DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and A2ml1

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001001179.2	Gene:	A2ml1 / 232400	MGIID:	3039594	Length:	1456	Species:	Mus musculus

Alignment Length:	1546	Identity:	386/1546 - (24%)
Similarity:	657/1546 - (42%)	Gaps:	309/1546 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD 68
            ::||:.:||...:..|...|.:.....::..|:....:.:.|...:..:||:|
Mouse     5 ILLSALLLHFTDVVAAEPRYILWVSSVVQRFSSEKACLHLLNLNESVSLSVTL------------ 57

  Fly    69 VQSMSSKSVRFDIPKLTEG------DYELKVMGSGGIEF------QNSTKLS------FAPDLNW 115
             :...|.:..||.| :.||      |:::..|.|..:.|      .|:.|:|      .|.:.|.
Mouse    58 -EYDGSSTTIFDQP-VDEGNFYACADFKVSQMSSEQLAFVALLVQGNTLKISERRSVAIAAEENA 120

  Fly   116 LYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGEL 180
            .::|:|...:||||.:.|||:.|:...:| |.|....|.::|...|:|..|.::...:.:.....
Mouse   121 TFVQTDTPVHKPGDTVHFRVVTLNIWLKP-VDDLYPLITVQDPQSNVIFQWINVTTFRNITQLSF 184

  Fly   181 QLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFK 245
            ||:..|:||::|:....|....|.:...|::.|:|||||.:...:.:..:....:....|:||:.
Mouse   185 QLTPEPILGDYTIVIKTQSGTTVMDHFTVNRDVLPKFEVELTAPETITIADSQFQMVTCAKYTYG 249

  Fly   246 KPVKGHVVATI--EGSSTEQSLPIDGEVNVEFPI---SATAKRL----------------LKITA 289
            :||:|.....:  |..|.......:.|:..:|.:   ...|..:                |.:..
Mouse   250 QPVQGKAQIKVCRELFSPAHCESNENEICEQFTVQLKDGCASHIINTKVFQLDRSGLFMTLNVNE 314

  Fly   290 IVTEELTDIKHNGT--AYVTVHQHRHKLEDLFWPTHYRPGV----SSEF----------KTVVRN 338
            :|||..|.::.:.|  .::|........|::  ...||.|:    :.:|          |.:...
Mouse   315 VVTESGTGVQMSKTHSVFITSVLGTVSFENM--DPFYRRGITYFGTLKFSGPNNTPLVDKLLQLE 377

  Fly   339 LDGSPV----MDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETC--QSCLVTSTFDTAEN 397
            |||.||    .|.:....|::   ..|:.|.|  |.|:...::. |.:|  .|.|.....|...:
Mouse   378 LDGKPVGNYTTDENGEARFSI---NTSEIFGA--QISLKAVYVR-PRSCHRSSWLSPEYLDAYFS 436

  Fly   398 IERYIYKLNKPLMIAINTKKPQL----RKLLKI--NIISDTY-----LPYFILTVVARGNIVLSL 451
            ..|:..:.:....|.:..|  ||    .|:..:  ::..:.|     :.:|.| |:.||.|..|.
Mouse   437 ASRFYSQTSSFTKIILEPK--QLPCDQEKMFSVLYSLNPEAYKEASDVTFFYL-VMVRGGISRSG 498

  Fly   452 FQEMKEKKKSQEIEFEPTF--ALVPQATIFVHYI-IDGVLMSDEKTVDIERDFENTIEI-LTTNE 512
            .::::.:..:....|..:.  .|.|.|.:||:.: ..|.:::|...:.||:.|:|.:.| .:.::
Mouse   499 QKQVRVQAWNGNFSFPISINADLAPSADLFVYTLHPSGEIVADNVRLQIEKCFKNKVSINFSRDK 563

  Fly   513 ALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSG----------------------NDLN----- 550
            .||....|:.::..|.||..|..||:|.|||..|                      |.||
Mouse   564 DLPGSNTSVHLQAAPDSFCALRAVDKSALLLNHGQEMTPESVYFTLPYIHQYGYFYNGLNLDDQQ 628

  Fly   551 -------RDLILNNLATYST--------DLV-ILTNANINIYRSSGGCYTNPGYTN---CTGSLI 596
                   :||..|.|  |.|        ||. :|:|..:.|       :||..|..   |:..
Mouse   629 AEPCIPQKDLFYNGL--YYTPTGNIWDGDLSNLLSNMGLKI-------FTNLHYRKPEVCSSQ-- 682

  Fly   597 GRTMFKNEPTKNSGPVPIVGSTRAQASLPP---------------------VRKLFPETWLFSNI 640
                 :|:|...:...|...........||                     ||..||.||:: |:
Mouse   683 -----ENQPLLRTFDHPNERIMMYGGGAPPSSAFHDSVDSISHAKVAIKETVRTNFPRTWIW-NL 741

  Fly   641 TDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEV 705
            ..|.::|...:...||||:|.|..:.|.::..:|..::...| :::.||||:....|:||.|.|.
Mouse   742 VSVDSSGTANVSFLVPDTITQWEASAFCVNGNAGFGISPKVS-LQISQPFFVEVTSPFSVVRSEQ 805

