  .:.:..|.:.
  Rat   871 AFCSMATAKK---------RYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAVFNHFISDGVK 926

  Fly   795 QILKVEADGVQKYVNKAVLINVQRLNRRSLAPP---------EKTIIIEKADNVIEGSETVEFEV 850
            :||||..:|::  |||.|.:       |:|.|.         |.....:.:|.|.:........:
  Rat   927 KILKVVPEGMR--VNKTVAV-------RTLDPEHLGQGGVQREDVPAADLSDQVPDTDSETRILL 982

  Fly   851 CGTSQAPQLEHLDD---LVHL---PCGCGEQNMFNFVPSILALSYLKAKNRQDQ---EIENKAKR 906
            .||..|...|...|   |.||   |.|||||||....|:::|:.||....:.::   |...:|..
  Rat   983 QGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGLEKRQEALE 1047

  Fly   907 YVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLV-S 970
            .::.||..:|.:|:...:::|:.....  ||||||||::.|..||..|.||..||...:.:|: .
  Rat  1048 LIKKGYTQQLAFKQPSSAYAAFNNRPP--STWLTAYVVKVFSLAANLIAIDSQVLCGAVKWLILE 1110

  Fly   971 RQSTDGKFKELGMVIH--------NSHGSPLALTSFVLLTFFEN----EEYMPKYKHVIDRAVEF 1023
            :|..||.|:|.|.|||        |:..:.::||:|||:...|.    |..:......|::|.|:
  Rat  1111 KQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEY 1175

  Fly  1024 VVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDK------LATRRGDHKWWTGSDKCKSSE 1082
            :.........||.:|||..||:|         ::||::      |.|.:..::|.....:..:
  Rat  1176 LEASYLNLQRPYTVAIAGYALAL---------MNKLEEPYLTKFLNTAKDRNRWEEPGQQLYN-- 1229

  Fly  1083 VETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY------------ 1135
            ||.|||.|||||.....|...|:|.||..:|...||:.|:|.|.:...||.:|
  Rat  1230 VEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQTDVPDHKDLNM 1294

  Fly  1136 ELQSHASTEAIDIEFWHLNEDKKHVR--VTKENE-FKVQTHQLPENTNEVKLLAKGQGRAQVQLT 1197
            ::..|..:.:....|..|.|....:|  .||:|| |.:...            .||||...|...
  Rat  1295 DVSLHLPSRSSPTVFRLLWESGSLLRSEETKQNEGFSLTAK------------GKGQGTLSVVTV 1347

  Fly  1198 YRYNVATKEARPSFKLTTTVK---------KSHKGRLILGICGTYTPIAASERNKTTNMALMQVQ 1253
            |...|..|.....|.|..|:|         :..|..:||.||..|.      .:....|:::.:.
  Rat  1348 YHAKVKGKATCKKFDLRVTIKPAPETAKKPQDAKSSMILDICTRYL------GDVDATMSILDIS 1406

  Fly  1254 LPSGYVCDIEPFADIEAISD-VKRVETK--------NEDTEVHIYFEKLSPGDRKCLTLEAIYTH 1309
            :.:|::.|..   |:|.:|. |.|..:|        |::|.: ||.||:|..:..||:.:.....
  Rat  1407 MMTGFIPDTN---DLELLSSGVDRYISKYEMDKAFSNKNTLI-IYLEKISHSEEDCLSFKVHQFF 1467

  Fly  1310 AVANLKPSWVRLYDYYATERSATEFYHV---DTSLCDICHGNEC 1350
            .|..::|..|::|.||..|.|.|.|||.   |..|..:||...|
  Rat  1468 NVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHNEMC 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	30/88 (34%)
		A2M_N_2	411..542	CDD:285005	31/154 (20%)
		A2M	634..726	CDD:278630	33/97 (34%)
		A2M_2	859..1135	CDD:239227	97/303 (32%)
		A2M_comp	910..1135	CDD:284982	78/243 (32%)
		A2M_recep	1245..1335	CDD:284981	27/98 (28%)
C3	NP_058690.2	A2M_N	129..224	CDD:280081	32/99 (32%)
		A2M_N_2	457..603	CDD:285005	32/156 (21%)
		ANATO	678..747	CDD:237984	13/68 (19%)
		A2M	770..866	CDD:278630	33/96 (34%)
		complement_C3_C4_C5	996..1282	CDD:239226	96/298 (32%)
		A2M_comp	1051..1282	CDD:284982	78/243 (32%)
		A2M_recep	1398..1493	CDD:284981	27/98 (28%)
		NTR_complement_C3	1513..1661	CDD:239638
		Interaction with CFP/properdin. /evidence=ECO:0000250\|UniProtKB:P01024	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343886
Domainoid	1	1.000	50	1.000	Domainoid score	I11352
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840