DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and A2m

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_783327.2	Gene:	A2m / 232345	MGIID:	2449119	Length:	1474	Species:	Mus musculus

Alignment Length:	1537	Identity:	400/1537 - (26%)
Similarity:	646/1537 - (42%)	Gaps:	282/1537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILHCVLLSNANG----LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD-- 68
            :|..:|.:||:.    :|.|:.|..|.:.:.....:..::...|..|.||:.....|...:.|
Mouse    21 LLLLLLPTNASAPQKPIYMVMVPSLLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLFTDLV 85

  Fly    69 ------------VQSMSSKSVRFDIPKLTEGDYELKVMGSGGI-EFQNSTKLSFAPDLNWLYIQS 120
                        |...||..|.|           |.|...|.. ||:..:.:......:.::.|:
Mouse    86 VDKDLFHCASFIVPQSSSNEVMF-----------LTVQVKGPTHEFRRRSTVLIKTKESLVFAQT 139

  Fly   121 DKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDR 185
            ||..||||..::|||:.||:|..|.....|: :.|:|..:|.|..|::.:...|:......||..
Mouse   140 DKPIYKPGQMVRFRVVSLDENFHPLNELIPL-LYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSE 203

  Fly   186 PVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKG 250
            |..|::.|....:....|.:...|.::|:|||||.|...:.:......:..::...||:.|||.|
Mouse   204 PTQGSYKVVIRTESGRTVEHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPG 268

  Fly   251 HVVATI-----EGSST--EQSL--------PIDGEVNVEFPISATAKRL--------LKITAIVT 292
            ||...|     ..||.  |:||        .:||.......:...:.:|        |.:.|.:.
Mouse   269 HVTVNICRKYSNPSSCFGEESLAFCEKFSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVNAKIQ 333

  Fly   293 EELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPV--------MDSSK 349
            ||.|.::..|.....:.:...||..:...||:|.|:....:.::.:..|:|:        .|.:.
Mouse   334 EEGTGVEETGKGLTKITRTITKLSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFIGADEAN 398

  Fly   350 MVNFNVLCCQVSKNFSASLQNSIATEHIMLPETCQSCLVTSTFD-----------TAENIERY-- 401
            . |.|.   ...||..|..  ||.|:.||    ..|..|.:.:.           |.||:|.:
Mouse   399 Q-NINT---TTDKNGLARF--SINTDDIM----GTSLTVRAKYKDSNVCYGFRWLTEENVEAWHT 453

  Fly   402 -----------------IYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNI-- 447
                             .|||.....:|:     |...:|....:.:.....|...::|:|.|
Mouse   454 ANAVFSPSRSFVHLESLPYKLRCEQTLAV-----QAHYILNDEAVLERKELVFYYLMMAKGGIVR 513

  Fly   448 ----VLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIE- 506
                ||.:.|..|:...|..|..|..  |.|.|.:.::.|: :|.::.|....:||:...|.::
Mouse   514 AGTHVLPVTQGHKKGHFSILISMETD--LAPVARLVLYTILPNGEVVGDTVKYEIEKCLANKVDL 576

  Fly   507 ILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTDLVILTNA 571
            :...|..||.....|.|..:|.|..||..|||||||.:...:|:..|:.:.|..  .||......
Mouse   577 VFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLLTKPEAELSASLVYDLLPV--KDLTGFPKG 639

  Fly   572 NINIYRSSGGCY-TNPGYTNCTGSLIGRTMFKNEP-----TKNSG-------------------- 610
            .......:.||. .|..|.|  |.|.......||.     .|:.|
Mouse   640 VNQQEEDTNGCLKQNDTYIN--GILYSPVQNTNEEDMYGFLKDMGLKVFTNLNIRKPKVCERLGV 702

  Fly   611 -PVP----IVGSTRAQASL-------PPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWV 663
             .:|    :|......|.|       ...|..|||||:: ::..|.:.|...::.|||||:|.|.
Mouse   703 NKIPAAYHLVSQGHMDAFLESSESPTETTRSYFPETWIW-DLVIVDSTGVAEMEVTVPDTITEWK 766

  Fly   664 ITGFSLSPQSGLAVTRNP-SRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMD 727
            ...|.||..:||.:  :| ...:.|||||:...:||||.|||...:...|.|||...::..|.::
Mouse   767 AGAFCLSNDTGLGL--SPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLE 829

  Fly   728 NSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDR 792
            .|.   :|:.|..:         :.:|:..|..|....:|:.:.||.:|.....::|.:..:.:.
Mouse   830 ASP---DFLATPEE---------KEQKSHCICMNERHTMSWAVIPKSLGNVNFTVSAEALDSKEL 882