  Fly   706 IAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMI 770
            ..:.|.|||||...|:..|.::.|:.....|.|.....|:.|:...:|..:|           .|
Mouse   806 SDMVVTVFNYLTTCVEISVQLEASENYEASINTQRNTDSEVLQAGEQKTYVW-----------TI 859

  Fly   771 RPKKVGLTTLKITAISKYA---------------GDRLHQILKVEADGVQKYVNKAVLINVQRLN 820
            .||.:|...:.:.|.||.:               .|.:.:.:.|||:|::|...::.||
Mouse   860 IPKTLGKVNVTVVATSKQSRACPNDASKEQDVHWKDTVVKTMLVEAEGIEKEATQSFLI------ 918

  Fly   821 RRSLAP----PEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFV 881
                .|    ..|..::|...||:|||......:.|......:::|:.|:.:|.||||||:....
Mouse   919 ----CPKGTKASKQTLLELPSNVVEGSVRSFVTIVGDILGVAMQNLESLLQMPYGCGEQNIAQLA 979

  Fly   882 PSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRS 946
            ..:..|.||||.::..:|:::||:|.:..|||..|::|..|||:..:.|.:..|||||:|...::
Mouse   980 SDVYILDYLKATDQLTEELKSKAQRLLSNGYQNHLSFKNYDGSYDVFCQSNQEGSTWLSALSFKT 1044

  Fly   947 FHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKF----KELGMVIHNSHG--SPLALTSFVLLTFFE 1005
            ..:..:||.|::.|....|.:||.:|.::|.|    |.:........|  ..:|||::|:..|.|
Mouse  1045 VEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRRDEKHVDTAQEGREGDQEDIALTAYVVGVFLE 1109

  Fly  1006 ---NEEYMPKYK---HVIDRAVEFVVTEVHQSNEPYDLAIAALALSLA-RNRNAYKVLDKLDKLA 1063
               |..: |..:   :.::.|....||      ..|..||.|...:|| :.:.|..:|..|||.|
Mouse  1110 VGLNASF-PALRNGLYCLEEAFSNGVT------NGYTQAILAYVFALAGKEQQAKSLLSILDKSA 1167

  Fly  1064 TRRGDHKWWTGSDK------------CKSSEVETTSYVLLALLEHNIS--DEPKPIVDWLISKRN 1114
            |:..:..:|...:|            ..|.|.|.|.|||||:|..:..  |....||.||..:.|
Mouse  1168 TKTNNMIYWERDEKPETDNSPSFIPSALSGETEKTCYVLLAVLSQDTQDLDYASKIVQWLAQRMN 1232

  Fly  1115 SNGGFVSSQDTVVGIMALTKY------------ELQSHASTEAIDIEFWHLNEDKK----HVRVT 1163
            |:|||.:.|||.|.::|||:|            .|.|..|.|.     :::|.:|:    |.:|:
Mouse  1233 SHGGFSAMQDTTVCLLALTQYMKLTGSNPQNTITLSSEESEEV-----FYVNRNKRLLVQHSKVS 1292

  Fly  1164 KENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKG----- 1223
            |       .||  :.|.:|    :|.|.:.:|.|.||||...:....|.|:....||:..
Mouse  1293 K-------GHQ--QYTVDV----EGDGCSFIQATLRYNVPLPKEASGFSLSVKTGKSNSSDEFQT 1344

  Fly  1224 RLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHI 1288
            :..|.:..|||  .|.|.:.|   .|:.|::.||:...:....:::..|.|.:.:.||  ..|..
Mouse  1345 KFELTVTLTYT--GARESSVT---VLVDVKMLSGFTPVVSSTEELKFNSQVTKTDIKN--GHVLF 1402

  Fly  1289 YFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDT 1339
            |.|.: |.:...||.....|:.|||::|:.|.:|.|...| .|.:.|::::
Mouse  1403 YLENV-PKEATSLTFSIEQTNHVANIQPAPVTVYSYEKGE-YAFDSYNINS 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	25/84 (30%)
		A2M_N_2	411..542	CDD:285005	36/145 (25%)
		A2M	634..726	CDD:278630	31/91 (34%)
		A2M_2	859..1135	CDD:239227	98/302 (32%)
		A2M_comp	910..1135	CDD:284982	80/251 (32%)
		A2M_recep	1245..1335	CDD:284981	24/89 (27%)
A2ml1	NP_001001179.2	A2M_N	121..204	CDD:280081	25/83 (30%)
		A2M_N_2	450..593	CDD:285005	36/145 (25%)
		A2M	736..826	CDD:278630	31/91 (34%)
		A2M_2	956..1253	CDD:239227	98/303 (32%)
		A2M_comp	1008..1253	CDD:284982	80/251 (32%)
		A2M_recep	1364..1447	CDD:284981	24/86 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840015
Domainoid	1	1.000	66	1.000	Domainoid score	I9869
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650