  Fly   793 L-HQILKVEADGVQKYVNKAVLINVQRLNR----RSLAPP-----EKTIIIEKADNVIEGSETVE 847
            . :::..|...|.:..:.|::|:..:.|..    .||..|     .:.|.::...:|:|.|....
Mouse   883 CRNEVPVVPERGKKDTIIKSLLVEPEGLENEVTFNSLLCPTGAEVSEQISLKLPSDVVEESARAS 947

  Fly   848 FEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGY 912
            ..|.|......:::..||:.:|.|||||||..|.|:|..|.||....:..|||:.||..|:.|||
Mouse   948 VTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGY 1012

  Fly   913 QIELNYKRNDGSFSAWGQHDALG----STWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQS 973
            |.:||||..|||:|.:|  |..|    :|||||:|::||.||.:||.||::.:...|.:|..:|.
Mouse  1013 QRQLNYKHRDGSYSTFG--DKPGRSHANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQK 1075

  Fly   974 TDGKFKELGMVIHNSH----GSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQS--- 1031
            .:|.|:..|.:::|:.    ...:.|::::.:...|..  :| ..|.:.|...|.:....:|
Mouse  1076 DNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMS--LP-VTHPVVRNALFCLDTAWKSARR 1137

  Fly  1032 ----NEPYDLAIAALALSLARNRNAYK-VLDKLDKLATRRGDHKWWTGSDK------------CK 1079
                |..|..|:.|.|.:||.|::..| :|..||:.|.:..:...||.:.|            ..
Mouse  1138 GASGNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEDNSVHWTRAQKPRVPADLWYQPQAP 1202

  Fly  1080 SSEVETTSYVLLALLEHNISDEPKP----------IVDWLISKRNSNGGFVSSQDTVVGIMALTK 1134
            |:|||.|:|||||.|    :.|..|          ||.||..::||:|||.|:|||||.:.||:|
Mouse  1203 SAEVEMTAYVLLAYL----TTELVPTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSK 1263

  Fly  1135 Y--------ELQSHA---STEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKG 1188
            |        :..:|.   |:.|...:|          :|..:|:..:|...||....:......|
Mouse  1264 YGAATFTRAKKAAHVTIQSSGAFYTKF----------QVNNDNQLLLQRVTLPTVPGDYTAKVAG 1318

  Fly  1189 QGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGIC---GTYTPIAAS------ERNKT 1244
            :|...:|.:.:|:|..:|....|.|..        :.:.|.|   ..:|....|      .....
Mouse  1319 EGCVYLQTSLKYSVLPREKEFPFALVV--------QTLPGTCEDLKAHTTFQISLNISYIGSRSD 1375

  Fly  1245 TNMALMQVQLPSGYVCDIEPFAD-IEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYT 1308
            :|||:..|::.||:: .::|... :|....|.|.|..|  ..|.||.:|:|   .:.|||..:..
Mouse  1376 SNMAIADVKMVSGFI-PLKPTVKMLERSVHVSRTEVSN--NHVLIYLDKVS---NQMLTLFFMVQ 1434

  Fly  1309 H--AVANLKPSWVRLYDYYATERSATEFYHVDTSLCDICHGN 1348
            .  .|.:|||:.|::||||..:..|...|   ::.|...:||
Mouse  1435 QDIPVRDLKPAIVKVYDYYEKDEFAVAKY---SAPCSAGYGN 1473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	26/84 (31%)
		A2M_N_2	411..542	CDD:285005	37/138 (27%)
		A2M	634..726	CDD:278630	34/92 (37%)
		A2M_2	859..1135	CDD:239227	111/313 (35%)
		A2M_comp	910..1135	CDD:284982	89/262 (34%)
		A2M_recep	1245..1335	CDD:284981	30/92 (33%)
A2m	NP_783327.2	A2M_N	135..227	CDD:280081	27/92 (29%)
		A2M_N_2	473..612	CDD:285005	39/145 (27%)
		Bait region. /evidence=ECO:0000250\|UniProtKB:P01023	623..752		27/133 (20%)
		A2M	738..828	CDD:278630	34/92 (37%)
		A2M_2	958..1264	CDD:239227	111/314 (35%)
		A2M_comp	1010..1266	CDD:284982	91/264 (34%)
		A2M_recep	1376..1463	CDD:284981	30/92 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840019
Domainoid	1	1.000	227	1.000	Domainoid score	I2492
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650